Ohtsuka, Masato, Inoko, Hidetoshi, Kulski, Jerzy K, Yoshimura, Shinichi
Abstract Background The mouse has more than 30 Major histocompatibility complex ( Mhc ) class Ib genes, most of which exist in the H2 region of chromosome 17 in distinct gene clusters. Although...
Polymorphism of IFN-gamma gene and Vogt-Koyanagi-Harada disease. (2007)
Horie, Yukihiro, Kitaichi, Nobuyoshi, Takemoto, Yuko, Namba, Kenichi, Yoshida, Kazuhiko, Hirose, Shigeto, ...
PURPOSE: Interferon-gamma (IFN-gamma) is a key cytokine in inflammatory disorders. Elevated aqueous and serum levels of IFN-gamma levels have been reported to be elevated in patients with...
Hosomichi, Kazuyoshi, Shiina, Takashi, Suzuki, Shingo, Tanaka, Masayuki, Shimizu, Sayoko, Iwamoto, Shigehisa, ...
Abstract Background The quail and chicken major histocompatibility complex ( Mhc ) genomic regions have a similar overall organization but differ markedly in that the quail has an expanded number of...
Tyrosinase gene family and Vogt-Koyanagi-Harada disease in Japanese patients. (2006)
Horie, Yukihiro, Takemoto, Yuko, Miyazaki, Akiko, Namba, Kenichi, Kase, Satoru, Yoshida, Kazuhiko, ...
PURPOSE: The aim of the present study was to examine the genetic background of Vogt-Koyanagi-Harada (VKH) disease in a Japanese population by analyzing the tyrosinase gene family (TYR, TYRP1, and...
Luo, Meizhong, Kim, HyeRan, Kudrna, Dave, Sisneros, Nicholas B, Lee, So-Jeong, Mueller, Christopher, ...
Abstract Background Sharks are members of the taxonomic class Chondrichthyes, the oldest living jawed vertebrates. Genomic studies of this group, in comparison to representative species in other...
Integrative Annotation of 21,037 Human Genes Validated by Full-Length cDNA Clones (2004)
Tadashi Imanishi, Takeshi Itoh, Yutaka Suzuki, Claire O'Donovan, Satoshi Fukuchi, Kanako O. Koyanagi, ...
An international team has systematically validated and annotated just over 21,000 human genes using full-length cDNA, thereby providing a valuable new resource for the human genetics community.
Integrative Annotation of 21,037 Human Genes Validated by Full-Length cDNA Clones (2004)
Tadashi Imanishi, Takeshi Itoh, Yutaka Suzuki, Claire O'Donovan, Satoshi Fukuchi, Kanako O. Koyanagi, ...
The human genome sequence defines our inherent biological potential; the realization of the biology encoded therein requires knowledge of the function of each gene. Currently, our knowledge in this...
The genomic sequence and comparative analysis of the rat major histocompatibility complex (2004)
Hurt,Peter, Walter,Lutz, Sudbrak,Ralf, Klages,Sven, Mueller,Ines, Shiina,Takashi, ...
We have determined the sequence of a 4-Mb interval on rat chromosome 20p12 that encompasses the rat major histocompatibility complex (MHC). This is the first report of a finished sequence for a...
The genomic sequence and comparative analysis of the rat major histocompatibility complex (2004)
Hurt, Peter, Walter, Lutz, Sudbrak, Ralf, Klages, Sven, Mueller, Ines, Shiina, Takashi, ...
We have determined the sequence of a 4-Mb interval on rat chromosome 20p12 that encompasses the rat major histocompatibility complex (MHC). This is the first report of a finished sequence for a...
Mizuki, Nobuhisa, Ota, Masao, Kimura, Minoru, Ohno, Shigeaki, Ando, Hitoshi, Katsuyama, Yoshihiko, ...
A member of a novel family of the human major histocompatibility complex (MHC) class I genes termed MIC (MHC class I chain-related genes), MICA, has been recently identified near the HLA-B gene on...
Shiina, Takashi, Tamiya, Gen, Oka, Akira, Takishima, Nobusada, Yamagata, Tetsushi, Kikkawa, Eri, ...
