J. Allan Downie

Identification of protein secretion systems and novel secreted proteins in Rhizobium leguminosarumbv. viciae (2008)

Krehenbrink, Martin, Downie, J Allan

Abstract Background Proteins secreted by bacteria play an important role in infection of eukaryotic hosts. Rhizobia infect the roots of leguminous plants and establish a mutually beneficial...

Protein domains and architectural innovation in plant-associated Proteobacteria (2005)

Studholme, David J, Downie, J Allan, Preston, Gail M

Abstract Background Evolution of new complex biological behaviour tends to arise by novel combinations of existing building blocks. The functional and evolutionary building blocks of the proteome are...

Protein domains and architectural innovation in plant-associated Proteobacteria (2005)

Studholme, David J, Downie, J Allan, Preston, Gail M

Background Evolution of new complex biological behaviour tends to arise by novel combinations of existing building blocks. The functional and evolutionary building blocks of the proteome are protein...

Dissection of nodulation signaling using pea mutants defective for calcium spiking induced by Nod factors and chitin oligomers

Walker, Simon A., Viprey, Virginie, Downie, J. Allan

Changes in intracellular calcium in pea root hairs responding to Rhizobium leguminosarum bv. viciae nodulation (Nod) factors were analyzed by using a microinjected calcium-sensitive fluorescent dye...

Analysis of Quorum-Sensing-Dependent Control of Rhizosphere-Expressed (rhi) Genes in Rhizobium leguminosarum bv. viciae

Rodelas, Belen, Lithgow, James K., Wisniewski-Dye, Florence, Hardman, Andrea, Wilkinson, Adam, Economou, Anastassios, ...

The rhi genes of Rhizobium leguminosarum biovar viciae are expressed in the rhizosphere and play a role in the interaction with legumes, such as the pea. Previously (K. M. Gray, J. P. Pearson, J. A....

Extracellular Glycanases of Rhizobium leguminosarum Are Activated on the Cell Surface by an Exopolysaccharide-Related Component

Zorreguieta, Angeles, Finnie, Christine, Downie, J. Allan

Rhizobium leguminosarum secretes two extracellular glycanases, PlyA and PlyB, that can degrade exopolysaccharide (EPS) and carboxymethyl cellulose (CMC), which is used as a model substrate of plant...

Enhanced Symbiotic Performance by Rhizobium tropici Glycogen Synthase Mutants

Marroquí, Silvia, Zorreguieta, Angeles, Santamaría, Carmen, Temprano, Francisco, Soberón, Mario, Megías, Manuel, ...

We isolated a Tn5-induced Rhizobium tropici mutant that has enhanced capacity to oxidize N,N-dimethyl-p-phenylendiamine (DMPD) and therefore has enhanced respiration via cytochrome oxidase. The...

Exopolysaccharide II Production Is Regulated by Salt in the Halotolerant Strain Rhizobium meliloti EFB1

Lloret, Javier, Wulff, Brande B. H., Rubio, Jose M., Downie, J. Allan, Bonilla, Ildefonso, Rivilla, Rafael

The halotolerant strain Rhizobium meliloti EFB1 modifies the production of extracellular polysaccharides in response to salt. EFB1 colonies grown in the presence of 0.3 M NaCl show a decrease in...

Characterization of Rhizobium leguminosarum Exopolysaccharide Glycanases That Are Secreted via a Type I Exporter and Have a Novel Heptapeptide Repeat Motif

Finnie, Christine, Zorreguieta, Angeles, Hartley, Nigel M., Downie, J. Allan

The prsDE genes encode a type I protein secretion system required for the secretion of the nodulation protein NodO and at least three other proteins from Rhizobium leguminosarum bv. viciae. At least...

Energy Supply for Active Transport in Anaerobically Grown Escherichia coli

Boonstra, Johannes, Downie, J. Allan, Konings, Wil N.

