The brain H3-receptor as a novel therapeutic target for vigilance and sleep-wake disorders. (2007)
Parmentier, Régis, Anaclet, Christelle, Guhennec, Christian, Brousseau, Emmanuel, Bricout, Denis, Giboulot, Thierry, ...
Brain histaminergic neurons play a prominent role in arousal and maintenance of wakefulness (W). H(3)-receptors control the activity of histaminergic neurons through presynaptic autoinhibition. The...
The brain H3-receptor as a novel therapeutic target for vigilance and sleep-wake disorders. (2007)
Parmentier, Régis, Anaclet, Christelle, Guhennec, Christian, Brousseau, Emmanuel, Bricout, Denis, Giboulot, Thierry, ...
Brain histaminergic neurons play a prominent role in arousal and maintenance of wakefulness (W). H(3)-receptors control the activity of histaminergic neurons through presynaptic autoinhibition. The...
Suzuki-Ishigaki, Satsuki, Numayama-Tsuruta, Keiko, Kuramasu, Atsuo, Sakurai, Eiko, Makabe, Yoko, Shimura, Sanae, ...
To investigate the regulation of mouse l-histidine decarboxylase (HDC) gene expression, we isolated genomic DNA clones encoding HDC. Structural analysis revealed that the mouse HDC gene was composed...
Suzuki-Ishigaki, Satsuki, Numayama-Tsuruta, Keiko, Kuramasu, Atsuo, Sakurai, Eiko, Makabe, Yoko, Shimura, Sanae, ...
To investigate the regulation of mouse l-histidine decarboxylase (HDC) gene expression, we isolated genomic DNA clones encoding HDC. Structural analysis revealed that the mouse HDC gene was composed...
Enhancement of neutrophil infiltration in histidine decarboxylase-deficient mice
Hirasawa, Noriyasu, Ohtsu, Hiroshi, Watanabe, Takehiko, Ohuchi, Kazuo
The roles of histamine in the anaphylactic increase in vascular permeability and leucocyte infiltration were analysed in an air pouch-type allergic inflammation model in histidine...
Schneider, Elke, Machavoine, François, Pléau, Jean-Marie, Bertron, Anne-France, Thurmond, Robin L., Ohtsu, Hiroshi, ...
In this study, we identify the bidirectional organic cation transporter 3 (OCT3/Slc22a3) as the molecule responsible for histamine uptake by murine basophils. We demonstrate that OCT3 participates in...
Ghosh, Ajoy Kumar, Hirasawa, Noriyasu, Ohtsu, Hiroshi, Watanabe, Takehiko, Ohuchi, Kazuo
We have analyzed the role of histamine in the angiogenesis of the granulation tissue in histidine decarboxylase–deficient (HDC−/−) mice, mast cell–deficient mice (WBB6F1-W/WV), and their...
Beghdadi, Walid, Porcherie, Adeline, Schneider, Bradley S., Dubayle, David, Peronet, Roger, Huerre, Michel, ...
From the inoculation of Plasmodium sporozoites via Anopheles mosquito bites to the development of blood-stage parasites, a hallmark of the host response is an inflammatory reaction characterized by...