The intensely studied MHC has become the paradigm for understanding the architectural evolution of vertebrate multigene families. The 4-Mb human MHC (also known as the HLA complex) encodes genes...
A basolateral sorting motif in the MICA cytoplasmic tail
Suemizu, Hiroshi, Radosavljevic, Mirjana, Kimura, Minoru, Sadahiro, Sotaro, Yoshimura, Shinichi, Bahram, Seiamak, ...
The MHC class I chain-related MICA molecule is a stress-induced, highly polymorphic, epithelia-specific, membrane-bound glycoprotein interacting with the activating NK cell receptor NKG2D and/or...
Anzai, Tatsuya, Shiina, Takashi, Kimura, Natsuki, Yanagiya, Kazuyo, Kohara, Sakae, Shigenari, Atsuko, ...
Despite their high degree of genomic similarity, reminiscent of their relatively recent separation from each other (≈6 million years ago), the molecular basis of traits unique to humans vs. their...
Ohtsuka, Masato, Makino, Satoshi, Yoda, Kinya, Wada, Hironori, Naruse, Kiyoshi, Mitani, Hiroshi, ...
Double anal fin (Da) is a medaka with an autosomal semidominant mutation that causes mirror image duplication of the ventral region concentrating on the caudal region. The chromosomal location of the...
Shiina, Takashi, Ando, Asako, Suto, Yumiko, Kasai, Fumio, Shigenari, Atsuko, Takishima, Nobusada, ...
Human chromosomes 1q21–q25, 6p21.3–22.2, 9q33–q34, and 19p13.1–p13.4 carry clusters of paralogous loci, to date best defined by the flagship 6p MHC region. They have presumably been created...
Kawamura, Kazuyuki, Yamamura, Takashi, Yokoyama, Kazumasa, Chui, De-Hua, Fukui, Yoshinori, Sasazuki, Takehiko, ...
In multiple sclerosis (MS) patients who carry the Class II major histocompatibility (MHC) type HLA-DR2, T cells specific for amino acids 95-116 in the proteolipid protein (PLP) are activated and...
The Genomic Sequence and Comparative Analysis of the Rat Major Histocompatibility Complex
Hurt, Peter, Walter, Lutz, Sudbrak, Ralf, Klages, Sven, Müller, Ines, Shiina, Takashi, ...
We have determined the sequence of a 4-Mb interval on rat chromosome 20p12 that encompasses the rat major histocompatibility complex (MHC). This is the first report of a finished sequence for a...
Integrative Annotation of 21,037 Human Genes Validated by Full-Length cDNA Clones
Imanishi, Tadashi, Itoh, Takeshi, Suzuki, Yutaka, O'Donovan, Claire, Fukuchi, Satoshi, Koyanagi, Kanako O, ...
The human genome sequence defines our inherent biological potential; the realization of the biology encoded therein requires knowledge of the function of each gene. Currently, our knowledge in this...
Ohtsuka, Masato, Horiuchi, Shohei, Kulski, Jerzy K., Kimura, Minoru, Inoko, Hidetoshi
The web software CHOP was developed to visualize the ‘wobbling’ in the third codon position of aligned DNA sequences. The simple features of this tool allow users to easily find regions suspected...
Novel algorithm for automated genotyping of microsatellites
Matsumoto, Toshiko, Yukawa, Wataru, Nozaki, Yasuyuki, Nakashige, Ryo, Shinya, Minori, Makino, Satoshi, ...
Microsatellites or short tandem repeats (STRs) are abundant in the human genome with easily assayed polymorphisms, providing powerful genetic tools for mapping both Mendelian and complex traits....
Genomic evolution of MHC class I region in primates
Fukami-Kobayashi, Kaoru, Shiina, Takashi, Anzai, Tatsuya, Sano, Kazumi, Yamazaki, Masaaki, Inoko, Hidetoshi, ...
To elucidate the origins of the MHC-B-MHC-C pair and the MHC class I chain-related molecule (MIC)A-MICB pair, we sequenced an MHC class I genomic region of humans, chimpanzees, and rhesus monkeys and...
Fine Localization of a Major Disease-Susceptibility Locus for Diffuse Panbronchiolitis
Keicho, Naoto, Ohashi, Jun, Tamiya, Gen, Nakata, Koichiro, Taguchi, Yoshio, Azuma, Arata, ...
