Bogyo, Matthew, McMaster, John S., Gaczynska, Maria, Tortorella, Domenico, Goldberg, Alfred L., Ploegh, Hidde
The proteasome is a multicatalytic protease complex that plays a key role in diverse cellular functions. The peptide vinyl sulfone, carboxybenzyl-leucyl-leucyl-leucine vinyl sulfone (Z-L3VS)...
Vugmeyster, Yulia, Glas, Rickard, Pérarnau, Béatrice, Lemonnier, François A., Eisen, Herman, Ploegh, Hidde
We obtained mice deficient for major histocompatibility complex (MHC) molecules encoded by the H-2K and H-2D genes. H-2 KbDb −/− mice express no detectable classical MHC class I-region associated...
Tourne, Sylvie, Miyazaki, Toru, Wolf, Paula, Ploegh, Hidde, Benoist, Christophe, Mathis, Diane
By combining two previously generated null mutations, Ii° and M°, we produced mice lacking the invariant chain and H-2M complexes, both required for normal cell-surface expression of major...
Jugovic, Pieter, Hill, Ann M., Tomazin, Roman, Ploegh, Hidde, Johnson, David C.
Herpes simplex virus types 1 and 2 (HSV-1 and HSV-2) express an immediate-early protein, ICP47, that effectively inhibits the human transporter associated with antigen presentation (TAP), blocking...
Abendroth, Allison, Lin, Ines, Slobedman, Barry, Ploegh, Hidde, Arvin, Ann M.
We sought to examine the effects of varicella-zoster virus (VZV) infection on the expression of major histocompatibility complex class I (MHC I) molecules by human fibroblasts and T lymphocytes. By...
Structural and Functional Analysis of Human Cytomegalovirus US3 Protein
Misaghi, Shahram, Sun, Zhen-Yu J., Stern, Patrick, Gaudet, Rachelle, Wagner, Gerhard, Ploegh, Hidde
Human cytomegalovirus (HCMV) unique short region 3 (US3) protein, a type I membrane protein, prevents maturation of class I major histocompatibility complex (MHC) molecules by retaining them in the...
Discovery of antivirals against smallpox
Harrison, Stephen C., Alberts, Bruce, Ehrenfeld, Ellie, Enquist, Lynn, Fineberg, Harvey, McKnight, Steven L., ...
The SUMO-Specific Protease SENP5 Is Required for Cell Division
Di Bacco, Alessandra, Ouyang, Jian, Lee, Hsiang-Ying, Catic, Andre, Ploegh, Hidde, Gill, Grace
Posttranslational modification of substrates by the small ubiquitin-like modifier, SUMO, regulates diverse biological processes, including transcription, DNA repair, nucleocytoplasmic trafficking,...
Bogyo, Matthew, McMaster, John S., Gaczynska, Maria, Tortorella, Domenico, Goldberg, Alfred L., Ploegh, Hidde
The proteasome is a multicatalytic protease complex that plays a key role in diverse cellular functions. The peptide vinyl sulfone, carboxybenzyl-leucyl-leucyl-leucine vinyl sulfone (Z-L3VS)...
Vugmeyster, Yulia, Glas, Rickard, Pérarnau, Béatrice, Lemonnier, François A., Eisen, Herman, Ploegh, Hidde
We obtained mice deficient for major histocompatibility complex (MHC) molecules encoded by the H-2K and H-2D genes. H-2 KbDb −/− mice express no detectable classical MHC class I-region associated...
Tourne, Sylvie, Miyazaki, Toru, Wolf, Paula, Ploegh, Hidde, Benoist, Christophe, Mathis, Diane
By combining two previously generated null mutations, Ii° and M°, we produced mice lacking the invariant chain and H-2M complexes, both required for normal cell-surface expression of major...
Jugovic, Pieter, Hill, Ann M., Tomazin, Roman, Ploegh, Hidde, Johnson, David C.
Herpes simplex virus types 1 and 2 (HSV-1 and HSV-2) express an immediate-early protein, ICP47, that effectively inhibits the human transporter associated with antigen presentation (TAP), blocking...
Abendroth, Allison, Lin, Ines, Slobedman, Barry, Ploegh, Hidde, Arvin, Ann M.
We sought to examine the effects of varicella-zoster virus (VZV) infection on the expression of major histocompatibility complex class I (MHC I) molecules by human fibroblasts and T lymphocytes. By...
Structural and Functional Analysis of Human Cytomegalovirus US3 Protein
Misaghi, Shahram, Sun, Zhen-Yu J., Stern, Patrick, Gaudet, Rachelle, Wagner, Gerhard, Ploegh, Hidde
Human cytomegalovirus (HCMV) unique short region 3 (US3) protein, a type I membrane protein, prevents maturation of class I major histocompatibility complex (MHC) molecules by retaining them in the...
Discovery of antivirals against smallpox
Harrison, Stephen C., Alberts, Bruce, Ehrenfeld, Ellie, Enquist, Lynn, Fineberg, Harvey, McKnight, Steven L., ...
The SUMO-Specific Protease SENP5 Is Required for Cell Division
Di Bacco, Alessandra, Ouyang, Jian, Lee, Hsiang-Ying, Catic, Andre, Ploegh, Hidde, Gill, Grace
Posttranslational modification of substrates by the small ubiquitin-like modifier, SUMO, regulates diverse biological processes, including transcription, DNA repair, nucleocytoplasmic trafficking,...
Gavanescu, Irina, Kessler, Benedikt, Ploegh, Hidde, Benoist, Christophe, Mathis, Diane
Both humans and mice with a mutation in the autoimmune regulator (aire) gene develop multiorgan autoimmune disease. Aire was shown to exert its critical function in medullary epithelial cells of the...
Das, Gobardhan, Gould, Dina S., Augustine, Mathew M., Fragoso, Gladis, Scitto, Edda, Stroynowski, Iwona, ...
Murine intestinal intraepithelial lymphocytes (iIELs) are made up of a heterogeneous mix of T cells with unique phenotypes. Whereas CD8+ T cells in peripheral lymphoid organs use CD8α/β and are...
Fiebiger, Edda, Meraner, Paul, Weber, Ekkehard, Fang, I-Fei, Stingl, Georg, Ploegh, Hidde, ...
Endo/lysosomal proteases control two key events in antigen (Ag) presentation: the degradation of protein Ag and the generation of peptide-receptive major histocompatibility complex (MHC) class II...
Das, Gobardhan, Gould, Dina S., Augustine, Mathew M., Fragoso, Gladis, Sciutto, Edda, Stroynowski, Iwona, ...
A herpesvirus ubiquitin-specific protease is critical for efficient T cell lymphoma formation
Jarosinski, Keith, Kattenhorn, Lisa, Kaufer, Benedikt, Ploegh, Hidde, Osterrieder, Nikolaus
The herpesvirus ubiquitin-specific protease (USP) family, whose founding member was discovered as a protease domain embedded in the large tegument protein of herpes simplex virus 1 (HSV-1), is...