Hedgehog signaling maintains a tumor stem cell compartment in multiple myeloma
Peacock, Craig D., Wang, Qiuju, Gesell, Gregory S., Corcoran-Schwartz, Ian M., Jones, Evan, Kim, Jynho, ...
The cancer stem cell hypothesis suggests that malignant growth depends on a subset of tumor cells with stem cell-like properties of self-renewal. Because hedgehog (Hh) signaling regulates progenitor...
Cooperation between the Hic1 and Ptch1 tumor suppressors in medulloblastoma
Briggs, Kimberly J., Corcoran-Schwartz, Ian M., Zhang, Wei, Harcke, Thomas, Devereux, Wendy L., Baylin, Stephen B., ...
Medulloblastoma is an embryonal tumor thought to arise from the granule cell precursors (GCPs) of the cerebellum. PATCHED (PTCH), an inhibitor of Hedgehog signaling, is the best-characterized tumor...