Human chromosome 7: DNA sequence and biology (2003)
Scherer, S.W., Cheung, J., MacDonald, J.R., Osborne, L.R., Nakabayashi, K., ...
DNA sequence and annotation of the entire human chromosome 7, encompassing nearly 158 million nucleotides of DNA and 1917 gene structures, are presented. To generate a higher order description,...
Maffei, M, Fei, H, Lee, G H, Dani, C, Leroy, P, Zhang, Y, ...
The gene product of the recently cloned mouse obese gene (ob) is important in regulating adipose tissue mass. ob RNA is expressed specifically by mouse adipocytes in vivo in each of several different...
Smerdon, S J, Jäger, J, Wang, J, Kohlstaedt, L A, Chirino, A J, Friedman, J M, ...
The dipyridodiazepinone Nevirapine is a potent and highly specific inhibitor of the reverse transcriptase (RT) from human immunodeficiency virus type 1 (HIV-1). It is a member of an important class...
Wang, J, Smerdon, S J, Jäger, J, Kohlstaedt, L A, Rice, P A, Friedman, J M, ...
The reverse transcriptase from human immunodeficiency virus type 1 is a heterodimer consisting of one 66-kDa and one 51-kDa subunit. The p66 subunit contains both a polymerase and an RNase H domain;...
Truett, G E, Bahary, N, Friedman, J M, Leibel, R L
The autosomal recessive mutations fa (rat) and db (mouse) cause obesity syndromes that develop early and ultimately become severe. Although both fa/fa rats and db/db mice have been studied...
Molecular mapping of the mouse db mutation.
Bahary, N, Leibel, R L, Joseph, L, Friedman, J M
Diabetes (db) is an autosomal recessive mutation located in the midportion of mouse chromosome 4 that results in profound obesity with hyperphagia, increased metabolic efficiency, and insulin...
Medical genetics: 1. Clinical teratology in the age of genomics
Polifka, Janine E., Friedman, J.M.
Teratogenic exposures are those that can cause an embryo or fetus to develop abnormally. Several factors determine whether an agent is teratogenic, including the gestational timing of the exposure,...
Cocrystal structure of an editing complex of Klenow fragment with DNA.
Freemont, P S, Friedman, J M, Beese, L S, Sanderson, M R, Steitz, T A
High-resolution crystal structures of editing complexes of both duplex and single-stranded DNA bound to Escherichia coli DNA polymerase I large fragment (Klenow fragment) show four nucleotides of...
Vitale, M, Vashishtha, A, Linzer, E, Powell, D J, Friedman, J M
In this paper we describe experiments that address specific issues concerning the regulation of the mouse cholecystokinin gene in brain and intestine. The mouse cholecystokinin gene was cloned and...
We present evidence that differences in the levels of N-myc mRNA among different cell types are the result of posttranscriptional control. First, we noted that while steady-state mouse N-myc mRNA...
Friedman, J M, Babiss, L E, Clayton, D F, Darnell, J E
Recombinant adenoviruses were constructed in which the viral E1A gene was deleted and the E1B promoter was replaced by the rat albumin, mouse beta-major globin, or mouse immunoglobulin heavy-chain...
Babiss, L E, Friedman, J M, Darnell, J E
In the accompanying paper (Friedman et al., Mol. Cell. Biol. 6:3791-3797, 1986), hepatoma-specific expression of the rat albumin promoter within the adenovirus genome was demonstrated. However, the...
Babiss, L E, Bennett, A, Friedman, J M, Darnell, J E
As tested by DNase I digestion, the chromatin structure in several regions 5' to the rat serum albumin gene varies in tissues and cell lines that differ in transcription rate of this gene. Three...
Expression of the cholecystokinin gene in pediatric tumors.
Friedman, J M, Vitale, M, Maimon, J, Israel, M A, Horowitz, M E, Schneider, B S
We have examined a wide range of cultured human tumor cell lines and found that a specific subset of tumors expresses the cholecystokinin (CCK) gene. All neuroepitheliomas (eight) and Ewing sarcoma...
Protein-heme interaction in hemoglobin: evidence from Raman difference spectroscopy.
