Isabelle Callebaut

Characterization of Non-Trivial Neighborhood Fold Constraints from Protein Sequences using Generalized Topohydrophobicity (9999)

Guillaume Fourty, Isabelle Callebaut, Jean-Paul Mornon

Prediction of key features of protein structures, such as secondary structure, solvent accessibility and number of contacts between residues, provides useful structural constraints for comparative...

GPR50 is the mammalian ortholog of Mel1c: Evidence of rapid evolution in mammals (2008)

Dufourny, Laurence, Levasseur, Anthony, Migaud, Martine, Callebaut, Isabelle, Pontarotti, Pierre, Malpaux, Benoit, ...

Abstract Background The melatonin receptor subfamily contains three members Mel1a, Mel1b and Mel1c, found in all vertebrates except for Mel1c which is found only in fish, Xenopus species and the...

Characterization of Non-Trivial Neighborhood Fold Constraints from Protein Sequences using Generalized Topohydrophobicity (2008)

Guillaume Fourty, Isabelle Callebaut, Jean-Paul Mornon

Prediction of key features of protein structures, such as secondary structure, solvent accessibility and number of contacts between residues, provides useful structural constraints for comparative...

The checkpoint Saccharomyces cerevisiae Rad9 protein contains a tandem tudor domain that recognizes DNA. (2007)

Lancelot, Nathalie, Charier, Gaëlle, Couprie, Joël, Duband-Goulet, Isabelle, Alpha-Bazin, Béatrice, Quémeneur, Eric, ...

DNA damage checkpoints are signal transduction pathways that are activated after genotoxic insults to protect genomic integrity. At the site of DNA damage, 'mediator' proteins are in charge of...

The checkpoint Saccharomyces cerevisiae Rad9 protein contains a tandem tudor domain that recognizes DNA. (2007)

Lancelot, Nathalie, Charier, Gaëlle, Couprie, Joël, Duband-Goulet, Isabelle, Alpha-Bazin, Béatrice, Quémeneur, Eric, ...

DNA damage checkpoints are signal transduction pathways that are activated after genotoxic insults to protect genomic integrity. At the site of DNA damage, 'mediator' proteins are in charge of...

A generalized analysis of hydrophobic and loop clusters within globular protein sequences (2007)

Eudes, Richard, Le Tuan, Khanh, Delettré, Jean, Mornon, Jean-Paul, Callebaut, Isabelle

Abstract Background Hydrophobic Cluster Analysis (HCA) is an efficient way to compare highly divergent sequences through the implicit secondary structure information directly derived from hydrophobic...

Identification, characterization and metagenome analysis of oocyte-specific genes organized in clusters in the mouse genome. (2006)

Paillisson, Amélie, Dadé, Sébastien, Callebaut, Isabelle, Bontoux, Martine, Dalbiès-Tran, Rozenn, Vaiman, Daniel, ...

BACKGROUND: Genes specifically expressed in the oocyte play key roles in oogenesis, ovarian folliculogenesis, fertilization and/or early embryonic development. In an attempt to identify novel...

Identification, characterization and metagenome analysis of oocyte-specific genes organized in clusters in the mouse genome. (2006)

Paillisson, Amélie, Dadé, Sébastien, Callebaut, Isabelle, Bontoux, Martine, Dalbiès-Tran, Rozenn, Vaiman, Daniel, ...

BACKGROUND: Genes specifically expressed in the oocyte play key roles in oogenesis, ovarian folliculogenesis, fertilization and/or early embryonic development. In an attempt to identify novel...

ATP Hydrolysis Is Essential for the Function of the Uup ATPbinding Cassette ATPase in Precise Excision of Transposons. (2006)

Murat, Dorothée, Bance, Pierre, Callebaut, Isabelle, Dassa, Elie

In Escherichia coli K-12, the RecA- and transposase-independent precise excision of transposons is thought to be mediated by the slippage of the DNA polymerase between the two short direct repeats...

Common antigenicity for two glycosidases. (2006)

Kakavanos, Revecca, Lehn, Pierre, Callebaut, Isabelle, Meiklea, Peter J., Parkinson-Lawrence, Emma J., Hopwood, John J., ...