Diffuse panbronchiolitis affecting East Asians is strongly associated with the class I human leukocyte antigen (HLA) alleles. Recent observations suggest that a major disease-susceptibility gene may...
Luo, Meizhong, Kim, HyeRan, Kudrna, Dave, Sisneros, Nicholas B, Lee, So-Jeong, Mueller, Christopher, ...
Shiina, Takashi, Ota, Masao, Shimizu, Sayoko, Katsuyama, Yoshihiko, Hashimoto, Nami, Takasu, Miwa, ...
A plausible explanation for many MHC-linked diseases is lacking. Sequencing of the MHC class I region (coding units or full contigs) in several human and nonhuman primate haplotypes allowed an...
Mizuki, Nobuhisa, Ota, Masao, Kimura, Minoru, Ohno, Shigeaki, Ando, Hitoshi, Katsuyama, Yoshihiko, ...
A member of a novel family of the human major histocompatibility complex (MHC) class I genes termed MIC (MHC class I chain-related genes), MICA, has been recently identified near the HLA-B gene on...
Shiina, Takashi, Tamiya, Gen, Oka, Akira, Takishima, Nobusada, Yamagata, Tetsushi, Kikkawa, Eri, ...
The intensely studied MHC has become the paradigm for understanding the architectural evolution of vertebrate multigene families. The 4-Mb human MHC (also known as the HLA complex) encodes genes...
A basolateral sorting motif in the MICA cytoplasmic tail
Suemizu, Hiroshi, Radosavljevic, Mirjana, Kimura, Minoru, Sadahiro, Sotaro, Yoshimura, Shinichi, Bahram, Seiamak, ...
The MHC class I chain-related MICA molecule is a stress-induced, highly polymorphic, epithelia-specific, membrane-bound glycoprotein interacting with the activating NK cell receptor NKG2D and/or...
Anzai, Tatsuya, Shiina, Takashi, Kimura, Natsuki, Yanagiya, Kazuyo, Kohara, Sakae, Shigenari, Atsuko, ...
Despite their high degree of genomic similarity, reminiscent of their relatively recent separation from each other (≈6 million years ago), the molecular basis of traits unique to humans vs. their...
Ohtsuka, Masato, Makino, Satoshi, Yoda, Kinya, Wada, Hironori, Naruse, Kiyoshi, Mitani, Hiroshi, ...
Double anal fin (Da) is a medaka with an autosomal semidominant mutation that causes mirror image duplication of the ventral region concentrating on the caudal region. The chromosomal location of the...
Shiina, Takashi, Ando, Asako, Suto, Yumiko, Kasai, Fumio, Shigenari, Atsuko, Takishima, Nobusada, ...
Human chromosomes 1q21–q25, 6p21.3–22.2, 9q33–q34, and 19p13.1–p13.4 carry clusters of paralogous loci, to date best defined by the flagship 6p MHC region. They have presumably been created...
Kawamura, Kazuyuki, Yamamura, Takashi, Yokoyama, Kazumasa, Chui, De-Hua, Fukui, Yoshinori, Sasazuki, Takehiko, ...
In multiple sclerosis (MS) patients who carry the Class II major histocompatibility (MHC) type HLA-DR2, T cells specific for amino acids 95-116 in the proteolipid protein (PLP) are activated and...
Okamoto, Koichi, Makino, Satoshi, Yoshikawa, Yoko, Takaki, Asumi, Nagatsuka, Yumie, Ota, Masao, ...
Rheumatoid arthritis (RA) is a chronic inflammatory joint disease with a complex etiology in which environmental factors within a genetically susceptible host maneuver the innate and adaptive arms of...
The Genomic Sequence and Comparative Analysis of the Rat Major Histocompatibility Complex
Hurt, Peter, Walter, Lutz, Sudbrak, Ralf, Klages, Sven, Müller, Ines, Shiina, Takashi, ...
We have determined the sequence of a 4-Mb interval on rat chromosome 20p12 that encompasses the rat major histocompatibility complex (MHC). This is the first report of a finished sequence for a...
Integrative Annotation of 21,037 Human Genes Validated by Full-Length cDNA Clones
Imanishi, Tadashi, Itoh, Takeshi, Suzuki, Yutaka, O'Donovan, Claire, Fukuchi, Satoshi, Koyanagi, Kanako O, ...