Shelnutt, J A, Rousseau, D L, Friedman, J M, Simon, S R
Raman difference spectroscopy measurements on native and chemically modified human deoxyhemoglobins stabilized in either the R or the T quaternary structure revealed frequency differences in the...
Friedman, J M, Rousseau, D L, Adar, F
Resonance Raman scattering excitation profile data have been obtained on ferrocytochromes c and b5 in the alpha absorption band region. We observe in cytochrome c that the shape of the excitation...
Friedman, J M, Babiss, L E, Weiss, M, Darnell, J E
A series of rat hepatoma cell lines was infected with a recombinant adenovirus bearing the rat albumin promoter. Transcription from this promoter was scored directly and was highest in FAO, the...
Baser, Michael E., Kuramoto, Lisa, Joe, Harry, Friedman, J. M., Wallace, Andrew J., Gillespie, James E., ...
Neurofibromatosis 2 (NF2) is an autosomal dominant disease that is characterized by tumors on the vestibular branch of the VIII cranial nerve, but other types of nervous system tumors usually occur...
Huang, J, Leone, M, Boffi, A, Friedman, J M, Chiancone, E
The near-infrared charge transfer band at 760 nm (band III) has been investigated in deoxy and photodissociated dimeric Scapharca hemoglobin. At 300 K, the 10-ns spectrum of the carbonmonoxy...
Mortality in Neurofibromatosis 1: An Analysis Using U.S. Death Certificates
Rasmussen, Sonja A., Yang, Quanhe, Friedman, J. M.
Although neurofibromatosis 1 (NF1) is a relatively common autosomal dominant condition, information about its effect on mortality is limited. We used Multiple-Cause Mortality Files, compiled from...
Carboxy Mb at pH 3. Time-resolved resonance Raman study at cryogenic temperatures.
Iben, I E, Cowen, B R, Sanches, R, Friedman, J M
Cryogenic samples of MbCO at pH3 are studied using nanosecond and picosecond time-resolved resonance Raman spectroscopy. It is observed that under excitation conditions sufficient to completely...
Iben, I E, Stavola, M, Macgregor, R B, Zhang, X Y, Friedman, J M
A new spectroscopic technique is presented for obtaining infraredlike spectra of the binding sites of Ca2+ and other metals in biological macromolecules. The technique, based on the Ca(2+)-like...
Falconi, M, Desideri, A, Cupane, A, Leone, M, Ciccotti, G, Peterson, E S, ...
Molecular dynamics simulations, low temperature visible absorption spectroscopy, and resonance Raman spectroscopy have been performed on a mutant of the Scapharca inaequivalvis homodimeric...
CHARGE TRANSFER STABILIZATION OF HEMOGLOBIN STRUCTURES
Rousseau, D. L., Shelnutt, J. A., Friedman, J. M., Henry, E. R., Simon, S. R.
Van Allen, M I, Fraser, F C, Dallaire, L, Allanson, J, McLeod, D R, Andermann, E, ...
OBJECTIVE: To prevent the recurrence of neural tube defects (NTDs) in families at increased risk of having offspring with NTDs with the use of periconceptional folic acid supplementation. OPTIONS:...
Rinchik, E. M., Bell, J. A., Hunsicker, P. R., Friedman, J. M., Jackson, I. J., Russell, L. B.
Over a period of many years, germ-cell mutagenesis experiments using the mouse specific-locus test have generated numerous radiation- and chemical-induced alleles of the brown (b; Tyrp1) locus in...
Gorski, S M, Adams, K J, Birch, P H, Friedman, J M, Goodfellow, P J
Human craniofacial malformations are a class of common congenital anomalies in which the etiology is heterogeneous and often poorly understood. To better delineate the molecular basis of craniofacial...
Unaffected carrier males in families with fragile X syndrome.
Howard-Peebles, P N, Friedman, J M
Males who transmit the fragile X chromosome but are themselves clinically normal have occasionally been observed. We have studied three families segregating the fragile X. In one family, there are...
Maffei, M, Fei, H, Lee, G H, Dani, C, Leroy, P, Zhang, Y, ...
The gene product of the recently cloned mouse obese gene (ob) is important in regulating adipose tissue mass. ob RNA is expressed specifically by mouse adipocytes in vivo in each of several different...
