Maojun Yang, Bing Li, Chyong-Jy Liu, Diana R. Tomchick, Mischa Machius, Josep Rizo, ...
In response to misaligned sister chromatids during mitosis, the spindle checkpoint protein Mad2 inhibits the anaphase-promoting complex or cyclosome (APC/C) through binding to its mitotic activator...
Hongjun WANG, Qiong CHEN, Hongtao YU
Background and Objective Many studies have proven that telomerase plays an important role during the occurrence and development of lung cancer, which has been an important target in gene therapy. The...
Jun-Jie Yin, Qingsu Xia, Shu-Hui Cherng, I-Wah Tang, Peter P. Fu, Ge Lin, ...
Polycyclic aromatic hydrocarbons (PAHs) are widespread genotoxic environmental pollutants and potentially pose a health risk to humans. Although the biological and toxicological activities, including...
Responses of Antioxidant Enzymes in Catfish Exposed to Liquid Crystals from E-Waste (2008)
Ran An, Yadong Li, Xiaojun Niu, Hongtao Yu
Liquid crystals (LCs) are typically elongated organic molecules with a non-uniform distribution of electrical charges leading to a dipole. LCs are widely used in displays of computers and other...
Running on a treadmill: dynamic inhibition of APC/C by the spindle checkpoint (2007)
Díaz-Martínez, Laura A, Yu, Hongtao
Abstract During mitosis, the genome duplicated during S-phase is synchronously and accurately segregated to the two daughter cells. The spindle checkpoint prevents premature sister-chromatid...
Charity N. Mosley, Lei Wang, Stephanie Gilley, Shuguang Wang, Hongtao Yu
2-Phenylbenzimidazole (PBI) is an ingredient found in sunscreen agents. PBI can absorb the UV portion of the solar light and undergo a series of light-induced reactions to cause adverse effects in...
Hui-Chan Chen, Qingsu Xia, Shu-Hui Cherng, Shoujun Chen, Ching-Cheng Lai, Hongtao Yu, ...
Polycyclic aromatic hydrocarbons (PAHs) are widespread genotoxic environmental pollutants. We have recently demonstrated that photoirradiation of PAHs leads to cytotoxicity, DNA damage, and induction...
Kang, Jungseog, Gocke, Christian B, Yu, Hongtao
Abstract Background Sumoylation has emerged as an important posttranslational regulatory mechanism for transcription factors and cofactors. Sumoylation of many transcription factors represses their...
Qingsu Xia, Jun J. Yin, Wayne G. Wamer, Shu-Hui Cherng, Mary D. Boudreau, Paul C. Howard, ...
We have previously reported that photoirradiation of retinyl palmitate (RP), a storage and ester form of vitamin A (retinol), with UVA light resulted in the formation of photodecomposition products,...
Hongtao Yu, Qingsu Xia, Jian Yan, Diogenes Herreno-Saenz, Yuh-Shen Wu, I-Wah Tang, ...
Polycyclic aromatic hydrocarbons (PAHs) are a class of genotoxic environmental contaminants. We have long been interested in determining the mechanisms by which PAHs induce genotoxicity. Although the...
Hongtao Yu, Jian Yan, Yuguo Jiao, Peter P. Fu
DMBA, 7,12-dimethylbenz[a]anthracene, is a widely studied polycyclic aromatic hydrocarbon that has long been recognized as a probable human carcinogen. It has been found that DMBA is phototoxic in...
Inorganic ions, coenzymes, amino acids, and saccharides could co-exist with toxic environmental chemicals, such as polycyclic aromatic hydrocarbons (PAHs), in the cell. The presence of these...
Photodecomposition and Phototoxicity of Natural Retinoids (2005)
William H. Tolleson, Shui-Hui Cherng, Qingsu Xia, Mary Boudreau, Jun Jie Yin, Wayne G. Wamer, ...