Enzyme replacement therapy (ERT) has proven to be an effective therapy for some lysosomal storage disorder (LSD) patients. A potential complication during ERT is the generation of an immune response...

Structural and Functional Characterization of the TgDRE Multidomain Protein, a DNA Repair Enzyme from Toxoplasma gondii. (2006)

Frénal, Karine, Callebaut, Isabelle, Wecker, Karine, Prochnicka-Chalufour, Ada, Dendouga, Najoua, Zinn-Justin, Sophie, ...

The parasite Toxoplasma gondii expresses a 55 kDa protein or TgDRE that belongs to a novel family of proteins characterized by the presence of three domains, a human splicing factor 45-like motif...

Cernunnos Interacts with the XRCC4 DNA-ligase IV Complex and Is Homologous to the Yeast Nonhomologous End-joining Factor Nej1. (2006)

Callebaut, Isabelle, Malivert, Laurent, Fischer, Alain, Mornon, Jean-Paul, Revy, Patrick, De Villartay, Jean-Pierre

DNA double strand breaks are considered as the most harmful DNA lesions and are repaired by either homologous recombination or nonhomologous end joining (NHEJ). A new NHEJ factor, Cernunnos, has been...

Common antigenicity for two glycosidases (2006)

Kakavanos, Revecca, Lehn, Pierre, Callebaut, Isabelle, Meikle, Peter J, Parkinson-Lawrence, Emma Jane, Hopwood, John J, ...

Prediction of the general transcription factors associated with RNA polymerase II in Plasmodium falciparum: conserved features and differences relative to other eukaryotes (2005)

Callebaut, Isabelle, Prat, Karine, Meurice, Edwige, Mornon, Jean-Paul, Tomavo, Stanislas

Abstract Background To date, only a few transcription factors have been identified in the genome of the parasite Plasmodium falciparum , the causative agent of malaria. Moreover, no detailed...

Identification, characterization and metagenome analysis of oocyte-specific genes organized in clusters in the mouse genome (2005)

Paillisson, Amélie, Dadé, Sébastien, Callebaut, Isabelle, Bontoux, Martine, Dalbiès-Tran, Rozenn, Vaiman, Daniel, ...

Abstract Background Genes specifically expressed in the oocyte play key roles in oogenesis, ovarian folliculogenesis, fertilization and/or early embryonic development. In an attempt to identify novel...

Identification of the hydrophobic strand in the A–B loop of leptin as major binding site III: implications for large-scale preparation of potent recombinant human and ovine leptin antagonists. (2005)

Niv-Spector, Leonora, Gonen-Berger, Dana, Gourdou, Isabelle, Biener, Eva, E. Gussakovsky, Eugene, Benomar, Yackir, ...

Interaction of leptin with its receptors resembles that of interleukin-6 and granulocyte colony-stimulating factor, which interact with their receptors through binding sites I–III. Site III plays a...

Identification, characterization and metagenome analysis of oocyte-specific genes organized in clusters in the mouse genome. (2005)

Paillisson, Amélie, Dadé, Sébastien, Callebaut, Isabelle, Bontoux, Martine, Dalbiès-Tran, Rozenn, Vaiman, Daniel, ...

Background Genes specifically expressed in the oocyte play key roles in oogenesis, ovarian folliculogenesis, fertilization and/or early embryonic development. In an attempt to identify novel...

Characterization and study of a κ-casein-like chymosin-sensitive linkage. (2005)

Callebaut, Isabelle, Schoentgen, Françoise, Prat, Karine, Mornon, Jean-Paul, Jollès, Pierre

The present report is dealing with the identification, in various unrelated proteins, of protein fragments sharing local sequence and structure similarities with the chymosin-sensitive linkage...

Prediction of the general transcription factors associated with RNA polymerase II in Plasmodium falciparum: conserved features and differences relative to other eukaryotes. (2005)

Callebaut, Isabelle, Prat, Karine, Meurice, Edwige, Mornon, Jean-Paul, Tomavo, Stanislas

Background To date, only a few transcription factors have been identified in the genome of the parasite Plasmodium falciparum, the causative agent of malaria. Moreover, no detailed molecular analysis...