Escherichia coli K-12, grown under anaerobic conditions with glucose as the sole source of carbon and energy without any terminal electron acceptor added, contains a fumarate reductase system in...

Subunits of the Adenosine Triphosphatase Complex Translated In Vitro from the Escherichia coli unc Operon

Downie, J. Allan, Langman, Lyndall, Cox, Graeme B., Yanofsky, Charles, Gibson, Frank

The unc operon of Escherichia coli was split into two fragments by the restriction endonuclease HindIII. The operator-proximal portion was cloned into plasmid pACYC184, forming plasmid pAN51, which...

A Ca2+/calmodulin-dependent protein kinase required for symbiotic nodule development: Gene identification by transcript-based cloning

Mitra, Raka M., Gleason, Cynthia A., Edwards, Anne, Hadfield, James, Downie, J. Allan, Oldroyd, Giles E. D., ...

In the establishment of the legume-rhizobial symbiosis, bacterial lipochitooligosaccharide signaling molecules termed Nod factors activate the formation of a novel root organ, the nodule. Nod factors...

Cloning of the symbiotic region of Rhizobium leguminosarum: the nodulation genes are between the nitrogenase genes and a nifA-like gene

Downie, J.Allan, Ma, Qing-Sheng, Knight, Celia D., Hombrecher, Gerd, Johnston, Andrew W.B.

The region of the Rhizobium leguminosarum plasmid pRL1JI involved in nodulation and nitrogen fixation has been cloned on a series of four overlapping cosmid clones. These clones represent ˜60 kb of...

The reconstitution of functional respiratory chains in membranes from electron-transport-deficient mutants of Escherichia coli as demonstrated by quenching of atebrin fluorescence (Short Communication)

Haddock, Bruce A., Downie, J. Allan

Measurements were made of electron-transport-dependent quenching of atebrin fluorescence in particles prepared from mutants of Escherichia coli unable to synthesize either ubiquinone or haem. Such...

A nucleoporin is required for induction of Ca2+ spiking in legume nodule development and essential for rhizobial and fungal symbiosis

Kanamori, Norihito, Madsen, Lene Heegaard, Radutoiu, Simona, Frantescu, Mirela, Quistgaard, Esben M. H., Miwa, Hiroki, ...

Nuclear-cytoplasmic partitioning and traffic between cytoplasmic and nuclear compartments are fundamental processes in eukaryotic cells. Nuclear pore complexes mediate transport of proteins, RNAs and...

Proteins Exported via the PrsD-PrsE Type I Secretion System and the Acidic Exopolysaccharide Are Involved in Biofilm Formation by Rhizobium leguminosarum

Russo, Daniela M., Williams, Alan, Edwards, Anne, Posadas, Diana M., Finnie, Christine, Dankert, Marcelo, ...

The type I protein secretion system of Rhizobium leguminosarum bv. viciae encoded by the prsD and prsE genes is responsible for secretion of the exopolysaccharide (EPS)-glycanases PlyA and PlyB. The...

Dissection of nodulation signaling using pea mutants defective for calcium spiking induced by Nod factors and chitin oligomers

Walker, Simon A., Viprey, Virginie, Downie, J. Allan

Changes in intracellular calcium in pea root hairs responding to Rhizobium leguminosarum bv. viciae nodulation (Nod) factors were analyzed by using a microinjected calcium-sensitive fluorescent dye...

Analysis of Quorum-Sensing-Dependent Control of Rhizosphere-Expressed (rhi) Genes in Rhizobium leguminosarum bv. viciae

Rodelas, Belen, Lithgow, James K., Wisniewski-Dye, Florence, Hardman, Andrea, Wilkinson, Adam, Economou, Anastassios, ...

The rhi genes of Rhizobium leguminosarum biovar viciae are expressed in the rhizosphere and play a role in the interaction with legumes, such as the pea. Previously (K. M. Gray, J. P. Pearson, J. A....