Smerdon, S J, Jäger, J, Wang, J, Kohlstaedt, L A, Chirino, A J, Friedman, J M, ...
The dipyridodiazepinone Nevirapine is a potent and highly specific inhibitor of the reverse transcriptase (RT) from human immunodeficiency virus type 1 (HIV-1). It is a member of an important class...
Wang, J, Smerdon, S J, Jäger, J, Kohlstaedt, L A, Rice, P A, Friedman, J M, ...
The reverse transcriptase from human immunodeficiency virus type 1 is a heterodimer consisting of one 66-kDa and one 51-kDa subunit. The p66 subunit contains both a polymerase and an RNase H domain;...
Truett, G E, Bahary, N, Friedman, J M, Leibel, R L
The autosomal recessive mutations fa (rat) and db (mouse) cause obesity syndromes that develop early and ultimately become severe. Although both fa/fa rats and db/db mice have been studied...
Molecular mapping of the mouse db mutation.
Bahary, N, Leibel, R L, Joseph, L, Friedman, J M
Diabetes (db) is an autosomal recessive mutation located in the midportion of mouse chromosome 4 that results in profound obesity with hyperphagia, increased metabolic efficiency, and insulin...
Medical genetics: 1. Clinical teratology in the age of genomics
Polifka, Janine E., Friedman, J.M.
Teratogenic exposures are those that can cause an embryo or fetus to develop abnormally. Several factors determine whether an agent is teratogenic, including the gestational timing of the exposure,...
Cocrystal structure of an editing complex of Klenow fragment with DNA.
Freemont, P S, Friedman, J M, Beese, L S, Sanderson, M R, Steitz, T A
High-resolution crystal structures of editing complexes of both duplex and single-stranded DNA bound to Escherichia coli DNA polymerase I large fragment (Klenow fragment) show four nucleotides of...
Vitale, M, Vashishtha, A, Linzer, E, Powell, D J, Friedman, J M
In this paper we describe experiments that address specific issues concerning the regulation of the mouse cholecystokinin gene in brain and intestine. The mouse cholecystokinin gene was cloned and...
We present evidence that differences in the levels of N-myc mRNA among different cell types are the result of posttranscriptional control. First, we noted that while steady-state mouse N-myc mRNA...
Friedman, J M, Babiss, L E, Clayton, D F, Darnell, J E
Recombinant adenoviruses were constructed in which the viral E1A gene was deleted and the E1B promoter was replaced by the rat albumin, mouse beta-major globin, or mouse immunoglobulin heavy-chain...
Babiss, L E, Friedman, J M, Darnell, J E
In the accompanying paper (Friedman et al., Mol. Cell. Biol. 6:3791-3797, 1986), hepatoma-specific expression of the rat albumin promoter within the adenovirus genome was demonstrated. However, the...
Predictors of the Risk of Mortality in Neurofibromatosis 2
Baser, Michael E., Friedman, J. M., Aeschliman, Dana, Joe, Harry, Wallace, Andrew J., Ramsden, Richard T., ...
To evaluate clinical and molecular predictors of the risk of mortality in people with neurofibromatosis 2 (NF2), we analyzed the mortality experience of 368 patients from 261 families in the United...
Babiss, L E, Bennett, A, Friedman, J M, Darnell, J E
As tested by DNase I digestion, the chromatin structure in several regions 5' to the rat serum albumin gene varies in tissues and cell lines that differ in transcription rate of this gene. Three...
Expression of the cholecystokinin gene in pediatric tumors.
Friedman, J M, Vitale, M, Maimon, J, Israel, M A, Horowitz, M E, Schneider, B S
We have examined a wide range of cultured human tumor cell lines and found that a specific subset of tumors expresses the cholecystokinin (CCK) gene. All neuroepitheliomas (eight) and Ewing sarcoma...
Protein-heme interaction in hemoglobin: evidence from Raman difference spectroscopy.
Shelnutt, J A, Rousseau, D L, Friedman, J M, Simon, S R
Raman difference spectroscopy measurements on native and chemically modified human deoxyhemoglobins stabilized in either the R or the T quaternary structure revealed frequency differences in the...
