The prospect of the work presented in this thesis has been to engineer Cre recombinase to recognize and recombine a sequence from an HIV-1 Long Terminal Repeat (LTR), characterize the recombination...
HIV-1 Proviral DNA Excision Using an Evolved Recombinase (2007)
Sarkar, Indrani, Hauber, Ilona, Hauber, Joachim, Buchholz, Frank
HIV-1 integrates into the host chromosome and persists as a provirus flanked by long terminal repeats (LTRs). To date, treatment regimens primarily target the virus enzymes or virus-cell fusion, but...