Rubins, Kathleen H, Hensley, Lisa E, Wahl-Jensen, Victoria, Daddario DiCaprio, Kathleen M, Young, Howard A, Reed, Douglas S, ...
Abstract Background Infection with Ebola virus (EBOV) causes a fulminant and often fatal hemorrhagic fever. In order to improve our understanding of EBOV pathogenesis and EBOV-host interactions, we...
Pathogenesis of Ebola Hemorrhagic Fever in Cynomolgus Macaques (1998)
Geisbert, Thomas W., Hensley, Lisa E., Larsen, Tom, Young, Howard A., Reed, Douglas S.
Ebola virus (EBOV) infection causes a severe and fatal hemorrhagic disease that in many ways appears to be similar in humans and nonhuman primates; however, little is known about the development of...
Krakauer, Teresa, Chen, Xin, Howard, O. M., Young, Howard A.
Proinflammatory cytokines mediate the toxic effects of superantigenic staphylococcal exotoxins (SE) and bacterial lipopolysaccharide (LPS). Triptolide, an oxygenated diterpene derived from a...
Interleukin-1 polymorphisms associated with increased risk of gastric cancer
El Omar, Emad M., Carrington, Mary, Chow, Wong-Ho, McColl, Kenneth E. L., Bream, Jay H., Young, Howard A., ...
Helicobacter pylori infection is associated with a variety of clinical outcomes including gastric cancer and duodenal ulcer disease. The reasons for this variation are not clear, but the gastric...
Pathogen-specific loss of host resistance in mice lacking the IFN-γ-inducible gene IGTP
Taylor, Gregory A., Collazo, Carmen M., Yap, George S., Nguyen, Khuong, Gregorio, Theresa A., Taylor, Lynn S., ...
Interferon-γ (IFN-γ) is critical for defense against pathogens, but the molecules that mediate its antimicrobial responses are largely unknown. IGTP is the prototype for a family of...
Mikovits, Judy A., Young, Howard A., Vertino, Paula, Issa, Jean-Pierre J., Pitha, Paula M., Turcoski-Corrales, Susan, ...
The immune response to pathogens is regulated by a delicate balance of cytokines. The dysregulation of cytokine gene expression, including interleukin-12, tumor necrosis factor alpha, and gamma...
Hodge, Deborah L., Martinez, Alfredo, Julias, John G., Taylor, Lynn S., Young, Howard A.
Posttranscriptional control of gamma interferon (IFN-γ) gene expression has not been extensively studied and is poorly understood. Our work describes a posttranscriptional mechanism that modulates...
Bacillus anthracis lethal toxin induces TNF-α–independent hypoxia-mediated toxicity in mice
Moayeri, Mahtab, Haines, Diana, Young, Howard A., Leppla, Stephen H.
Bacillus anthracis lethal toxin (LT) is the major virulence factor of anthrax and reproduces most of the laboratory manifestations of the disease in animals. We studied LT toxicity in BALB/cJ and...
Mazzoni, Alessandra, Young, Howard A., Spitzer, Jessica H., Visintin, Alberto, Segal, David M.
Atopic diseases such as allergy and asthma are characterized by increases in Th2 cells and serum IgE antibodies. The binding of allergens to IgE on mast cells triggers the release of several...
Interleukin 2 plays a central role in Th2 differentiation
Cote-Sierra, Javier, Foucras, Gilles, Guo, Liying, Chiodetti, Lynda, Young, Howard A., Hu-Li, Jane, ...
Differentiation of naïve CD4 T cells into T helper (Th) 2 cells requires signaling through the T cell receptor and an appropriate cytokine environment. IL-4 is critical for such Th2 differentiation....
Distinct Regions of the Interleukin-7 Receptor Regulate Different Bcl2 Family Members
Jiang, Qiong, Li, Wen Qing, Hofmeister, Robert R., Young, Howard A., Hodge, David R., Keller, Jonathan R., ...
The antiapoptotic function of the interleukin-7 (IL-7) receptor is related to regulation of three members of the Bcl2 family: synthesis of Bcl2, phosphorylation of Bad, and cytosolic retention of...
Moayeri, Mahtab, Martinez, Nathaniel W., Wiggins, Jason, Young, Howard A., Leppla, Stephen H.
Bacillus anthracis lethal toxin (LT) produces symptoms of anthrax in mice and induces rapid lysis of macrophages (Mφ) derived from certain inbred strains. We used nine inbred strains and two...
