Hui Wang

Measuring microRNAs: Comparisons of microarray and quantitative PCR measurements, and of different total RNA prep methods (2008)

Ach, Robert A, Wang, Hui, Curry, Bo

Abstract Background Determining the expression levels of microRNAs (miRNAs) is of great interest to researchers in many areas of biology, given the significant roles these molecules play in cellular...

Self-organized periodicity of protein clusters in growing bacteria (2008)

Wang, Hui, Wingreen, Ned S., Mukhopadhyay, Ranjan

Chemotaxis receptors in E. coli form clusters at the cell poles and also laterally along the cell body, and this clustering plays an important role in signal transduction. Recently, experiments using...

Network Quotients: Structural Skeletons of Complex Systems (2008)

Xiao, Yanghua, MacArthur, Ben D., Wang, Hui, Xiong, Momiao, Wang, Wei

A defining feature of many large empirical networks is their intrinsic complexity. However, many networks also contain a large degree of structural repetition. An immediate question then arises: can...

Markov models for inferring Copy Number Variations from genotype data (2008)

Hui Wang, Jan Veldink, Roel Opoff, Sabatti, Chiara

We develop an algorithm to analyze data from Illumina genotyping arrays for the detection of copy number variations in a single individual or in a random sample of individuals. We use a Hidden Markov...

ULTRA HIGH RESOLUTION AND CONTRAST SENSITIVE OPTICAL COHERENCE TOMOGRAPHY (2008)

Wang, Hui

In this thesis, I first demonstrate three novel broad band light sources at above 1 µm for ultra-high resolution optical coherence tomography (OCT) based on multiple SLED combination and...

catena-Poly[[tetraaqua(μ-4,4′-bipyridine-κ2N:N′)zinc(II)] fumarate tetrahydrate] (2008)

Yong Tian, Ya-Pan Wu, Dong-Sheng Li, Hui Wang, Ji-Wu Wang

In the title compound, {[Zn(C10H8N2)(H2O)4](C4H2O4)·4H2O}n, the ZnII atom is coordinated by two N atoms from two μ-4,4′-bipyridine ligands and four water molecules in a distorted...

The relationship between genetic polymorphism of GSTM1 and the outcome of chemotherapy in Chinese patients with primary lung cancer (2008)

Weiying LI, Yanfei GU, Baitang LAI, Hui WANG

Background and objective GSTM1 takes part in the metabolism of environmental pollutants such as benzopyrene other polycyclic aromatic hydrocarbons and anticancer drugs and so on. The study aims to...

Effects of p53 gene on drug resistance in human lung cancer cell lines (2008)

Hong TAO, Yunzhong ZHU, Hui WANG, Baitang LAI, Xiuping ZHAN, Yue WANG, ...

Background and Objective Drug resistance of lung cancer cells is one of main factors which affect the outcome of chemotherapy. It has been reported that abnormal p53 gene is well assosiated with...

The Relationship between EGFR Mutations and Response and Prognosis of Tyrosine Kinase Inhibitors in Advanced Non-small-cell Lung Cancer (2008)

Xinyong ZHANG, Liyan XU, Hui WANG, Yunzhong ZHU, Zhe LIU, Wentao YUE, ...

Background and objectives It has been proven that epigermal growth factor receptor (EGFR) signal pathway plaied an important role in the oncogenesis and development of non-small cell lung cancer...

The Roles of a LIM Domain Protein, Hic-5/ARA55, in TGF-β Signaling in Prostate Cancer Cells (2008)

Wang, Hui

Findings from our laboratory as well as from others support that transforming growth factor beta (TGF-β) functions as a critical tumor suppressor of the prostate. During the progression of a variety...

Dynamic importance sampling for queueing networks (2007)

Dupuis, Paul, Sezer, Ali Devin, Wang, Hui

Importance sampling is a technique that is commonly used to speed up Monte Carlo simulation of rare events. However, little is known regarding the design of efficient importance sampling algorithms...