The human genome sequence defines our inherent biological potential; the realization of the biology encoded therein requires knowledge of the function of each gene. Currently, our knowledge in this...
Ohtsuka, Masato, Horiuchi, Shohei, Kulski, Jerzy K., Kimura, Minoru, Inoko, Hidetoshi
The web software CHOP was developed to visualize the ‘wobbling’ in the third codon position of aligned DNA sequences. The simple features of this tool allow users to easily find regions suspected...
Novel algorithm for automated genotyping of microsatellites
Matsumoto, Toshiko, Yukawa, Wataru, Nozaki, Yasuyuki, Nakashige, Ryo, Shinya, Minori, Makino, Satoshi, ...
Microsatellites or short tandem repeats (STRs) are abundant in the human genome with easily assayed polymorphisms, providing powerful genetic tools for mapping both Mendelian and complex traits....
Genomic evolution of MHC class I region in primates
Fukami-Kobayashi, Kaoru, Shiina, Takashi, Anzai, Tatsuya, Sano, Kazumi, Yamazaki, Masaaki, Inoko, Hidetoshi, ...
To elucidate the origins of the MHC-B-MHC-C pair and the MHC class I chain-related molecule (MIC)A-MICB pair, we sequenced an MHC class I genomic region of humans, chimpanzees, and rhesus monkeys and...
Fine Localization of a Major Disease-Susceptibility Locus for Diffuse Panbronchiolitis
Keicho, Naoto, Ohashi, Jun, Tamiya, Gen, Nakata, Koichiro, Taguchi, Yoshio, Azuma, Arata, ...
Diffuse panbronchiolitis affecting East Asians is strongly associated with the class I human leukocyte antigen (HLA) alleles. Recent observations suggest that a major disease-susceptibility gene may...
Luo, Meizhong, Kim, HyeRan, Kudrna, Dave, Sisneros, Nicholas B, Lee, So-Jeong, Mueller, Christopher, ...
Shiina, Takashi, Ota, Masao, Shimizu, Sayoko, Katsuyama, Yoshihiko, Hashimoto, Nami, Takasu, Miwa, ...
A plausible explanation for many MHC-linked diseases is lacking. Sequencing of the MHC class I region (coding units or full contigs) in several human and nonhuman primate haplotypes allowed an...
Hosomichi, Kazuyoshi, Shiina, Takashi, Suzuki, Shingo, Tanaka, Masayuki, Shimizu, Sayoko, Iwamoto, Shigehisa, ...
Genomewide Association Analysis of Human Narcolepsy and a New Resistance Gene
Kawashima, Minae, Tamiya, Gen, Oka, Akira, Hohjoh, Hirohiko, Juji, Takeo, Ebisawa, Takashi, ...
Human narcolepsy is a hypersomnia that is affected by multiple genetic and environmental factors. One genetic factor strongly associated with narcolepsy is the HLA-DRB1*1501-DQB1*0602 haplotype in...
Uenishi, Hirohide, Hiraiwa, Hideki, Yamamoto, Ryuji, Yasue, Hiroshi, Takagaki, Yohtaroh, Shiina, Takashi, ...
A complete genomic region of 131·2 kb including the swine T-cell receptor α/δ constant region (TRAC/TRDC) and joining segments (TRAJ/TRDJ) was sequenced. The structure of this region was...
Genetic Analysis of Craniofacial Traits in the Medaka
Kimura, Tetsuaki, Shimada, Atsuko, Sakai, Noriyoshi, Mitani, Hiroshi, Naruse, Kiyoshi, Takeda, Hiroyuki, ...
Family and twin studies suggest that a substantial genetic component underlies individual differences in craniofacial morphology. In the current study, we quantified 444 craniofacial traits in 100...
Kimura, Tetsuaki, Kobayashi, Terukazu, Munkhbat, Batmunkh, Oyungerel, Ganjuur, Bilegtsaikhan, Tsolmon, Anar, Damdinsuren, ...
We performed a genome-wide association study with 23,465 microsatellite markers to identify genes related to adult height. Selective genotyping was applied to extremely tall and extremely short...