COACTIVATORS AND COREPRESSORS OF NF-KB IN IkB ALPHA GENE PROMOTER
Gao, Zhanguo, Chiao, Paul, Zhang, Xia, Zhang, Xiaohong, Lazar, Mitchell, Seto, Edward, ...
In this study, we investigated recruitment of coactivators (SRC-1, SRC-2 and SRC-3) and corepressors (HDAC1, HDAC2, HDAC3, SMRT and NCoR) to the IkBα gene promoter after NF-kB activation by TNF-α....
The Scaffold Protein Cybr Is Required for Cytokine-Modulated Trafficking of Leukocytes In Vivo
Coppola, Vincenzo, Barrick, Colleen A., Bobisse, Sara, Rodriguez-Galan, Maria Cecilia, Pivetta, Michela, Reynolds, Della, ...
Trafficking and cell adhesion are key properties of cells of the immune system. However, the molecular pathways that control these cellular behaviors are still poorly understood. Cybr is a scaffold...
Pathogen-specific loss of host resistance in mice lacking the IFN-γ-inducible gene IGTP
Taylor, Gregory A., Collazo, Carmen M., Yap, George S., Nguyen, Khuong, Gregorio, Theresa A., Taylor, Lynn S., ...
Interferon-γ (IFN-γ) is critical for defense against pathogens, but the molecules that mediate its antimicrobial responses are largely unknown. IGTP is the prototype for a family of...
Mikovits, Judy A., Young, Howard A., Vertino, Paula, Issa, Jean-Pierre J., Pitha, Paula M., Turcoski-Corrales, Susan, ...
The immune response to pathogens is regulated by a delicate balance of cytokines. The dysregulation of cytokine gene expression, including interleukin-12, tumor necrosis factor alpha, and gamma...
Hodge, Deborah L., Martinez, Alfredo, Julias, John G., Taylor, Lynn S., Young, Howard A.
Posttranscriptional control of gamma interferon (IFN-γ) gene expression has not been extensively studied and is poorly understood. Our work describes a posttranscriptional mechanism that modulates...
Bacillus anthracis lethal toxin induces TNF-α–independent hypoxia-mediated toxicity in mice
Moayeri, Mahtab, Haines, Diana, Young, Howard A., Leppla, Stephen H.
Bacillus anthracis lethal toxin (LT) is the major virulence factor of anthrax and reproduces most of the laboratory manifestations of the disease in animals. We studied LT toxicity in BALB/cJ and...
Mazzoni, Alessandra, Young, Howard A., Spitzer, Jessica H., Visintin, Alberto, Segal, David M.
Atopic diseases such as allergy and asthma are characterized by increases in Th2 cells and serum IgE antibodies. The binding of allergens to IgE on mast cells triggers the release of several...
Interleukin 2 plays a central role in Th2 differentiation
Cote-Sierra, Javier, Foucras, Gilles, Guo, Liying, Chiodetti, Lynda, Young, Howard A., Hu-Li, Jane, ...
Differentiation of naïve CD4 T cells into T helper (Th) 2 cells requires signaling through the T cell receptor and an appropriate cytokine environment. IL-4 is critical for such Th2 differentiation....
Distinct Regions of the Interleukin-7 Receptor Regulate Different Bcl2 Family Members
Jiang, Qiong, Li, Wen Qing, Hofmeister, Robert R., Young, Howard A., Hodge, David R., Keller, Jonathan R., ...
The antiapoptotic function of the interleukin-7 (IL-7) receptor is related to regulation of three members of the Bcl2 family: synthesis of Bcl2, phosphorylation of Bad, and cytosolic retention of...
Moayeri, Mahtab, Martinez, Nathaniel W., Wiggins, Jason, Young, Howard A., Leppla, Stephen H.
Bacillus anthracis lethal toxin (LT) produces symptoms of anthrax in mice and induces rapid lysis of macrophages (Mφ) derived from certain inbred strains. We used nine inbred strains and two...
The Scaffold Protein Cybr Is Required for Cytokine-Modulated Trafficking of Leukocytes In Vivo
Coppola, Vincenzo, Barrick, Colleen A., Bobisse, Sara, Rodriguez-Galan, Maria Cecilia, Pivetta, Michela, Reynolds, Della, ...