Extracellular Glycanases of Rhizobium leguminosarum Are Activated on the Cell Surface by an Exopolysaccharide-Related Component

Zorreguieta, Angeles, Finnie, Christine, Downie, J. Allan

Rhizobium leguminosarum secretes two extracellular glycanases, PlyA and PlyB, that can degrade exopolysaccharide (EPS) and carboxymethyl cellulose (CMC), which is used as a model substrate of plant...

Enhanced Symbiotic Performance by Rhizobium tropici Glycogen Synthase Mutants

Marroquí, Silvia, Zorreguieta, Angeles, Santamaría, Carmen, Temprano, Francisco, Soberón, Mario, Megías, Manuel, ...

We isolated a Tn5-induced Rhizobium tropici mutant that has enhanced capacity to oxidize N,N-dimethyl-p-phenylendiamine (DMPD) and therefore has enhanced respiration via cytochrome oxidase. The...

Exopolysaccharide II Production Is Regulated by Salt in the Halotolerant Strain Rhizobium meliloti EFB1

Lloret, Javier, Wulff, Brande B. H., Rubio, Jose M., Downie, J. Allan, Bonilla, Ildefonso, Rivilla, Rafael

The halotolerant strain Rhizobium meliloti EFB1 modifies the production of extracellular polysaccharides in response to salt. EFB1 colonies grown in the presence of 0.3 M NaCl show a decrease in...

Characterization of Rhizobium leguminosarum Exopolysaccharide Glycanases That Are Secreted via a Type I Exporter and Have a Novel Heptapeptide Repeat Motif

Finnie, Christine, Zorreguieta, Angeles, Hartley, Nigel M., Downie, J. Allan

The prsDE genes encode a type I protein secretion system required for the secretion of the nodulation protein NodO and at least three other proteins from Rhizobium leguminosarum bv. viciae. At least...

Energy Supply for Active Transport in Anaerobically Grown Escherichia coli

Boonstra, Johannes, Downie, J. Allan, Konings, Wil N.

Escherichia coli K-12, grown under anaerobic conditions with glucose as the sole source of carbon and energy without any terminal electron acceptor added, contains a fumarate reductase system in...

Subunits of the Adenosine Triphosphatase Complex Translated In Vitro from the Escherichia coli unc Operon

Downie, J. Allan, Langman, Lyndall, Cox, Graeme B., Yanofsky, Charles, Gibson, Frank

The unc operon of Escherichia coli was split into two fragments by the restriction endonuclease HindIII. The operator-proximal portion was cloned into plasmid pACYC184, forming plasmid pAN51, which...

A Ca2+/calmodulin-dependent protein kinase required for symbiotic nodule development: Gene identification by transcript-based cloning

Mitra, Raka M., Gleason, Cynthia A., Edwards, Anne, Hadfield, James, Downie, J. Allan, Oldroyd, Giles E. D., ...

In the establishment of the legume-rhizobial symbiosis, bacterial lipochitooligosaccharide signaling molecules termed Nod factors activate the formation of a novel root organ, the nodule. Nod factors...

Cloning of the symbiotic region of Rhizobium leguminosarum: the nodulation genes are between the nitrogenase genes and a nifA-like gene

Downie, J.Allan, Ma, Qing-Sheng, Knight, Celia D., Hombrecher, Gerd, Johnston, Andrew W.B.

The region of the Rhizobium leguminosarum plasmid pRL1JI involved in nodulation and nitrogen fixation has been cloned on a series of four overlapping cosmid clones. These clones represent ˜60 kb of...

The reconstitution of functional respiratory chains in membranes from electron-transport-deficient mutants of Escherichia coli as demonstrated by quenching of atebrin fluorescence (Short Communication)

Haddock, Bruce A., Downie, J. Allan

Measurements were made of electron-transport-dependent quenching of atebrin fluorescence in particles prepared from mutants of Escherichia coli unable to synthesize either ubiquinone or haem. Such...

