Positive selection on gene expression in the human brain (2006)
Khaitovich, Philipp, Tang, Kun, Franz, Henriette, Kelso, Janet, Hellmann, Ines, Enard, Wolfgang, ...
Initial sequence of the chimpanzee genome and comparison with the human genome (2005)
Mikkelsen, Tarjei S., Hillier, LaDeana W., Eichler, Evan E., Zody, Michael C., Jaffe, David B., Yang, Shiaw-Pyng, ...
Here we present a draft genome sequence of the common chimpanzee (Pan troglodytes). Through comparison with the human genome, we have generated a largely complete catalogue of the genetic differences...
Why do human diversity levels vary at a megabase scale? (2005)
Hellmann, Ines, Prüfer, Kai, Ji, H. K., Zody, M. C., Pääbo, Svante, Ptak, Susan E.
Parallel patterns of evolution in the genomes and transcriptomes of humans and chimpanzees (2005)
Khaitovich, Philipp, Hellmann, Ines, Enard, Wolfgang, Nowick, Katja, Leinweber, M., Franz, H., ...
A Neutral Model of Transcriptome Evolution (2004)
Philipp Khaitovich, Gunter Weiss, Michael Lachmann, Ines Hellmann, Wolfgang Enard, Bjoern Muetzel, ...
Analysis of differences in gene expression between primate species suggests that the majority of them are selectively neutral and likely to have little or no functional consequences.
A Neutral Model of Transcriptome Evolution (2004)
Philipp Khaitovich, Gunter Weiss, Michael Lachmann, Ines Hellmann, Wolfgang Enard, Bjoern Muetzel, ...
Microarray technologies allow the identification of large numbers of expression differences within and between species. Although environmental and physiological stimuli are clearly responsible for...
Regional Patterns of Gene Expression in Human and Chimpanzee Brains (2004)
Khaitovich, Philipp, Muetzel, Bjoern, She, Xinwei, Lachmann, Michael, Hellmann, Ines, Dietzsch, Janko, ...
DNA sequence and comparative analysis of chimpanzee chromosome 22 (2004)
Watanabe, H., Fujiyama, A., Hattory, M., Taylor, T. D., Toyoda, A., Kuroki, Y., ...
A Neutral Model of Transcriptome Evolution (2004)
Khaitovich, Phillip, Weiss, Gunter, Lachmann, Michael, Hellmann, Ines, Enard, Wolfgang, Muetzel, Bjoern, ...
Microarray technologies allow the identification of large numbers of expression differences within and between species. Although environmental and physiological stimuli are clearly responsible for...
Regional patterns of gene expression in human and chimpanzee brains. (2004)
Khaitovich, Philipp, Muetzel, Bjoern, She, Xinwei, Lachmann, Michael, Hellmann, Ines, Dietzsch, Janko, ...
We have analyzed gene expression in various brain regions of humans and chimpanzees. Within both human and chimpanzee individuals, the transcriptomes of the cerebral cortex are very similar to each...
Selection on human genes as revealed by comparisons to chimpanzee cDNA (2003)
Hellmann, Ines, Zöllner, Sebastian, Enard, Wolfgang, Ebersberger, Ingo, Nickel, Birgit, Pääbo, Svante
Functional genomics in the chimpanzee (2002)
Enard, Wolfgang, Ebersberger, Ingo, Fischer, Anne, Heissig, Florian, Hellmann, Ines, Höffner, Barbara, ...
A Neutral Model of Transcriptome Evolution
Khaitovich, Philipp, Weiss, Gunter, Lachmann, Michael, Hellmann, Ines, Enard, Wolfgang, Muetzel, Bjoern, ...
Microarray technologies allow the identification of large numbers of expression differences within and between species. Although environmental and physiological stimuli are clearly responsible for...
Selection on Human Genes as Revealed by Comparisons to Chimpanzee cDNA
Hellmann, Ines, Zöllner, Sebastian, Enard, Wolfgang, Ebersberger, Ingo, Nickel, Birgit, Pääbo, Svante
To better understand the evolutionary forces that affect human genes, we sequenced 5055 expressed sequence tags from the chimpanzee and compared them to their human counterparts. In conjunction with...
Regional Patterns of Gene Expression in Human and Chimpanzee Brains
Khaitovich, Philipp, Muetzel, Bjoern, She, Xinwei, Lachmann, Michael, Hellmann, Ines, Dietzsch, Janko, ...
We have analyzed gene expression in various brain regions of humans and chimpanzees. Within both human and chimpanzee individuals, the transcriptomes of the cerebral cortex are very similar to each...
Why do human diversity levels vary at a megabase scale?
Hellmann, Ines, Prüfer, Kay, Ji, Hongkai, Zody, Michael C., Pääbo, Svante, Ptak, Susan E.
Levels of diversity vary across the human genome. This variation is caused by two forces: differences in mutation rates and the differential impact of natural selection. Pertinent to the question of...
A Neutral Model of Transcriptome Evolution
Khaitovich, Philipp, Weiss, Gunter, Lachmann, Michael, Hellmann, Ines, Enard, Wolfgang, Muetzel, Bjoern, ...
Microarray technologies allow the identification of large numbers of expression differences within and between species. Although environmental and physiological stimuli are clearly responsible for...
Selection on Human Genes as Revealed by Comparisons to Chimpanzee cDNA
Hellmann, Ines, Zöllner, Sebastian, Enard, Wolfgang, Ebersberger, Ingo, Nickel, Birgit, Pääbo, Svante
To better understand the evolutionary forces that affect human genes, we sequenced 5055 expressed sequence tags from the chimpanzee and compared them to their human counterparts. In conjunction with...
Regional Patterns of Gene Expression in Human and Chimpanzee Brains
Khaitovich, Philipp, Muetzel, Bjoern, She, Xinwei, Lachmann, Michael, Hellmann, Ines, Dietzsch, Janko, ...
We have analyzed gene expression in various brain regions of humans and chimpanzees. Within both human and chimpanzee individuals, the transcriptomes of the cerebral cortex are very similar to each...
A Neutral Explanation for the Correlation of Diversity with Recombination Rates in Humans
Hellmann, Ines, Ebersberger, Ingo, Ptak, Susan E., Pääbo, Svante, Przeworski, Molly
One of the most striking findings to emerge from the study of genomic patterns of variation is that regions with lower recombination rates tend to have lower levels of intraspecific diversity but not...
Why do human diversity levels vary at a megabase scale?
Hellmann, Ines, Prüfer, Kay, Ji, Hongkai, Zody, Michael C., Pääbo, Svante, Ptak, Susan E.
Levels of diversity vary across the human genome. This variation is caused by two forces: differences in mutation rates and the differential impact of natural selection. Pertinent to the question of...