Isobella Honeyborne

Proliferative Capacity of Epitope-Specific CD8 T-Cell Responses Is Inversely Related to Viral Load in Chronic Human Immunodeficiency Virus Type 1 Infection▿

Day, Cheryl L., Kiepiela, Photini, Leslie, Alasdair J., Van Der Stok, Mary, Nair, Kriebashne, Ismail, Nasreen, ...

The relationship between the function of human immunodeficiency virus (HIV)-specific CD8 T-cell responses and viral load has not been defined. In this study, we used a panel of major...

Control of Human Immunodeficiency Virus Type 1 Is Associated with HLA-B*13 and Targeting of Multiple Gag-Specific CD8+ T-Cell Epitopes▿

Honeyborne, Isobella, Prendergast, Andrew, Pereyra, Florencia, Leslie, Alasdair, Crawford, Hayley, Payne, Rebecca, ...

To better understand relationships between CD8+ T-cell specificity and the immune control of human immunodeficiency virus type 1 (HIV-1), we analyzed the role of HLA-B*13, an allele associated with...

Compensatory Mutation Partially Restores Fitness and Delays Reversion of Escape Mutation within the Immunodominant HLA-B*5703-Restricted Gag Epitope in Chronic Human Immunodeficiency Virus Type 1 Infection▿

Crawford, Hayley, Prado, Julia G., Leslie, Alasdair, Hué, Stéphane, Honeyborne, Isobella, Reddy, Sharon, ...

HLA-B*5703 is associated with effective immune control in human immunodeficiency virus type 1 (HIV-1) infection. Here we describe an escape mutation within the immunodominant HLA-B*5703-restricted...

Transmission and accumulation of CTL escape variants drive negative associations between HIV polymorphisms and HLA

Leslie, Alasdair, Kavanagh, Daniel, Honeyborne, Isobella, Pfafferott, Katja, Edwards, Charles, Pillay, Tilly, ...

Human immunodeficiency virus (HIV)-1 amino acid sequence polymorphisms associated with expression of specific human histocompatibility leukocyte antigen (HLA) class I alleles suggest sites of...

Compensatory Mutation Partially Restores Fitness and Delays Reversion of Escape Mutation within the Immunodominant HLA-B*5703-Restricted Gag Epitope in Chronic Human Immunodeficiency Virus Type 1 Infection

Crawford, Hayley, Prado, Julia G., Leslie, Alasdair, Hué, Stéphane, Honeyborne, Isobella, Reddy, Sharon, ...