Irina G. Minko

Incision of DNA–protein crosslinks by UvrABC nuclease suggests a potential repair pathway involving nucleotide excision repair

Minko, Irina G., Zou, Yue, Lloyd, R. Stephen

DNA–protein crosslinks (DPCs) arise in biological systems as a result of exposure to a variety of chemical and physical agents, many of which are known or suspected carcinogens. The biochemical...

Efficient and Error-Free Replication past a Minor-Groove N2-Guanine Adduct by the Sequential Action of Yeast Rev1 and DNA Polymerase ζ

Washington, M. Todd, Minko, Irina G., Johnson, Robert E., Haracska, Lajos, Harris, Thomas M., Lloyd, R. Stephen, ...

Rev1, a member of the Y family of DNA polymerases, functions in lesion bypass together with DNA polymerase ζ (Polζ). Rev1 is a highly specialized enzyme in that it incorporates only a C opposite...

Efficient and Error-Free Replication Past a Minor-Groove DNA Adduct by the Sequential Action of Human DNA Polymerases ι and κ

Washington, M. Todd, Minko, Irina G., Johnson, Robert E., Wolfle, William T., Harris, Thomas M., Lloyd, R. Stephen, ...

DNA polymerase ι (Polι) is a member of the Y family of DNA polymerases, which promote replication through DNA lesions. The role of Polι in lesion bypass, however, has remained unclear. Polι is...

Human DNA Polymerase ι Promotes Replication through a Ring-Closed Minor-Groove Adduct That Adopts a syn Conformation in DNA

Wolfle, William T., Johnson, Robert E., Minko, Irina G., Lloyd, R. Stephen, Prakash, Satya, Prakash, Louise

Acrolein, an α,β-unsaturated aldehyde, is generated in vivo as the end product of lipid peroxidation and from oxidation of polyamines. The reaction of acrolein with the N2 group of guanine in DNA...

Replication past a trans-4-Hydroxynonenal Minor-Groove Adduct by the Sequential Action of Human DNA Polymerases ι and κ

Wolfle, William T., Johnson, Robert E., Minko, Irina G., Lloyd, R. Stephen, Prakash, Satya, Prakash, Louise

The X-ray crystal structure of human DNA polymerase ι (Polι) has shown that it differs from all known Pols in its dependence upon Hoogsteen base pairing for synthesizing DNA. Hoogsteen base pairing...

DNA Damage Recognition of Mutated Forms of UvrB Proteins in Nucleotide Excision Repair

Zou, Yue, Ma, Huaxian, Shell, Steven M., Yang, Zhengguan, Lloyd, R. Stephen, Minko, Irina G., ...

The DNA repair protein UvrB plays an indispensable role in the stepwise and sequential damage recognition of nucleotide excision repair in Escherichia coli. Our previous studies suggested that UvrB...

The metabolic syndrome resulting from a knockout of the NEIL1 DNA glycosylase

Vartanian, Vladimir, Lowell, Brian, Minko, Irina G., Wood, Thomas G., Ceci, Jeffrey D., George, Shakeeta, ...

Endogenously formed reactive oxygen species continuously damage cellular constituents including DNA. These challenges, coupled with exogenous exposure to agents that generate reactive oxygen species,...

Incision of DNA–protein crosslinks by UvrABC nuclease suggests a potential repair pathway involving nucleotide excision repair

Minko, Irina G., Zou, Yue, Lloyd, R. Stephen

DNA–protein crosslinks (DPCs) arise in biological systems as a result of exposure to a variety of chemical and physical agents, many of which are known or suspected carcinogens. The biochemical...

Efficient and Error-Free Replication past a Minor-Groove N2-Guanine Adduct by the Sequential Action of Yeast Rev1 and DNA Polymerase ζ

Washington, M. Todd, Minko, Irina G., Johnson, Robert E., Haracska, Lajos, Harris, Thomas M., Lloyd, R. Stephen, ...

Rev1, a member of the Y family of DNA polymerases, functions in lesion bypass together with DNA polymerase ζ (Polζ). Rev1 is a highly specialized enzyme in that it incorporates only a C opposite...

Efficient and Error-Free Replication Past a Minor-Groove DNA Adduct by the Sequential Action of Human DNA Polymerases ι and κ

Washington, M. Todd, Minko, Irina G., Johnson, Robert E., Wolfle, William T., Harris, Thomas M., Lloyd, R. Stephen, ...

DNA polymerase ι (Polι) is a member of the Y family of DNA polymerases, which promote replication through DNA lesions. The role of Polι in lesion bypass, however, has remained unclear. Polι is...

Human DNA Polymerase ι Promotes Replication through a Ring-Closed Minor-Groove Adduct That Adopts a syn Conformation in DNA

Wolfle, William T., Johnson, Robert E., Minko, Irina G., Lloyd, R. Stephen, Prakash, Satya, Prakash, Louise

Acrolein, an α,β-unsaturated aldehyde, is generated in vivo as the end product of lipid peroxidation and from oxidation of polyamines. The reaction of acrolein with the N2 group of guanine in DNA...

Replication past a trans-4-Hydroxynonenal Minor-Groove Adduct by the Sequential Action of Human DNA Polymerases ι and κ

Wolfle, William T., Johnson, Robert E., Minko, Irina G., Lloyd, R. Stephen, Prakash, Satya, Prakash, Louise

The X-ray crystal structure of human DNA polymerase ι (Polι) has shown that it differs from all known Pols in its dependence upon Hoogsteen base pairing for synthesizing DNA. Hoogsteen base pairing...

The metabolic syndrome resulting from a knockout of the NEIL1 DNA glycosylase

Vartanian, Vladimir, Lowell, Brian, Minko, Irina G., Wood, Thomas G., Ceci, Jeffrey D., George, Shakeeta, ...

Endogenously formed reactive oxygen species continuously damage cellular constituents including DNA. These challenges, coupled with exogenous exposure to agents that generate reactive oxygen species,...