HuR binding to cytoplasmic mRNA is perturbed by heat shock
Gallouzi, Imed-Eddine, Brennan, Christopher M., Stenberg, Myrna G., Swanson, Maurice S., Eversole, Ashley, Maizels, Nancy, ...
AU-rich elements (AREs) located in the 3′ untranslated region target the mRNAs encoding many protooncoproteins, cytokines, and lymphokines for rapid degradation. HuR, a ubiquitously expressed...
Tourrière, Hélène, Gallouzi, Imed-eddine, Chebli, Karim, Capony, Jean Paul, Mouaikel, John, Van Der Geer, Peter, ...
Mitogen activation of mRNA decay pathways likely involves specific endoribonucleases, such as G3BP, a phosphorylation-dependent endoribonuclease that associates with RasGAP in dividing but not...
Gallouzi, Imed-eddine, Parker, Fabienne, Chebli, Karim, Maurier, Florence, Labourier, Emmanuel, Barlat, Isabelle, ...
A potential p120 GTPase-activating protein (RasGAP) effector, G3BP (RasGAP Src homology 3 [SH3] binding protein), was previously identified based on its ability to bind the SH3 domain of RasGAP. Here...
Labourier, Emmanuel, Bourbon, Henri-Marc, Gallouzi, Imed-eddine, Fostier, Maggy, Allemand, Eric, Tazi, Jamal
Specific recognition of splice sites within metazoan mRNA precursors (pre-mRNAs) is a potential stage for gene regulation by alternative splicing. Splicing factors of the SR protein family play a...
Di Marco, Sergio, Mazroui, Rachid, Dallaire, Patrice, Chittur, Sridar, Tenenbaum, Scott A., Radzioch, Danuta, ...
Muscle wasting (cachexia) is a consequence of chronic diseases, such as cancer, and is associated with degradation of muscle proteins such as MyoD. The cytokines tumor necrosis factor alpha and gamma...
HuR binding to cytoplasmic mRNA is perturbed by heat shock
Gallouzi, Imed-Eddine, Brennan, Christopher M., Stenberg, Myrna G., Swanson, Maurice S., Eversole, Ashley, Maizels, Nancy, ...
AU-rich elements (AREs) located in the 3′ untranslated region target the mRNAs encoding many protooncoproteins, cytokines, and lymphokines for rapid degradation. HuR, a ubiquitously expressed...
Tourrière, Hélène, Gallouzi, Imed-eddine, Chebli, Karim, Capony, Jean Paul, Mouaikel, John, Van Der Geer, Peter, ...
Mitogen activation of mRNA decay pathways likely involves specific endoribonucleases, such as G3BP, a phosphorylation-dependent endoribonuclease that associates with RasGAP in dividing but not...
Gallouzi, Imed-eddine, Parker, Fabienne, Chebli, Karim, Maurier, Florence, Labourier, Emmanuel, Barlat, Isabelle, ...
A potential p120 GTPase-activating protein (RasGAP) effector, G3BP (RasGAP Src homology 3 [SH3] binding protein), was previously identified based on its ability to bind the SH3 domain of RasGAP. Here...
Labourier, Emmanuel, Bourbon, Henri-Marc, Gallouzi, Imed-eddine, Fostier, Maggy, Allemand, Eric, Tazi, Jamal
Specific recognition of splice sites within metazoan mRNA precursors (pre-mRNAs) is a potential stage for gene regulation by alternative splicing. Splicing factors of the SR protein family play a...
Di Marco, Sergio, Mazroui, Rachid, Dallaire, Patrice, Chittur, Sridar, Tenenbaum, Scott A., Radzioch, Danuta, ...
Muscle wasting (cachexia) is a consequence of chronic diseases, such as cancer, and is associated with degradation of muscle proteins such as MyoD. The cytokines tumor necrosis factor alpha and gamma...
Inhibition of the Ubiquitin-Proteasome System Induces Stress Granule Formation
Mazroui, Rachid, Di Marco, Sergio, Kaufman, Randal J., Gallouzi, Imed-Eddine
The inhibition of the ubiquitin-dependent proteasome system (UPS) via specific drugs is one type of approach used to combat cancer. Although it has been suggested that UPS inhibition prevents the...
Involvement of Transportin 2–mediated HuR Import in Muscle Cell Differentiation
Van Der Giessen, Kate, Gallouzi, Imed-Eddine
Muscle fiber formation requires the sequential expression of myogenic regulatory factors (MRFs) such as MyoD and myogenin. The messenger RNAs encoding these two proteins are regulated...
Dormoy-Raclet, Virginie, Ménard, Isabelle, Clair, Eveline, Kurban, Ghada, Mazroui, Rachid, Di Marco, Sergio, ...
A high expression level of the β-actin protein is required for important biological mechanisms, such as maintaining cell shape, growth, and motility. Although the elevated cellular level of the...
Protein Ligands to Hur Modulate Its Interaction with Target Mrnas in Vivo
Brennan, Christopher M., Gallouzi, Imed-Eddine, Steitz, Joan A.
AU-rich elements (AREs) present in the 3′ untranslated regions of many protooncogene, cytokine, and lymphokine messages target them for rapid degradation. HuR, a ubiquitously expressed member of...
Caspase-mediated cleavage of HuR in the cytoplasm contributes to pp32/PHAP-I regulation of apoptosis
Mazroui, Rachid, Di Marco, Sergio, Clair, Eveline, Von Roretz, Christopher, Tenenbaum, Scott A., Keene, Jack D., ...
The RNA-binding protein HuR affects cell fate by regulating the stability and/or the translation of messenger RNAs that encode cell stress response proteins. In this study, we delineate a novel...
Decoding ARE-mediated decay: is microRNA part of the equation?
Von Roretz, Christopher, Gallouzi, Imed-Eddine
Messenger ribonucleic acids (mRNAs) containing adenine/uridine-rich elements (AREs) in their 3′ untranslated region are particularly labile, allowing for the regulation of expression for growth...