Hugues Lelouard

Brucella Control of Dendritic Cell Maturation Is Dependent on the TIR-Containing Protein Btp1 (2008)

Suzana P. Salcedo, María Ines Marchesini, Hugues Lelouard, Emilie Fugier, Gilles Jolly, Stephanie Balor, ...

Brucella is an intracellular pathogen able to persist for long periods of time within the host and establish a chronic disease. We show that soon after Brucella inoculation in intestinal loops,...

Mucin-Related Epitopes Distinguish M Cells and Enterocytes in Rabbit Appendix and Peyer’s Patches

Lelouard, Hugues, Reggio, Hubert, Mangeat, Paul, Neutra, Marian, Montcourrier, Philippe

The biochemical composition of the apical membranes of epithelial M cells overlying the gut-associated lymphoid tissues (GALT) is still largely unknown. We have prepared monoclonal antibodies (MAbs)...

Glycocalyx on Rabbit Intestinal M Cells Displays Carbohydrate Epitopes from Muc2

Lelouard, Hugues, Reggio, Hubert, Roy, Christian, Sahuquet, Alain, Mangeat, Paul, Montcourrier, Philippe

It is essential to investigate the apical surface properties of both M cells and dome enterocytes to understand the mechanisms involved in the binding of pathogens to M cells. In rabbit appendix...

Human cathepsin S, but not cathepsin L, degrades efficiently MHC class II-associated invariant chain in nonprofessional APCs

Bania, Jacek, Gatti, Evelina, Lelouard, Hugues, David, Alexandre, Cappello, Fanny, Weber, Ekkehard, ...

MHC class II-restricted antigen presentation plays a central role in the immune response against exogenous antigens. The association of invariant (Ii) chain with MHC class II dimers is required for...

Mucin-Related Epitopes Distinguish M Cells and Enterocytes in Rabbit Appendix and Peyer’s Patches

Lelouard, Hugues, Reggio, Hubert, Mangeat, Paul, Neutra, Marian, Montcourrier, Philippe

The biochemical composition of the apical membranes of epithelial M cells overlying the gut-associated lymphoid tissues (GALT) is still largely unknown. We have prepared monoclonal antibodies (MAbs)...

Glycocalyx on Rabbit Intestinal M Cells Displays Carbohydrate Epitopes from Muc2

Lelouard, Hugues, Reggio, Hubert, Roy, Christian, Sahuquet, Alain, Mangeat, Paul, Montcourrier, Philippe

It is essential to investigate the apical surface properties of both M cells and dome enterocytes to understand the mechanisms involved in the binding of pathogens to M cells. In rabbit appendix...

Human cathepsin S, but not cathepsin L, degrades efficiently MHC class II-associated invariant chain in nonprofessional APCs

Bania, Jacek, Gatti, Evelina, Lelouard, Hugues, David, Alexandre, Cappello, Fanny, Weber, Ekkehard, ...

MHC class II-restricted antigen presentation plays a central role in the immune response against exogenous antigens. The association of invariant (Ii) chain with MHC class II dimers is required for...

Progressively impaired proteasomal capacity during terminal plasma cell differentiation

Cenci, Simone, Mezghrani, Alexandre, Cascio, Paolo, Bianchi, Giada, Cerruti, Fulvia, Fra, Anna, ...

After few days of intense immunoglobulin (Ig) secretion, most plasma cells undergo apoptosis, thus ending the humoral immune response. We asked whether intrinsic factors link plasma cell lifespan to...

Dendritic cell aggresome-like induced structures are dedicated areas for ubiquitination and storage of newly synthesized defective proteins

Lelouard, Hugues, Ferrand, Vincent, Marguet, Didier, Bania, Jacek, Camosseto, Voahirana, David, Alexandre, ...

In response to inflammatory stimulation, dendritic cells (DCs) have a remarkable pattern of differentiation (maturation) that exhibits specific mechanisms to control antigen processing and...

Brucella Control of Dendritic Cell Maturation Is Dependent on the TIR-Containing Protein Btp1

Salcedo, Suzana P, Marchesini, María Ines, Lelouard, Hugues, Fugier, Emilie, Jolly, Gilles, Balor, Stephanie, ...

Brucella is an intracellular pathogen able to persist for long periods of time within the host and establish a chronic disease. We show that soon after Brucella inoculation in intestinal loops,...

Regulation of translation is required for dendritic cell function and survival during activation

Lelouard, Hugues, Schmidt, Enrico K., Camosseto, Voahirana, Clavarino, Giovanna, Ceppi, Maurizio, Hsu, Hsiang-Ting, ...

In response to inflammatory stimulation, dendritic cells (DCs) have a remarkable pattern of differentiation (maturation) that exhibits specific mechanisms to control antigen processing and...