Molecular basis of methylmalonyl-CoA mutase apoenzyme defect in 40 European patients affected by mut° and mut- forms of methylmalonic acidemia: Identification of 29 novel mutations in the MUT gene. (2005)

Acquaviva, Cécile, Benoist, Jean-François, Pereira, Sabrina, Callebaut, Isabelle, Koskas, Thu, Porquet, Dominique, ...

Methylmalonyl-CoA mutase (MCM) apoenzyme deficiency is a rare metabolic disease that may result in distinct biochemical phenotypes of methylmalonic acidemia (MMA), namely mut° and mut-. We analyzed...

Characterization of a Type III secretion substrate specificity switch (T3S4) domain in YscP from Yersinia enterocolitica. (2005)

Agrain, Céline, Callebaut, Isabelle, Journet, Laure, Sorg, Isabel, Paroz, Cécile, Mota, Luís Jaime, ...

The length of the needle ending the Yersinia Ysc injectisome is determined by YscP, a protein acting as a molecular ruler. In addition, YscP is required for Yop secretion. In the present paper, by a...

Identification, characterization and metagenome analysis of oocyte-specific genes organized in clusters in the mouse genome. (2005)

Paillisson, Amélie, Dadé, Sébastien, Callebaut, Isabelle, Bontoux, Martine, Dalbiès-Tran, Rozenn, Vaiman, Daniel, ...

BACKGROUND: Genes specifically expressed in the oocyte play key roles in oogenesis, ovarian folliculogenesis, fertilization and/or early embryonic development. In an attempt to identify novel...

Mutation in bone morphogenetic protein receptor-IB is associated with increased ovulation rate in Booroola Mérino ewes

Mulsant, Philippe, Lecerf, Frédéric, Fabre, Stéphane, Schibler, Laurent, Monget, Philippe, Lanneluc, Isabelle, ...

Ewes from the Booroola strain of Australian Mérino sheep are characterized by high ovulation rate and litter size. This phenotype is due to the action of the FecBB allele of a major gene named FecB,...

Metallo-β-lactamase fold within nucleic acids processing enzymes: the β-CASP family

Callebaut, Isabelle, Moshous, Despina, Mornon, Jean-Paul, De Villartay, Jean-Pierre

A separate family of enzymes within the metallo-β-lactamase fold comprises several important proteins acting on nucleic acid substrates, involved in DNA repair (Artemis, SNM1 and PSO2) and RNA...

The A14–A43 heterodimer subunit in yeast RNA pol I and their relationship to Rpb4–Rpb7 pol II subunits

Peyroche, Gérald, Levillain, Erwann, Siaut, Magali, Callebaut, Isabelle, Schultz, Patrick, Sentenac, André, ...

A43, an essential subunit of yeast RNA polymerase I (pol I), interacts with Rrn3, a class I general transcription factor required for rDNA transcription. The pol I–Rrn3 complex is the only form of...

An Rpb4/Rpb7-Like Complex in Yeast RNA Polymerase III Contains the Orthologue of Mammalian CGRP-RCP

Siaut, Magali, Zaros, Cécile, Levivier, Emilie, Ferri, Maria-Laura, Court, Magali, Werner, Michel, ...

The essential C17 subunit of yeast RNA polymerase (Pol) III interacts with Brf1, a component of TFIIIB, suggesting a role for C17 in the initiation step of transcription. The protein sequence of C17...

Identification, characterization and metagenome analysis of oocyte-specific genes organized in clusters in the mouse genome

Paillisson, Amélie, Dadé, Sébastien, Callebaut, Isabelle, Bontoux, Martine, Dalbiès-Tran, Rozenn, Vaiman, Daniel, ...

Prediction of the general transcription factors associated with RNA polymerase II in Plasmodium falciparum: conserved features and differences relative to other eukaryotes

Callebaut, Isabelle, Prat, Karine, Meurice, Edwige, Mornon, Jean-Paul, Tomavo, Stanislas

D53 is a novel endosomal SNARE-binding protein that enhances interaction of syntaxin 1 with the synaptobrevin 2 complex in vitro.

Proux-Gillardeaux, Véronique, Galli, Thierry, Callebaut, Isabelle, Mikhailik, Anatoly, Calothy, Georges, Marx, Maria

Synaptobrevin 2 (Sb2), syntaxin1 (Stx1), and synaptosomal-associated protein of 25 kDa (SNAP-25) are the main components of the soluble N -ethylmaleimide-sensitive fusion protein attachment protein...