Symmetry based Structure Entropy of Complex Networks (2007)

Xiao, Yanghua, Wu, Wentao, Wang, Hui, Xiong, Momiao, Wang, Wei

Precisely quantifying the heterogeneity or disorder of a network system is very important and desired in studies of behavior and function of the network system. Although many degree-based entropies...

Emergence of Symmetry in Complex Networks (2007)

Xiao, Yanghua, Xiong, Momiao, Wang, Wei, Wang, Hui

Many real networks have been found to have a rich degree of symmetry, which is a very important structural property of complex network, yet has been rarely studied so far. And where does symmetry...

Homogeneous and heterogeneous nucleation of Lennard-Jones liquids (2007)

Wang, Hui, Gould, Harvey, Klein, W.

The homogeneous and heterogeneous nucleation of a Lennard-Jones liquid is investigated using the umbrella sampling method. The free energy cost of forming a nucleating droplet is determined as a...

Discovery of tissue-specific exons using comprehensive human exon microarrays (2007)

Clark, Tyson A, Schweitzer, Anthony C, Chen, Tina X, Staples, Michelle K, Lu, Gang, Wang, Hui, ...

Abstract Background Higher eukaryotes express a diverse population of messenger RNAs generated by alternative splicing. Large-scale methods for monitoring gene expression must adapt in order to...

Approaching equilibrium and the distribution of clusters (2007)

Wang, Hui, Barros, Kipton, Gould, Harvey, Klein, W.

We investigate the approach to stable and metastable equilibrium in Ising models using a cluster representation. The distribution of nucleation times is determined using the Metropolis algorithm and...

A mobile element-based evolutionary history of guenons (tribe Cercopithecini) (2007)

Xing, Jinchuan, Wang, Hui, Zhang, Yuhua, Ray, David A, Tosi, Anthony J, Disotell, Todd R, ...

Abstract Background Guenons (tribe Cercopithecini) are a species-rich group of primates that have attracted considerable attention from both primatologists and evolutionary biologists. The complex...

Paths to Modernity: China and India (2007)

Wang, Hui, Subrahmanyam, Sanjay

Wang Hui, editor of Dushu (Beijing), talked about the different historical narratives of China. He argued that the emergence of the modern nation state began in the Song Dynasty and thus the process...

Subsolutions of an Isaacs Equation and Efficient Schemes for Importance Sampling: Examples and Numerics (2007)

Dupuis, Paul, Wang, Hui

It has been established that importance sampling algorithms for estimating rare-event probabilities are intimately connected with two-person zero-sum differential games and the associated Isaacs...

Dynamic Importance Sampling for Queueing Networks (2007)

Dupuis, Paul, Sezer, Ali D., Wang, Hui

Importance sampling is a technique that is commonly used to speed up Monte Carlo simulation of rare events. However, little is known regarding the design of efficient importance sampling algorithms...

Importance Sampling for Sums of Random Variables With Regularly Varying Tails (2007)

Dupuis, Paul, Leder, Kevin, Wang, Hui

Importance sampling is a variance reduction technique for efficient estimation of rare-event probabilities by Monte Carlo. For random variables with heavy tails there is little consensus on how to...

Subsolutions of an Isaacs Equation and Efficient Schemes for Importance Sampling: Convergence Analysis (2007)

Dupuis, Paul, Wang, Hui

Previous papers by authors establish the connection between importance sampling algorithms for estimating rare-event probabilities, two-person zero-sum differential games, and the associated Isaacs...

Tuning DCDHF (dicyanomethylenedihydrofuran) Fluorophores and their applications in biological systems (2007)

Wang, Hui

The application of single molecule spectroscopy in living cells is one of the most active fields in this area. DCDHF (dicyanomethylenedihydrofuran) fluorophores have been successfully imaged at the...

