Very Important Pool (VIP) genes – an application for microarray-based molecular signatures (2008)
Su, Zhenqiang, Hong, Huixiao, Fang, Hong, Shi, Leming, Perkins, Roger, Tong, Weida
Abstract Background Advances in DNA microarray technology portend that molecular signatures from which microarray will eventually be used in clinical environments and personalized medicine....
Hong, Huixiao, Su, Zhenqiang, Ge, Weigong, Shi, Leming, Perkins, Roger, Fang, Hong, ...
Abstract Background Genome-wide association studies (GWAS) aim to identify genetic variants (usually single nucleotide polymorphisms [SNPs]) across the entire human genome that are associated with...
Shi, Leming, Jones, Wendell D, Jensen, Roderick V, Harris, Stephen C, Perkins, Roger G, Goodsaid, Federico M, ...
Abstract Background Reproducibility is a fundamental requirement in scientific experiments. Some recent publications have claimed that microarrays are unreliable because lists of differentially...
The Reproducibility of Lists of Differentially Expressed Genes in Microarray Studies (2007)
Leming D. Shi, Wendell D. Jones, Roderick V. Jensen, Stephen C. Harris, Roger G. Perkins, Federico M. Goodsaid, ...
Reproducibility is a fundamental requirement in scientific experiments and clinical contexts. Recent publications raise concerns about the reliability of microarray technology because of the apparent...
The Reproducibility of Lists of Differentially Expressed Genes in Microarray Studies (2007)
Leming Shi, Wendell D. Jones, Roderick V. Jensen, Stephen C. Harris, Roger G. Perkins, Federico M. Goodsaid, ...
Reproducibility is a fundamental requirement in scientific experiments and clinical contexts. Recent publications raise concerns about the reliability of microarray technology because of the apparent...
Microarray scanner calibration curves: characteristics and implications (2005)
Shi, Leming, Tong, Weida, Su, Zhenqiang, Han, Tao, Han, Jing, Puri, Raj K, ...
Abstract Background Microarray-based measurement of mRNA abundance assumes a linear relationship between the fluorescence intensity and the dye concentration. In reality, however, the calibration...
Shi, Leming, Tong, Weida, Fang, Hong, Scherf, Uwe, Han, Jing, Puri, Raj K, ...
Abstract Background The acceptance of microarray technology in regulatory decision-making is being challenged by the existence of various platforms and data analysis methods. A recent report (E....
Xie, Qian, Ratnasinghe, Luke D, Hong, Huixiao, Perkins, Roger, Tang, Ze-Zhong, Hu, Nan, ...
Abstract Background Systematic evaluation and study of single nucleotide polymorphisms (SNPs) made possible by high throughput genotyping technologies and bioinformatics promises to provide...
Hong, Huixiao, Dragan, Yvonne, Epstein, Joshua, Teitel, Candee, Chen, Bangzheng, Xie, Qian, ...
Abstract Background Proteomic profiling of complex biological mixtures by the ProteinChip technology of surface-enhanced laser desorption/ionization time-of-flight (SELDI-TOF) mass spectrometry (MS)...
Identification of a nucleotide binding site in HIV-1 integrase
Drake, Richard R., Neamati, Nouri, Hong, Huixiao, Pilon, Andre A., Sunthankar, Prasanna, Hume, Steven D., ...
HIV-1 integrase is essential for viral replication and can be inhibited by antiviral nucleotides. Photoaffinity labeling with the 3′-azido-3′-deoxythymidine (AZT) analog...
Hong, Huixiao, Tong, Weida, Fang, Hong, Shi, Leming, Xie, Qian, Wu, Jie, ...
A number of environmental chemicals, by mimicking natural hormones, can disrupt endocrine function in experimental animals, wildlife, and humans. These chemicals, called "endocrine-disrupting...
Tong, Weida, Cao, Xiaoxi, Harris, Stephen, Sun, Hongmei, Fang, Hong, Fuscoe, James, ...
The mapping of the human genome and the determination of corresponding gene functions, pathways, and biological mechanisms are driving the emergence of the new research fields of toxicogenomics and...
Tong, Weida, Xie, Qian, Hong, Huixiao, Fang, Hong, Shi, Leming, Perkins, Roger, ...
Class prediction using “omics” data is playing an increasing role in toxicogenomics, diagnosis/prognosis, and risk assessment. These data are usually noisy and represented by relatively few...
Tong, Weida, Xie, Qian, Hong, Huixiao, Shi, Leming, Fang, Hong, Perkins, Roger
Quantitative structure–activity relationship (QSAR) methods have been widely applied in drug discovery, lead optimization, toxicity prediction, and regulatory decisions. Despite major advances in...
Microarray scanner calibration curves: characteristics and implications
Shi, Leming, Tong, Weida, Su, Zhenqiang, Han, Tao, Han, Jing, Puri, Raj K, ...
Identification of a nucleotide binding site in HIV-1 integrase
Drake, Richard R., Neamati, Nouri, Hong, Huixiao, Pilon, Andre A., Sunthankar, Prasanna, Hume, Steven D., ...
HIV-1 integrase is essential for viral replication and can be inhibited by antiviral nucleotides. Photoaffinity labeling with the 3′-azido-3′-deoxythymidine (AZT) analog...
Hong, Huixiao, Tong, Weida, Fang, Hong, Shi, Leming, Xie, Qian, Wu, Jie, ...
A number of environmental chemicals, by mimicking natural hormones, can disrupt endocrine function in experimental animals, wildlife, and humans. These chemicals, called "endocrine-disrupting...
Tong, Weida, Cao, Xiaoxi, Harris, Stephen, Sun, Hongmei, Fang, Hong, Fuscoe, James, ...
The mapping of the human genome and the determination of corresponding gene functions, pathways, and biological mechanisms are driving the emergence of the new research fields of toxicogenomics and...
Tong, Weida, Xie, Qian, Hong, Huixiao, Fang, Hong, Shi, Leming, Perkins, Roger, ...
Class prediction using “omics” data is playing an increasing role in toxicogenomics, diagnosis/prognosis, and risk assessment. These data are usually noisy and represented by relatively few...
Tong, Weida, Xie, Qian, Hong, Huixiao, Shi, Leming, Fang, Hong, Perkins, Roger
Quantitative structure–activity relationship (QSAR) methods have been widely applied in drug discovery, lead optimization, toxicity prediction, and regulatory decisions. Despite major advances in...
Microarray scanner calibration curves: characteristics and implications
Shi, Leming, Tong, Weida, Su, Zhenqiang, Han, Tao, Han, Jing, Puri, Raj K, ...
Very Important Pool (VIP) genes – an application for microarray-based molecular signatures
Su, Zhenqiang, Hong, Huixiao, Fang, Hong, Shi, Leming, Perkins, Roger, Tong, Weida