Bovine Leukemia Virus SU Protein Interacts with Zinc, and Mutations within Two Interacting Regions Differently Affect Viral Fusion and Infectivity In Vivo

Gatot, Jean-Stéphane, Callebaut, Isabelle, Van Lint, Carine, Demonté, Dominique, Kerkhofs, Pierre, Portetelle, Daniel, ...

Bovine leukemia virus (BLV) and human T-cell lymphotropic virus type 1 (HTLV-1) belong to the genus of deltaretroviruses. Their entry into the host cell is supposed to be mediated by interactions of...

Identification of the hydrophobic strand in the A–B loop of leptin as major binding site III: implications for large-scale preparation of potent recombinant human and ovine leptin antagonists

Niv-Spector, Leonora, Gonen-Berger, Dana, Gourdou, Isabelle, Biener, Eva, Gussakovsky, Eugene E., Benomar, Yackir, ...

Interaction of leptin with its receptors resembles that of interleukin-6 and granulocyte colony-stimulating factor, which interact with their receptors through binding sites I–III. Site III plays a...

Mutation in bone morphogenetic protein receptor-IB is associated with increased ovulation rate in Booroola Mérino ewes

Mulsant, Philippe, Lecerf, Frédéric, Fabre, Stéphane, Schibler, Laurent, Monget, Philippe, Lanneluc, Isabelle, ...

Ewes from the Booroola strain of Australian Mérino sheep are characterized by high ovulation rate and litter size. This phenotype is due to the action of the FecBB allele of a major gene named FecB,...

Metallo-β-lactamase fold within nucleic acids processing enzymes: the β-CASP family

Callebaut, Isabelle, Moshous, Despina, Mornon, Jean-Paul, De Villartay, Jean-Pierre

A separate family of enzymes within the metallo-β-lactamase fold comprises several important proteins acting on nucleic acid substrates, involved in DNA repair (Artemis, SNM1 and PSO2) and RNA...

The A14–A43 heterodimer subunit in yeast RNA pol I and their relationship to Rpb4–Rpb7 pol II subunits

Peyroche, Gérald, Levillain, Erwann, Siaut, Magali, Callebaut, Isabelle, Schultz, Patrick, Sentenac, André, ...

A43, an essential subunit of yeast RNA polymerase I (pol I), interacts with Rrn3, a class I general transcription factor required for rDNA transcription. The pol I–Rrn3 complex is the only form of...

An Rpb4/Rpb7-Like Complex in Yeast RNA Polymerase III Contains the Orthologue of Mammalian CGRP-RCP

Siaut, Magali, Zaros, Cécile, Levivier, Emilie, Ferri, Maria-Laura, Court, Magali, Werner, Michel, ...

The essential C17 subunit of yeast RNA polymerase (Pol) III interacts with Brf1, a component of TFIIIB, suggesting a role for C17 in the initiation step of transcription. The protein sequence of C17...

Bovine Leukemia Virus SU Protein Interacts with Zinc, and Mutations within Two Interacting Regions Differently Affect Viral Fusion and Infectivity In Vivo

Gatot, Jean-Stéphane, Callebaut, Isabelle, Van Lint, Carine, Demonté, Dominique, Kerkhofs, Pierre, Portetelle, Daniel, ...

Bovine leukemia virus (BLV) and human T-cell lymphotropic virus type 1 (HTLV-1) belong to the genus of deltaretroviruses. Their entry into the host cell is supposed to be mediated by interactions of...

Identification, characterization and metagenome analysis of oocyte-specific genes organized in clusters in the mouse genome

Paillisson, Amélie, Dadé, Sébastien, Callebaut, Isabelle, Bontoux, Martine, Dalbiès-Tran, Rozenn, Vaiman, Daniel, ...

Prediction of the general transcription factors associated with RNA polymerase II in Plasmodium falciparum: conserved features and differences relative to other eukaryotes

Callebaut, Isabelle, Prat, Karine, Meurice, Edwige, Mornon, Jean-Paul, Tomavo, Stanislas

D53 is a novel endosomal SNARE-binding protein that enhances interaction of syntaxin 1 with the synaptobrevin 2 complex in vitro.