Sunlight is a known human carcinogen. Many cosmetics contain retinoid-based compounds, such as retinyl palmitate (RP), either to protect the skin or to stimulate skin responses that will correct skin...
Barbara Graham-Evans, Kenneth Ndebele, John K. Jenkins, Robert McMurray, Jian Yan, ...
In Eastern cultures, such as India, it is traditionally recommended that women but not men cover their heads while working in the scorching sun. The purpose of this pilot study was to determine...
Barbara Graham-Evans, Hongtao Yu, Paul B. Tchounwou
Arsenical keratosis and skin cancer are among the most common health effects associated with acute and chronic exposures to arsenic. This study examines the acute and chronic dose-responses of...
Influence of Humic Acid on 1-Aminopyrene Ecotoxicity During Solar Photolysis Process (2002)
Ana L. Balarezo, Veleka N. Jones, Hongtao Yu, Huey-Min Hwang
Abstract: 1-Aminopyrene (1-AP), a polycyclic aromatic hydrocarbons (PAH) compound, is a major metabolite during biotransformation of 1-nitropyrene by microflora in natural environment and in the guts...
n/a
Shiming Dong, Shuguang Wang, Gernerique Stewart, Huey-Min Hwang, Hongtao Yu
Abstract: Polycyclic aromatic hydrocarbons (PAHs) are a class of carcinogenic compounds that are both naturally and artificially produced. Many PAHs are pro-carcinogens that require metabolic...
Yuh-Shen Wu, Guor-Cheng Fang, Joanna Moody, Peter P. Fu, Huey-Min Hwang, ...
Abstract: Stereoselective metabolism of dibenzo[a,l]pyrene (DB[a,l]P), 2-chlorodibenzo[a,l]pyrene (2-Cl-DB[a,l]P) and 10-chlorodibenzo[a,l]pyrene (10-Cl-DB[a,l]P) by rat liver microsomes was studied...
Structural analyses of signaling proteins /--by Hongtao Yu. (1995)
Thesis (Ph. D.)--Harvard University, 1995.
Tang, Zhanyun, Li, Bing, Bharadwaj, Rajnish, Zhu, Haizhen, Özkan, Engin, Hakala, Kevin, ...
In mitosis, the anaphase-promoting complex (APC) regulates the onset of sister-chromatid separation and exit from mitosis by mediating the ubiquitination and degradation of the securin protein and...
He, Qun, Cheng, Ping, Yang, Yuhong, He, Qiyang, Yu, Hongtao, Liu, Yi
Phosphorylation of the Neurospora circadian clock protein FREQUENCY (FRQ) regulates its degradation and the proper function of the clock. The mechanism by which FRQ undergoes degradation has not been...
Araki, Marito, Wharton, Robin P., Tang, Zhanyun, Yu, Hongtao, Asano, Maki
The initiation of DNA synthesis is thought to occur at sites bound by a heteromeric origin recognition complex (ORC). Previously, we have shown that in Drosophila, the level of the large subunit,...
Fang, Guowei, Yu, Hongtao, Kirschner, Marc W.
The spindle assembly checkpoint mechanism delays anaphase initiation until all chromosomes are aligned at the metaphase plate. Activation of the anaphase-promoting complex (APC) by binding of CDC20...
Conformation-specific binding of p31comet antagonizes the function of Mad2 in the spindle checkpoint
Xia, Guohong, Luo, Xuelian, Habu, Toshiyuki, Rizo, Josep, Matsumoto, Tomohiro, Yu, Hongtao
The spindle checkpoint ensures accurate chromosome segregation by delaying anaphase in response to misaligned sister chromatids during mitosis. Upon checkpoint activation, Mad2 binds directly to...
A requirement for breast-cancer-associated gene 1 (BRCA1) in the spindle checkpoint
Wang, Rui-Hong, Yu, Hongtao, Deng, Chu-Xia
BRCA1-associated breast cancer exhibits significantly higher levels of chromosomal abnormalities than sporadic breast cancers. However, the molecular mechanisms regarding the roles of BRCA1 in...