A nucleoporin is required for induction of Ca2+ spiking in legume nodule development and essential for rhizobial and fungal symbiosis

Kanamori, Norihito, Madsen, Lene Heegaard, Radutoiu, Simona, Frantescu, Mirela, Quistgaard, Esben M. H., Miwa, Hiroki, ...

Nuclear-cytoplasmic partitioning and traffic between cytoplasmic and nuclear compartments are fundamental processes in eukaryotic cells. Nuclear pore complexes mediate transport of proteins, RNAs and...

Proteins Exported via the PrsD-PrsE Type I Secretion System and the Acidic Exopolysaccharide Are Involved in Biofilm Formation by Rhizobium leguminosarum

Russo, Daniela M., Williams, Alan, Edwards, Anne, Posadas, Diana M., Finnie, Christine, Dankert, Marcelo, ...

The type I protein secretion system of Rhizobium leguminosarum bv. viciae encoded by the prsD and prsE genes is responsible for secretion of the exopolysaccharide (EPS)-glycanases PlyA and PlyB. The...

Lotus japonicus Nodulation Requires Two GRAS Domain Regulators, One of Which Is Functionally Conserved in a Non-Legume1[C][W]

Heckmann, Anne B., Lombardo, Fabien, Miwa, Hiroki, Perry, Jillian A., Bunnewell, Sue, Parniske, Martin, ...

A new nodulation-defective mutant of Lotus japonicus does not initiate nodule cortical cell division in response to Mesorhizobium loti, but induces root hair deformation, Nod factor-induced calcium...

NUCLEOPORIN85 Is Required for Calcium Spiking, Fungal and Bacterial Symbioses, and Seed Production in Lotus japonicus

Saito, Katsuharu, Yoshikawa, Makoto, Yano, Koji, Miwa, Hiroki, Uchida, Hisaki, Asamizu, Erika, ...

In Lotus japonicus, seven genetic loci have been identified thus far as components of a common symbiosis (Sym) pathway shared by rhizobia and arbuscular mycorrhizal fungi. We characterized the nup85...

Mastoparan Activates Calcium Spiking Analogous to Nod Factor-Induced Responses in Medicago truncatula Root Hair Cells1[W][OA]

Sun, Jongho, Miwa, Hiroki, Downie, J. Allan, Oldroyd, Giles E.D.

The rhizobial-derived signaling molecule Nod factor is essential for the establishment of the Medicago truncatula/Sinorhizobium meliloti symbiosis. Nod factor perception and signal transduction in...

A Common Genomic Framework for a Diverse Assembly of Plasmids in the Symbiotic Nitrogen Fixing Bacteria

Crossman, Lisa C., Castillo-Ramírez, Santiago, McAnnula, Craig, Lozano, Luis, Vernikos, Georgios S., Acosta, José L., ...

This work centres on the genomic comparisons of two closely-related nitrogen-fixing symbiotic bacteria, Rhizobium leguminosarum biovar viciae 3841 and Rhizobium etli CFN42. These strains maintain a...

The Medicago truncatula DMI1 Protein Modulates Cytosolic Calcium Signaling1[W][OA]

Peiter, Edgar, Sun, Jongho, Heckmann, Anne B., Venkateshwaran, Muthusubramanian, Riely, Brendan K., Otegui, Marisa S., ...

In addition to establishing symbiotic relationships with arbuscular mycorrhizal fungi, legumes also enter into a nitrogen-fixing symbiosis with rhizobial bacteria that results in the formation of...

Glucomannan-Mediated Attachment of Rhizobium leguminosarum to Pea Root Hairs Is Required for Competitive Nodule Infection▿

Williams, Alan, Wilkinson, Adam, Krehenbrink, Martin, Russo, Daniela M., Zorreguieta, Angeles, Downie, J. Allan

The Rhizobium leguminosarum biovar viciae genome contains several genes predicted to determine surface polysaccharides. Mutants predicted to affect the initial steps of polysaccharide synthesis were...