DESIGN, SYNTHESIS, AND SUPRAMOLECULAR SURFACE CHEMISTRY OF BI- AND TRIDENTATE SURFACE ANCHORS FOR NANOSCIENCE AND NANOBIOTECHNOLOGY (2007)

Wang, Hui

This dissertation describes the design, synthesis, and supramolecular surface chemistry of bi- and tri-dentate surface anchors for nanoscience and nanobiotechnology. Molecular electronic device...

Numerical Simulation of Dental Resurfacing of a Feldspar Porcelain with Coarse Diamond Burs (2007)

Song, Xiao-Fei, Yin, Ling, Han, Yi-Gang, Wang, Hui, Li, Jia

Dental bioceramics are more and more attractive to both dentists and patients due to their unique biocompatibility and esthetics; they can be fabricated efficiently using chair-side CAD/CAM dental...

SVA Elements: Hominid Specific Retrotransposons (2006)

Wang, Hui

SVA is a composite repetitive element named after its main components, SINE, VNTR and Alu. There are ~3000 SVA elements in the human genome. A genomic distribution analysis indicates that SVA...

SVA Elements: Hominid Specific Retrotransposons (2006)

Wang, Hui

SVA is a composite repetitive element named after its main components, SINE, VNTR and Alu. There are ~3000 SVA elements in the human genome. A genomic distribution analysis indicates that SVA...

COPI Activity Coupled with Fatty Acid Biosynthesis Is Required for Viral Replication (2006)

Sara Cherry, Amit Kunte, Hui Wang, Carolyn Coyne, Robert B. Rawson, Norbert Perrimon

During infection by diverse viral families, RNA replication occurs on the surface of virally induced cytoplasmic membranes of cellular origin. How this process is regulated, and which cellular...

Overexpression of ribosomal protein L15 is associated with cell proliferation in gastric cancer (2006)

Wang, Hui, Zhao, Li-Na, Li, Kai-Zong, Ling, Rui, Li, Xiao-Jun, Wang, Ling

Abstract Background Ribosomal proteins are the components of ribosome, which also exhibit various secondary functions in DNA repair, apoptosis, drug resistance and proliferation. In our previous...

Genetic and Genomic Analysis of a Fat Mass Trait with Complex Inheritance Reveals Marked Sex Specificity (2006)

Susanna Wang, Nadir Yehya, Eric E. Schadt, Hui Wang, Thomas A. Drake, Aldons J. Lusis

The integration of expression profiling with linkage analysis has increasingly been used to identify genes underlying complex phenotypes. The effects of gender on the regulation of many physiological...

Unusual Intron Conservation near Tissue-Regulated Exons Found by Splicing Microarrays (2006)

Charles W. Sugnet, Karpagam Srinivasan, Tyson A. Clark, Georgeann O'Brien, Melissa S. Cline, Hui Wang, ...

Alternative splicing contributes to both gene regulation and protein diversity. To discover broad relationships between regulation of alternative splicing and sequence conservation, we applied a...

SVA elements hominid specific retrotransposons / (2006)

Wang, Hui.

Thesis (Ph. D.)--Louisiana State University, Baton Rouge, 2006.

Novel roles of Akt and mTOR in suppressing TGF-beta/ALK5-mediated Smad3 activation. (2006)

Song, Kyung, Wang, Hui, Krebs, Tracy L, Danielpour, David

Insulin-like growth factor-I inhibits transforming growth factor-beta (TGF-beta) signaling by blocking activation of Smad3 (S3), via a phosphatidylinositol 3-kinase (PI3K)/Akt-dependent pathway. Here...

Current views concerning the influences of murine hepatic endothelial adhesive and cytotoxic properties on interactions between metastatic tumor cells and the liver (2005)

Wang, Hui, Qiu, Hongming, Qi, Ke, Orr, F William

Abstract Substantial recent experimental evidence has demonstrated the existence of reciprocal interactions between the microvascular bed of a specific organ and intravascular metastatic tumor cells...

Unusual Intron Conservation Near Tissue-regulated Exons Found by Splicing Microarrays (2005)

Charles W Sugnet, Karpagam Srinivasan, Tyson A Clark, Georgeann O'Brien, Melissa S Cline, Hui Wang, ...