Friedman, J M, Rousseau, D L, Adar, F
Resonance Raman scattering excitation profile data have been obtained on ferrocytochromes c and b5 in the alpha absorption band region. We observe in cytochrome c that the shape of the excitation...
Friedman, J M, Babiss, L E, Weiss, M, Darnell, J E
A series of rat hepatoma cell lines was infected with a recombinant adenovirus bearing the rat albumin promoter. Transcription from this promoter was scored directly and was highest in FAO, the...
Improving the Prediction of Complex Diseases by Testing for Multiple Disease-Susceptibility Genes
Yang, Quanhe, Khoury, Muin J., Botto, Lorenzo, Friedman, J. M., Flanders, W. Dana
Studies have argued that genetic testing will provide limited information for predicting the probability of common diseases, because of the incomplete penetrance of genotypes and the low magnitude of...
Rinchik, E. M., Bell, J. A., Hunsicker, P. R., Friedman, J. M., Jackson, I. J., Russell, L. B.
Over a period of many years, germ-cell mutagenesis experiments using the mouse specific-locus test have generated numerous radiation- and chemical-induced alleles of the brown (b; Tyrp1) locus in...
Baser, Michael E., Kuramoto, Lisa, Joe, Harry, Friedman, J. M., Wallace, Andrew J., Gillespie, James E., ...
Neurofibromatosis 2 (NF2) is an autosomal dominant disease that is characterized by tumors on the vestibular branch of the VIII cranial nerve, but other types of nervous system tumors usually occur...
Huang, J, Leone, M, Boffi, A, Friedman, J M, Chiancone, E
The near-infrared charge transfer band at 760 nm (band III) has been investigated in deoxy and photodissociated dimeric Scapharca hemoglobin. At 300 K, the 10-ns spectrum of the carbonmonoxy...
Mortality in Neurofibromatosis 1: An Analysis Using U.S. Death Certificates
Rasmussen, Sonja A., Yang, Quanhe, Friedman, J. M.
Although neurofibromatosis 1 (NF1) is a relatively common autosomal dominant condition, information about its effect on mortality is limited. We used Multiple-Cause Mortality Files, compiled from...
Carboxy Mb at pH 3. Time-resolved resonance Raman study at cryogenic temperatures.
Iben, I E, Cowen, B R, Sanches, R, Friedman, J M
Cryogenic samples of MbCO at pH3 are studied using nanosecond and picosecond time-resolved resonance Raman spectroscopy. It is observed that under excitation conditions sufficient to completely...
Iben, I E, Stavola, M, Macgregor, R B, Zhang, X Y, Friedman, J M
A new spectroscopic technique is presented for obtaining infraredlike spectra of the binding sites of Ca2+ and other metals in biological macromolecules. The technique, based on the Ca(2+)-like...
Falconi, M, Desideri, A, Cupane, A, Leone, M, Ciccotti, G, Peterson, E S, ...
Molecular dynamics simulations, low temperature visible absorption spectroscopy, and resonance Raman spectroscopy have been performed on a mutant of the Scapharca inaequivalvis homodimeric...
CHARGE TRANSFER STABILIZATION OF HEMOGLOBIN STRUCTURES
Rousseau, D. L., Shelnutt, J. A., Friedman, J. M., Henry, E. R., Simon, S. R.
Van Allen, M I, Fraser, F C, Dallaire, L, Allanson, J, McLeod, D R, Andermann, E, ...
OBJECTIVE: To prevent the recurrence of neural tube defects (NTDs) in families at increased risk of having offspring with NTDs with the use of periconceptional folic acid supplementation. OPTIONS:...
Gorski, S M, Adams, K J, Birch, P H, Friedman, J M, Goodfellow, P J
Human craniofacial malformations are a class of common congenital anomalies in which the etiology is heterogeneous and often poorly understood. To better delineate the molecular basis of craniofacial...
Unaffected carrier males in families with fragile X syndrome.
Howard-Peebles, P N, Friedman, J M
Males who transmit the fragile X chromosome but are themselves clinically normal have occasionally been observed. We have studied three families segregating the fragile X. In one family, there are...