Trafficking and cell adhesion are key properties of cells of the immune system. However, the molecular pathways that control these cellular behaviors are still poorly understood. Cybr is a scaffold...
Interleukin-1 polymorphisms associated with increased risk of gastric cancer
El Omar, Emad M., Carrington, Mary, Chow, Wong-Ho, McColl, Kenneth E. L., Bream, Jay H., Young, Howard A., ...
Helicobacter pylori infection is associated with a variety of clinical outcomes including gastric cancer and duodenal ulcer disease. The reasons for this variation are not clear, but the gastric...
Salcedo, Rosalba, Wasserman, Ken, Young, Howard A., Grimm, Michael C., Howard, O. M. Zack, Anver, Miriam R., ...
The contribution of chemokines toward angiogenesis is currently a focus of intensive investigation. Certain members of the CXC chemokine family can induce bovine capillary endothelial cell migration...
Geisbert, Thomas W., Hensley, Lisa E., Larsen, Tom, Young, Howard A., Reed, Douglas S., Geisbert, Joan B., ...
Ebola virus (EBOV) infection causes a severe and fatal hemorrhagic disease that in many ways appears to be similar in humans and nonhuman primates; however, little is known about the development of...
Geisbert, Thomas W., Young, Howard A., Jahrling, Peter B., Davis, Kelly J., Larsen, Tom, Kagan, Elliott, ...
Ebola virus (EBOV) infection causes a severe and often fatal hemorrhagic disease in humans and nonhuman primates. Whether infection of endothelial cells is central to the pathogenesis of EBOV...
Regulation of ITAM-positive receptors: role of IL-12 and IL-18
Ortaldo, John R., Winkler-Pickett, Robin, Wigginton, Jon, Horner, Meagan, Bere, Earl W., Mason, Anna T., ...
Our previous studies have identified mechanisms by which cytokine production, blocked by Ly49G2 receptor cross-linking, can be overridden. In this study we analyzed the regulation of other...
Hematopoiesis and Thymic Apoptosis Are Not Affected by the Loss of Cdk2▿
Berthet, Cyril, Rodriguez-Galan, Maria Cecilia, Hodge, Deborah L., Gooya, John, Pascal, Véronique, Young, Howard A., ...
Cell cycle regulation is essential for proper homeostasis of hematopoietic cells. Cdk2 is a major regulator of S phase entry, is activated by mitogenic cytokines, and has been suggested to be...
The chemotherapeutic agent DMXAA potently and specifically activates the TBK1–IRF-3 signaling axis
Roberts, Zachary J., Goutagny, Nadege, Perera, Pin-Yu, Kato, Hiroki, Kumar, Himanshu, Kawai, Taro, ...
Vascular disrupting agents (VDAs) represent a novel approach to the treatment of cancer, resulting in the collapse of tumor vasculature and tumor death. 5,6-dimethylxanthenone-4-acetic acid (DMXAA)...
Cytokine-driven cell cycling is mediated through Cdc25A
Khaled, Annette R., Bulavin, Dmitry V., Kittipatarin, Christina, Li, Wen Qing, Alvarez, Michelle, Kim, Kyungjae, ...
Lymphocytes are the central mediators of the immune response, requiring cytokines for survival and proliferation. Survival signaling targets the Bcl-2 family of apoptotic mediators, however, the...
Role of Natural Killer Cells in Innate Protection against Lethal Ebola Virus Infection
Warfield, Kelly L., Perkins, Jeremy G., Swenson, Dana L., Deal, Emily M., Bosio, Catharine M., Aman, M. Javad, ...
Ebola virus is a highly lethal human pathogen and is rapidly driving many wild primate populations toward extinction. Several lines of evidence suggest that innate, nonspecific host factors are...
Saitoh, Shin-ichiroh, Odom, Sandra, Gomez, Gregorio, Sommers, Connie L., Young, Howard A., Rivera, Juan, ...
The linker for activation of T cells (LAT) is an adaptor protein critical for FcɛRI-mediated mast cell activation. LAT is a substrate of the tyrosine kinases activated after TCR and FcɛRI...
Rubins, Kathleen H, Hensley, Lisa E, Wahl-Jensen, Victoria, Daddario DiCaprio, Kathleen M, Young, Howard A, Reed, Douglas S, ...
Primate blood cells were analysed for changes in global gene expression patterns at several time points following infection with Ebola virus, providing insights into potential mechanisms of viral...