Alternative splicing contributes to both gene regulation and protein diversity. To discover broad relationships between regulation of alternative splicing and sequence conservation, we applied a...

On the convergence from discrete to continuous time in an optimal stopping problem (2005)

Dupuis, Paul, Wang, Hui

We consider the problem of optimal stopping for a one-dimensional diffusion process. Two classes of admissible stopping times are considered. The first class consists of all nonanticipating stopping...

On the convergence from discrete to continuous time in an optimal stopping problem (2005)

Dupuis, Paul, Wang, Hui

We consider the problem of optimal stopping for a one-dimensional diffusion process. Two classes of admissible stopping times are considered. The first class consists of all nonanticipating stopping...

Inferring genomic loss and location of tumor suppressor genes from high density genotypes (2005)

Wang, Hui, Lee, Yohan, Nelson, Stanley, Sabatti, Chiara

Novel technologies, such as the 10k Affymetrix genotyping array, allow scoring of genetic polymorphisms at a very high density across the genome. This allows researchers to conduct traditional...

Dynamic importance sampling for uniformly recurrent markov chains (2005)

Dupuis, Paul, Wang, Hui

Importance sampling is a variance reduction technique for efficient estimation of rare-event probabilities by Monte Carlo. In standard importance sampling schemes, the system is simulated using an a...

Dynamic importance sampling for uniformly recurrent Markov chains (2005)

Dupuis, Paul, Wang, Hui

Importance sampling is a variance reduction technique for efficient estimation of rare-event probabilities by Monte Carlo. In standard importance sampling schemes, the system is simulated using an a...

A new approach of detecting influential markers for complex phenotypes with genotype data (2005)

Wang, Hui

With the increase in the use of genomewide studies, large-scale genome scans have become common tools in search of susceptibility genes for complex human disorders. The statistical methods, developed...

Essays on two financial market anomalies / (2005)

Wang, Hui.

Thesis (Ph. D.)--Yale University, 2005.

Recombinant probiotics for treatment and prevention of enterotoxigenic Escherichia coli diarrhea (2005)

Paton, Adrienne W., Jennings, Michael P., Morona, Renato, Wang, Hui, Focareta, Antonio, Roddam, Louise F., ...

Background & Aims: We have developed a therapeutic strategy for gastrointestinal infections that is based on molecular mimicry of host receptors for bacterial toxins on the surface of harmless gut...

Pricing Path-Dependent Options with Jump Risk via Laplace Transforms (2005)

Kou, Steven, Petrella, Giovanni, Wang, Hui

We present analytical solutions for two-dimensional Laplace transforms of barrier option prices, as well as an approximation based on Laplace transforms for the prices of finite-time horizon American...

Classification Based on Contextual Probability (2004)

Hui Wang, Sally Mcclean

Data Mining is often concerned with large and complex datasets. However the data space may be sparse and contain regions that are poorly covered.

Data Reduction and Noise Filtering for Predicting (2004)

Gongde Guo, Hui Wang, David Bell

In this paper we introduce a modification of the real discrete Fourier transform and its inverse transform to filter noise and perform reduction on the data whilst preserving the trend of global...

A Density Based Approach to Classification (2004)

Hui Wang, David Bell, Ivo D Untsch

This paper presents a novel method for classification, which is density based and makes use of the models built by the lattice machine (LM) [5, 7]. Density is a natural concept to use in clustering...

Asymmetric Neighbourhood Selection and Support (2004)

Gongde Guo, Hui Wang, David Bell

Thek-Nearest-Neighbours (kNN) is a simple but effective method for classification. The success of kNN in classification depends on the selection of a "good value" for k. To reduce the bias of k and...

Time Series Data Analysis and Pre-process on (2004)

Gongde Guo, Hui Wang, David Bell

In this paper we introduce a novel classification algorithm called MCC (Minimal Cover Classification), which works well for numerical data and categorical data. Given a new data tuple, it provides...