Isolation of neuronal chromatin from brain tissue (2008)
Jiang, Yan, Matevossian, Anouch, Huang, Hsien-Sung, Straubhaar, Juerg, Akbarian, Schahram
Abstract Background DNA-protein interactions in mature brain are increasingly recognized as key regulators for behavioral plasticity and neuronal dysfunction in chronic neuropsychiatric disease....
Huang, Hsien-Sung, Matevossian, Anouch, Whittle, Catheryne, Kim, Se Young, Schumacher, Armin, Baker, Stephen P., ...
Alterations in GABAergic mRNA expression play a key role for prefrontal dysfunction in schizophrenia and other neurodevelopmental disease. Here, we show that histone H3-lysine 4 methylation, a...
Akbarian, Schahram, Huang, Hsien-Sung
The 67 and 65 kDa isoforms of glutamic acid decarboxylase, the key enzymes for GABA biosynthesis, are expressed at altered levels in postmortem brain of subjects diagnosed with schizophrenia and...
Chromatin immunoprecipitation in postmortem brain (2006)
Huang, Hsien-Sung, Matevossian, Anouch, Jiang, Yan, Akbarian, Schahram
Methylation and other covalent modifications of nucleosome core histones are key regulators of chromatin structure and function, including epigenetic control of gene expression. For the human brain,...
GAD1 mRNA Expression and DNA Methylation in Prefrontal Cortex of Subjects with Schizophrenia
Huang, Hsien-Sung, Akbarian, Schahram
Dysfunction of prefrontal cortex in schizophrenia includes changes in GABAergic mRNAs, including decreased expression of GAD1, encoding the 67 kDa glutamate decarboxylase (GAD67) GABA synthesis...