J. Rehwinkel

Target-specific requirements for enhancers of decapping in miRNA-mediated gene silencing (2007)

Eulalio, Anna, Rehwinkel, J., Stricker, M., Huntzinger, Eric, Young, S.F., Doerks, T., ...

microRNAs (miRNAs) silence gene expression by suppressing protein production and/or by promoting mRNA decay. To elucidate how silencing is accomplished, we screened an RNA interference library for...

mRNA quality control: an ancient machinery recognizes and degrades mRNAs with nonsense codons. (2007)

Behm-Ansmant, Isabelle, Kashima, I., Rehwinkel, J., Sauliere, J., Wittkopp, Nadine, Izaurralde, Elisa

Nonsense-mediated mRNA decay (NMD) is an mRNA surveillance pathway which ensures the rapid degradation of mRNAs containing premature translation termination codons (PTCs or nonsense codons), thereby...

A conserved role for cytoplasmic poly(A)-binding protein 1 (PABPC1) in nonsense-mediated mRNA decay (2007)

Behm-Ansmant, Isabelle, Gatfield, D., Rehwinkel, J., Hilgers, V., Izaurralde, Elisa

The nonsense-mediated mRNA decay (NMD) pathway degrades mRNAs with premature translation termination codons (PTCs). The mechanisms by which PTCs and natural stop codons are discriminated remain...

miRNAs silence gene expression by repressing protein expression and/or by promoting mRNA decay. (2007)

Behm-Ansmant, Isabelle, Rehwinkel, J., Izaurralde, Elisa