Proux-Gillardeaux, Véronique, Galli, Thierry, Callebaut, Isabelle, Mikhailik, Anatoly, Calothy, Georges, Marx, Maria

Synaptobrevin 2 (Sb2), syntaxin1 (Stx1), and synaptosomal-associated protein of 25 kDa (SNAP-25) are the main components of the soluble N -ethylmaleimide-sensitive fusion protein attachment protein...

Identification of the hydrophobic strand in the A–B loop of leptin as major binding site III: implications for large-scale preparation of potent recombinant human and ovine leptin antagonists

Niv-Spector, Leonora, Gonen-Berger, Dana, Gourdou, Isabelle, Biener, Eva, Gussakovsky, Eugene E., Benomar, Yackir, ...

Interaction of leptin with its receptors resembles that of interleukin-6 and granulocyte colony-stimulating factor, which interact with their receptors through binding sites I–III. Site III plays a...

A generalized analysis of hydrophobic and loop clusters within globular protein sequences

Eudes, Richard, Le Tuan, Khanh, Delettré, Jean, Mornon, Jean-Paul, Callebaut, Isabelle

The discovery of SycO highlights a new function for type III secretion effector chaperones

Letzelter, Michel, Sorg, Isabel, Mota, Luís Jaime, Meyer, Salome, Stalder, Jacqueline, Feldman, Mario, ...

Bacterial injectisomes deliver effector proteins straight into the cytosol of eukaryotic cells (type III secretion, T3S). Many effectors are associated with a specific chaperone that remains inside...

The checkpoint Saccharomyces cerevisiae Rad9 protein contains a tandem tudor domain that recognizes DNA

Lancelot, Nathalie, Charier, Gaëlle, Couprie, Joël, Duband-Goulet, Isabelle, Alpha-Bazin, Béatrice, Quémeneur, Eric, ...

DNA damage checkpoints are signal transduction pathways that are activated after genotoxic insults to protect genomic integrity. At the site of DNA damage, ‘mediator’ proteins are in charge of...

Ubiquitination-Induced Conformational Change within the Deiodinase Dimer Is a Switch Regulating Enzyme Activity▿

Sagar, G. D. Vivek, Gereben, Balázs, Callebaut, Isabelle, Mornon, Jean-Paul, Zeöld, Anikó, Da Silva, Wagner S., ...

Ubiquitination is a critical posttranslational regulator of protein stability and/or subcellular localization. Here we show that ubiquitination can also regulate proteins by transiently inactivating...

NEDD1-dependent recruitment of the γ-tubulin ring complex to the centrosome is necessary for centriole duplication and spindle assembly

Haren, Laurence, Remy, Marie-Hélène, Bazin, Ingrid, Callebaut, Isabelle, Wright, Michel, Merdes, Andreas

The centrosome is the major microtubule organizing structure in somatic cells. Centrosomal microtubule nucleation depends on the protein γ-tubulin. In mammals, γ-tubulin associates with additional...

The Metallo-β-Lactamase/β-CASP Domain of Artemis Constitutes the Catalytic Core for V(D)J Recombination

Poinsignon, Catherine, Moshous, Despina, Callebaut, Isabelle, De Chasseval, Régina, Villey, Isabelle, De Villartay, Jean-Pierre

The V(D)J recombination/DNA repair factor Artemis belongs to the metallo-β-lactamase (β-Lact) superfamily of enzymes. Three regions can be defined within the Artemis protein sequence: (a) the...

GPR50 is the mammalian ortholog of Mel1c: Evidence of rapid evolution in mammals

Dufourny, Laurence, Levasseur, Anthony, Migaud, Martine, Callebaut, Isabelle, Pontarotti, Pierre, Malpaux, Benoit, ...

Multiple pathways inhibit NHEJ at telomeres

Marcand, Stéphane, Pardo, Benjamin, Gratias, Ariane, Cahun, Sabrina, Callebaut, Isabelle

The nonhomologous end-joining (NHEJ) repair pathway is inhibited at telomeres, preventing chromosome fusion. In budding yeast Saccharomyces cerevisiae, the Rap1 protein directly binds the telomere...