Fuqu Yu, Josephine N. Harada, Helen J. Brown, Hongyu Deng, Moon Jung Song, Ting-Ting Wu, ...
The herpesvirus life cycle has two distinct phases: latency and lytic replication. The balance between these two phases is critical for viral pathogenesis. It is believed that cellular signals...
Song, Moon Jung, Brown, Helen J., Wu, Ting-Ting, Sun, Ren
Human herpesvirus 8 (HHV-8) (also known as Kaposi's sarcoma-associated herpesvirus) encodes a novel noncoding polyadenylated nuclear (PAN) RNA (also known as T1.1 or nut-1) during the early phase of...
Martel, Lisa S., Brown, Helen J., Berk, Arnold J.
Surfaces of human TATA box-binding protein (hsTBP) required for activated transcription in vivo were defined by constructing a library of surface residue substitution mutations and assaying them for...
Song, Moon Jung, Li, Xudong, Brown, Helen J., Sun, Ren
RTA (replication and transcription activator; also referred to as ORF50, Lyta, and ART), an immediate-early gene product of Kaposi's sarcoma-associated herpesvirus (KSHV)/human herpesvirus 8,...
NF-κB Inhibits Gammaherpesvirus Lytic Replication
Brown, Helen J., Song, Moon Jung, Deng, Hongyu, Wu, Ting-Ting, Cheng, Genhong, Sun, Ren
Nasopharyngeal carcinoma, Kaposi's sarcoma, and B-cell lymphomas are human malignancies associated with gammaherpesvirus infections. Members of this virus family are characterized by their ability to...
Generation of a Latency-Deficient Gammaherpesvirus That Is Protective against Secondary Infection
Rickabaugh, Tammy M., Brown, Helen J., Martinez-Guzman, DeeAnn, Wu, Ting-Ting, Tong, Leming, Yu, Fuqu, ...
Kaposi's sarcoma-associated herpesvirus and murine gammaherpesvirus-68 (MHV-68) establish latent infections and are associated with various types of malignancies. They are members of the gamma-2...
Rickabaugh, Tammy M., Brown, Helen J., Wu, Ting-Ting, Song, Moon Jung, Hwang, Seungmin, Deng, Hongyu, ...
Murine gammaherpesvirus 68 (MHV-68), Kaposi's sarcoma-associated herpesvirus (HHV-8), and Epstein-Barr virus (EBV) are all members of the gammaherpesvirus family, characterized by their ability to...
Chang, Margaret, Brown, Helen J., Collado-Hidalgo, Alicia, Arevalo, Jesusa M., Galic, Zoran, Symensma, Tonia L., ...
Reactivation of Kaposi's sarcoma-associated herpesvirus (KSHV) lytic replication is mediated by the viral RTA transcription factor, but little is known about the physiological processes controlling...
Rapid Expression of Human Immunodeficiency Virus following Activation of Latently Infected Cells
Arlen, Philip A., Brooks, David G., Gao, Lian Y., Vatakis, Dimitrios, Brown, Helen J., Zack, Jerome A.
The host cell activation state impacts the nature of human immunodeficiency virus infection. Activated cells facilitate productive infections; quiescent cells enable the virus to enter a latent...
Song, Moon Jung, Brown, Helen J., Wu, Ting-Ting, Sun, Ren
Human herpesvirus 8 (HHV-8) (also known as Kaposi's sarcoma-associated herpesvirus) encodes a novel noncoding polyadenylated nuclear (PAN) RNA (also known as T1.1 or nut-1) during the early phase of...
Martel, Lisa S., Brown, Helen J., Berk, Arnold J.
Surfaces of human TATA box-binding protein (hsTBP) required for activated transcription in vivo were defined by constructing a library of surface residue substitution mutations and assaying them for...
Song, Moon Jung, Li, Xudong, Brown, Helen J., Sun, Ren
RTA (replication and transcription activator; also referred to as ORF50, Lyta, and ART), an immediate-early gene product of Kaposi's sarcoma-associated herpesvirus (KSHV)/human herpesvirus 8,...
NF-κB Inhibits Gammaherpesvirus Lytic Replication
Brown, Helen J., Song, Moon Jung, Deng, Hongyu, Wu, Ting-Ting, Cheng, Genhong, Sun, Ren
Nasopharyngeal carcinoma, Kaposi's sarcoma, and B-cell lymphomas are human malignancies associated with gammaherpesvirus infections. Members of this virus family are characterized by their ability to...
Generation of a Latency-Deficient Gammaherpesvirus That Is Protective against Secondary Infection
Rickabaugh, Tammy M., Brown, Helen J., Martinez-Guzman, DeeAnn, Wu, Ting-Ting, Tong, Leming, Yu, Fuqu, ...
Kaposi's sarcoma-associated herpesvirus and murine gammaherpesvirus-68 (MHV-68) establish latent infections and are associated with various types of malignancies. They are members of the gamma-2...
Rickabaugh, Tammy M., Brown, Helen J., Wu, Ting-Ting, Song, Moon Jung, Hwang, Seungmin, Deng, Hongyu, ...
Murine gammaherpesvirus 68 (MHV-68), Kaposi's sarcoma-associated herpesvirus (HHV-8), and Epstein-Barr virus (EBV) are all members of the gammaherpesvirus family, characterized by their ability to...
Chang, Margaret, Brown, Helen J., Collado-Hidalgo, Alicia, Arevalo, Jesusa M., Galic, Zoran, Symensma, Tonia L., ...
Reactivation of Kaposi's sarcoma-associated herpesvirus (KSHV) lytic replication is mediated by the viral RTA transcription factor, but little is known about the physiological processes controlling...
Rapid Expression of Human Immunodeficiency Virus following Activation of Latently Infected Cells
Arlen, Philip A., Brooks, David G., Gao, Lian Y., Vatakis, Dimitrios, Brown, Helen J., Zack, Jerome A.
The host cell activation state impacts the nature of human immunodeficiency virus infection. Activated cells facilitate productive infections; quiescent cells enable the virus to enter a latent...
Systematic Identification of Cellular Signals Reactivating Kaposi Sarcoma–Associated Herpesvirus
Yu, Fuqu, Harada, Josephine N, Brown, Helen J, Deng, Hongyu, Song, Moon Jung, Wu, Ting-Ting, ...
The herpesvirus life cycle has two distinct phases: latency and lytic replication. The balance between these two phases is critical for viral pathogenesis. It is believed that cellular signals...
Primary Cell Model for Activation-Inducible Human Immunodeficiency Virus▿
Burke, Bryan, Brown, Helen J., Marsden, Matthew D., Bristol, Gregory, Vatakis, Dimitrios N., Zack, Jerome A.
Quiescent T lymphocytes containing latent human immunodeficiency virus (HIV) provide a long-lived viral reservoir. This reservoir may be the source of active infection that is reinitiated following...