Human Bub1 protects centromeric sister-chromatid cohesion through Shugoshin during mitosis
Tang, Zhanyun, Sun, Yuxiao, Harley, Sara E., Zou, Hui, Yu, Hongtao
Sister chromatids in mammalian cells remain attached mostly at their centromeres at metaphase because of the loss of cohesion along chromosome arms in prophase. Here, we report that Bub1 retains...
Liu, Baoying, Hong, Sohee, Tang, Zhanyun, Yu, Hongtao, Giam, Chou-Zen
Expression of the human T lymphotropic virus type I (HTLV-I) transactivator/oncoprotein, Tax, leads to faulty mitosis as reflected by chromosome aneuploidy, cytokinesis failure, and formation of...
Human MMS21/NSE2 Is a SUMO Ligase Required for DNA Repair†
Potts, Patrick Ryan, Yu, Hongtao
DNA repair is required for the genomic stability and well-being of an organism. In yeasts, a multisubunit complex consisting of SMC5, SMC6, MMS21/NSE2, and other non-SMC proteins is required for DNA...
A novel motif governs APC-dependent degradation of Drosophila ORC1 in vivo
Araki, Marito, Yu, Hongtao, Asano, Maki
Regulated degradation plays a key role in setting the level of many factors that govern cell cycle progression. In Drosophila, the largest subunit of the origin recognition complex protein 1 (ORC1)...
Özkan, Engin, Yu, Hongtao, Deisenhofer, Johann
Ubiquitin-conjugating enzymes (E2s) collaborate with the ubiquitin-activating enzyme (E1) and ubiquitin ligases (E3s) to attach ubiquitin to target proteins. RING-containing E3s simultaneously bind...
Qi, Wei, Tang, Zhanyun, Yu, Hongtao
Polo-like kinase 1 (Plk1) is required for the generation of the tension-sensing 3F3/2 kinetochore epitope and facilitates kinetochore localization of Mad2 and other spindle checkpoint proteins. Here,...
Tang, Zhanyun, Li, Bing, Bharadwaj, Rajnish, Zhu, Haizhen, Özkan, Engin, Hakala, Kevin, ...
In mitosis, the anaphase-promoting complex (APC) regulates the onset of sister-chromatid separation and exit from mitosis by mediating the ubiquitination and degradation of the securin protein and...
He, Qun, Cheng, Ping, Yang, Yuhong, He, Qiyang, Yu, Hongtao, Liu, Yi
Phosphorylation of the Neurospora circadian clock protein FREQUENCY (FRQ) regulates its degradation and the proper function of the clock. The mechanism by which FRQ undergoes degradation has not been...
Araki, Marito, Wharton, Robin P., Tang, Zhanyun, Yu, Hongtao, Asano, Maki
The initiation of DNA synthesis is thought to occur at sites bound by a heteromeric origin recognition complex (ORC). Previously, we have shown that in Drosophila, the level of the large subunit,...
Fang, Guowei, Yu, Hongtao, Kirschner, Marc W.
The spindle assembly checkpoint mechanism delays anaphase initiation until all chromosomes are aligned at the metaphase plate. Activation of the anaphase-promoting complex (APC) by binding of CDC20...
Conformation-specific binding of p31comet antagonizes the function of Mad2 in the spindle checkpoint
Xia, Guohong, Luo, Xuelian, Habu, Toshiyuki, Rizo, Josep, Matsumoto, Tomohiro, Yu, Hongtao
The spindle checkpoint ensures accurate chromosome segregation by delaying anaphase in response to misaligned sister chromatids during mitosis. Upon checkpoint activation, Mad2 binds directly to...
A requirement for breast-cancer-associated gene 1 (BRCA1) in the spindle checkpoint
Wang, Rui-Hong, Yu, Hongtao, Deng, Chu-Xia
BRCA1-associated breast cancer exhibits significantly higher levels of chromosomal abnormalities than sporadic breast cancers. However, the molecular mechanisms regarding the roles of BRCA1 in...
