Hua-Poo Su

Essential Role for the C-Terminal Noncatalytic Region of SHIP in FcγRIIB1-Mediated Inhibitory Signaling

Aman, M. Javad, Walk, Scott F., March, Michael E., Su, Hua-Poo, Carver, D. Jeannean, Ravichandran, Kodimangalam S.

The inositol phosphatase SHIP binds to the FcγRIIB1 receptor and plays a critical role in FcγRIIB1-mediated inhibition of B-cell proliferation and immunoglobulin synthesis. The molecular details of...

Human Immunodeficiency Virus Type 1 Pathogenesis in SCID-hu Mice Correlates with Syncytium-Inducing Phenotype and Viral Replication

Camerini, David, Su, Hua-Poo, Gamez-Torre, Graciela, Johnson, Michael L., Zack, Jerome A., Chen, Irvin S. Y.

Human immunodeficiency virus type 1 (HIV-1) patient isolates and molecular clones were used to analyze the determinants responsible for human CD4+ thymocyte depletion in SCID-hu mice....

The 1.51-Å structure of the poxvirus L1 protein, a target of potent neutralizing antibodies

Su, Hua-Poo, Garman, Scott C., Allison, Timothy J., Fogg, Christiana, Moss, Bernard, Garboczi, David N.

Although eradicated from nature more than two decades ago, the threat of smallpox has reemerged because of concerns over its use as a biological weapon. We present the structure of the poxvirus L1...

The Structure of G4, the Poxvirus Disulfide Oxidoreductase Essential for Virus Maturation and Infectivity

Su, Hua-Poo, Lin, David Yin-wei, Garboczi, David N.

The possibility of the release of smallpox virus into a predominantly nonimmunized population highlights the importance of understanding poxvirus biology. Poxviruses encode a conserved pathway that...

Essential Role for the C-Terminal Noncatalytic Region of SHIP in FcγRIIB1-Mediated Inhibitory Signaling

Aman, M. Javad, Walk, Scott F., March, Michael E., Su, Hua-Poo, Carver, D. Jeannean, Ravichandran, Kodimangalam S.

The inositol phosphatase SHIP binds to the FcγRIIB1 receptor and plays a critical role in FcγRIIB1-mediated inhibition of B-cell proliferation and immunoglobulin synthesis. The molecular details of...

Human Immunodeficiency Virus Type 1 Pathogenesis in SCID-hu Mice Correlates with Syncytium-Inducing Phenotype and Viral Replication

Camerini, David, Su, Hua-Poo, Gamez-Torre, Graciela, Johnson, Michael L., Zack, Jerome A., Chen, Irvin S. Y.

Human immunodeficiency virus type 1 (HIV-1) patient isolates and molecular clones were used to analyze the determinants responsible for human CD4+ thymocyte depletion in SCID-hu mice....

The 1.51-Å structure of the poxvirus L1 protein, a target of potent neutralizing antibodies

Su, Hua-Poo, Garman, Scott C., Allison, Timothy J., Fogg, Christiana, Moss, Bernard, Garboczi, David N.

Although eradicated from nature more than two decades ago, the threat of smallpox has reemerged because of concerns over its use as a biological weapon. We present the structure of the poxvirus L1...

The Structure of G4, the Poxvirus Disulfide Oxidoreductase Essential for Virus Maturation and Infectivity

Su, Hua-Poo, Lin, David Yin-wei, Garboczi, David N.

The possibility of the release of smallpox virus into a predominantly nonimmunized population highlights the importance of understanding poxvirus biology. Poxviruses encode a conserved pathway that...

Redundancy and Plasticity of Neutralizing Antibody Responses Are Cornerstone Attributes of the Human Immune Response to the Smallpox Vaccine▿ †

McCausland, Megan M., Su, Hua-Poo, Singh, Kavita, Hoffmann, Julia, Davies, D. Huw, ...

The smallpox vaccine is widely considered the gold standard for human vaccines, yet the key antibody targets in humans remain unclear. We endeavored to identify a stereotypic, dominant, mature virion...

The PD-1/PD-L1 complex resembles the antigen-binding Fv domains of antibodies and T cell receptors

Lin, David Yin-wei, Tanaka, Yoshimasa, Iwasaki, Masashi, Gittis, Apostolos G., Su, Hua-Poo, Mikami, Bunzo, ...

Signaling through the programmed death 1 (PD-1) inhibitory receptor upon binding its ligand, PD-L1, suppresses immune responses against autoantigens and tumors and plays an important role in the...

The Cysteine-Rich Interdomain Region from the Highly Variable Plasmodium falciparum Erythrocyte Membrane Protein-1 Exhibits a Conserved Structure

Klein, Michael M., Gittis, Apostolos G., Su, Hua-Poo, Makobongo, Morris O., Moore, Jaime M., Singh, Sanjay, ...

Plasmodium falciparum malaria parasites, living in red blood cells, express proteins of the erythrocyte membrane protein-1 (PfEMP1) family on the red blood cell surface. The binding of PfEMP1...