Sal, Lena S., Aachmann, Finn L., Kim, Hwa-Young, Gladyshev, Vadim N., Dikiy, Alexander
Isotopically labeled, 15N and 15N/13C forms of recombinant methionine-R-sulfoxide reductase 1 (MsrB1, SelR) from Mus musculus were produced, in which catalytic selenocysteine was replaced with...
Selenium and methionine sulfoxide reduction (2006)
Kim, Hwa-Young, Gladyshev, Vadim N.
Methionine residues in proteins can be readily oxidized to a diastereomeric mixture of methionine sulfoxides by reactive oxygen species. In most organisms, methionine sulfoxides are reversibly and...
Kim, Hwa-Young, Gladyshev, Vadim
Background: Methionine sulfoxide reduction is an important protein repair pathway that protects against oxidative stress, controls protein function and has a role in regulation of aging. There are...
Kim, Hwa-Young, Gladyshev, Vadim N
Abstract Background Methionine sulfoxide reduction is an important protein repair pathway that protects against oxidative stress, controls protein function and has a role in regulation of aging....
Kim, Hwa-Young, Gladyshev, Vadim
Selenocysteine (Sec) is found in active sites of several oxidoreductases in which this residue is essential for catalytic activity. However, many selenoproteins have fully functional orthologs,...
Hwa-Young Kim, Vadim N. Gladyshev
Altering cysteine-containing residues in a family of oxidoreductases reveals the role of selenocysteine in influencing the catalytic mechanism.
Hwa-Young Kim, Vadim N. Gladyshev
Selenocysteine (Sec) is found in active sites of several oxidoreductases in which this residue is essential for catalytic activity. However, many selenoproteins have fully functional orthologs,...
Kim, Hwa-Young, Gladyshev, Vadim
Methionine residues in proteins are susceptible to oxidation by reactive oxygen species, but can be repaired via reduction of the resulting methionine sulfoxides by methionine-S-sulfoxide reductase...
Molecular Characterization of Cycloinulooligosaccharide Fructanotransferase from Bacillus macerans
Kim, Hwa-Young, Choi, Yong-Jin
Cycloinulooligosaccharide fructanotransferase (CFTase) converts inulin into cyclooligosaccharides of β-(2→1)-linked d-fructofuranose by catalyzing an intramolecular transfructosylation reaction....
Huai, Qing, Kim, Hwa-Young, Liu, Yudong, Zhao, Yingdong, Mondragon, Angelo, Liu, Jun O., ...
Calcineurin, a Ca2+/calmodulin-dependent protein phosphatase, is the common target for two immunophilin–immunosuppressant complexes, cyclophilin A–cyclosporin A (CyPA-CsA) and FKBP–FK506. How...
Methionine Sulfoxide Reduction in Mammals: Characterization of Methionine-R-Sulfoxide Reductases
Kim, Hwa-Young, Gladyshev, Vadim N.
Methionine residues in proteins are susceptible to oxidation by reactive oxygen species, but can be repaired via reduction of the resulting methionine sulfoxides by methionine-S-sulfoxide reductase...
Koc, Ahmet, Gasch, Audrey P., Rutherford, Julian C., Kim, Hwa-Young, Gladyshev, Vadim N.
Aging is thought to be caused by the accumulation of damage, primarily from oxidative modifications of cellular components by reactive oxygen species (ROS). Here we used yeast methionine sulfoxide...
Kim, Hwa-Young, Gladyshev, Vadim N
Selenocysteine (Sec) is found in active sites of several oxidoreductases in which this residue is essential for catalytic activity. However, many selenoproteins have fully functional orthologs,...
Molecular Characterization of Cycloinulooligosaccharide Fructanotransferase from Bacillus macerans
Kim, Hwa-Young, Choi, Yong-Jin
Cycloinulooligosaccharide fructanotransferase (CFTase) converts inulin into cyclooligosaccharides of β-(2→1)-linked d-fructofuranose by catalyzing an intramolecular transfructosylation reaction....
Huai, Qing, Kim, Hwa-Young, Liu, Yudong, Zhao, Yingdong, Mondragon, Angelo, Liu, Jun O., ...
Calcineurin, a Ca2+/calmodulin-dependent protein phosphatase, is the common target for two immunophilin–immunosuppressant complexes, cyclophilin A–cyclosporin A (CyPA-CsA) and FKBP–FK506. How...
Methionine Sulfoxide Reduction in Mammals: Characterization of Methionine-R-Sulfoxide Reductases
Kim, Hwa-Young, Gladyshev, Vadim N.
Methionine residues in proteins are susceptible to oxidation by reactive oxygen species, but can be repaired via reduction of the resulting methionine sulfoxides by methionine-S-sulfoxide reductase...
Koc, Ahmet, Gasch, Audrey P., Rutherford, Julian C., Kim, Hwa-Young, Gladyshev, Vadim N.
Aging is thought to be caused by the accumulation of damage, primarily from oxidative modifications of cellular components by reactive oxygen species (ROS). Here we used yeast methionine sulfoxide...
Kim, Hwa-Young, Gladyshev, Vadim N
Selenocysteine (Sec) is found in active sites of several oxidoreductases in which this residue is essential for catalytic activity. However, many selenoproteins have fully functional orthologs,...