Human Bub1 protects centromeric sister-chromatid cohesion through Shugoshin during mitosis
Tang, Zhanyun, Sun, Yuxiao, Harley, Sara E., Zou, Hui, Yu, Hongtao
Sister chromatids in mammalian cells remain attached mostly at their centromeres at metaphase because of the loss of cohesion along chromosome arms in prophase. Here, we report that Bub1 retains...
Liu, Baoying, Hong, Sohee, Tang, Zhanyun, Yu, Hongtao, Giam, Chou-Zen
Expression of the human T lymphotropic virus type I (HTLV-I) transactivator/oncoprotein, Tax, leads to faulty mitosis as reflected by chromosome aneuploidy, cytokinesis failure, and formation of...
Human MMS21/NSE2 Is a SUMO Ligase Required for DNA Repair†
Potts, Patrick Ryan, Yu, Hongtao
DNA repair is required for the genomic stability and well-being of an organism. In yeasts, a multisubunit complex consisting of SMC5, SMC6, MMS21/NSE2, and other non-SMC proteins is required for DNA...
A novel motif governs APC-dependent degradation of Drosophila ORC1 in vivo
Araki, Marito, Yu, Hongtao, Asano, Maki
Regulated degradation plays a key role in setting the level of many factors that govern cell cycle progression. In Drosophila, the largest subunit of the origin recognition complex protein 1 (ORC1)...
Özkan, Engin, Yu, Hongtao, Deisenhofer, Johann
Ubiquitin-conjugating enzymes (E2s) collaborate with the ubiquitin-activating enzyme (E1) and ubiquitin ligases (E3s) to attach ubiquitin to target proteins. RING-containing E3s simultaneously bind...
Qi, Wei, Tang, Zhanyun, Yu, Hongtao
Polo-like kinase 1 (Plk1) is required for the generation of the tension-sensing 3F3/2 kinetochore epitope and facilitates kinetochore localization of Mad2 and other spindle checkpoint proteins. Here,...
Potts, Patrick Ryan, Porteus, Matthew H, Yu, Hongtao
The structural maintenance of chromosomes (SMC) family of proteins has been implicated in the repair of DNA double-strand breaks (DSBs) by homologous recombination (HR). The SMC1/3 cohesin complex is...
Running on a treadmill: dynamic inhibition of APC/C by the spindle checkpoint
Díaz-Martínez, Laura A, Yu, Hongtao
During mitosis, the genome duplicated during S-phase is synchronously and accurately segregated to the two daughter cells. The spindle checkpoint prevents premature sister-chromatid separation and...
The inheritance of a normal assortment of chromosomes during each cell division relies on a cell-cycle surveillance system called the mitotic spindle checkpoint. The existence of sister chromatids...
Yang, Maojun, Li, Bing, Liu, Chyong-Jy, Tomchick, Diana R, Machius, Mischa, Rizo, Josep, ...
In response to misaligned sister chromatids during mitosis, the spindle checkpoint protein Mad2 inhibits the anaphase-promoting complex or cyclosome (APC/C) through binding to its mitotic activator...
Autophosphorylation-dependent activation of human Mps1 is required for the spindle checkpoint
Kang, Jungseog, Chen, Yue, Zhao, Yingming, Yu, Hongtao
The spindle checkpoint ensures the accuracy of chromosome segregation during mitosis. The protein serine/threonine kinase, Mps1, is a critical component of the spindle checkpoint in human cells and...
ZNF198 Stabilizes the LSD1–CoREST–HDAC1 Complex on Chromatin through Its MYM-Type Zinc Fingers
Gocke, Christian B., Yu, Hongtao
Histone modifications in chromatin regulate gene expression. A transcriptional co-repressor complex containing LSD1–CoREST–HDAC1 (termed LCH hereafter for simplicity) represses transcription by...