Effective Post-Exposure Treatment of Ebola Infection (2007)
Heinz Feldmann, Steven M. Jones, Joan B. Geisbert, Ute Ströher, Allen Grolla, ...
Ebola viruses are highly lethal human pathogens that have received considerable attention in recent years due to an increasing re-emergence in Central Africa and a potential for use as a biological...
Rapid molecular strategy for filovirus detection and characterization (2007)
Zhai, Junhui, Palacios, Gustavo, Towner, Jonathan S., Jabado, Omar, Kapoor, Vishal, Venter, Marietjie, ...
Filoviruses have the capacity to cause lethal outbreaks of hemorrhagic fever in primates. Here we present a simple consensus reverse transcription-PCR method for filovirus recognition and...
Assembly and Budding of Ebolavirus (2006)
Takeshi Noda, Hideki Ebihara, Yukiko Muramoto, Ken Fujii, Ayato Takada, Hiroshi Sagara, ...
Ebolavirus is responsible for highly lethal hemorrhagic fever. Like all viruses, it must reproduce its various components and assemble them in cells in order to reproduce infectious virions and...
Molecular Determinants of Ebola Virus Virulence in Mice (2006)
Hideki Ebihara, Ayato Takada, Darwyn Kobasa, Steven Jones, Gabriele Neumann, Steven Theriault, ...
Zaire ebolavirus (ZEBOV) causes severe hemorrhagic fever in humans and nonhuman primates, with fatality rates in humans of up to 90%. The molecular basis for the extreme virulence of ZEBOV remains...
Masstag polymerase chain reaction for differential diagnosis of viral hemorrhagic fevers (2006)
Palacios, Gustavo, Briese, Thomas, Kapoor, Vishal, Jabado, Omar, Liu, Zhiqiang, Venter, Marietjie, ...
Viral hemorrhagic fevers are associated with high rates of illness and death. Although therapeutic options are limited, early differential diagnosis has implications for containment and may aid in...
Development of a New Vaccine for the Prevention of Lassa Fever (2005)
Thomas W. Geisbert, Steven Jones, Elizabeth A. Fritz, Amy C. Shurtleff, Joan B. Geisbert, Ryan Liebscher, ...
A replication-competent vaccine based on attenuated recombinant vesicular stomatitis virus vector protects non- human primates.
Development of a New Vaccine for the Prevention of Lassa Fever (2005)
Thomas W. Geisbert, Steven Jones, Elizabeth A. Fritz, Amy C. Shurtleff, Joan B. Geisbert, Ryan Liebscher, ...
Background Recent importation of Lassa fever into Germany, the Netherlands, the United Kingdom, and the United States by travelers on commercial airlines from Africa underscores the public health...
Intracellular localization of Crimean-Congo Hemorrhagic Fever (CCHF) virus glycoproteins (2005)
Haferkamp, Sebastian, Fernando, Lisa, Schwarz, Tino F, Feldmann, Heinz, Flick, Ramon
Abstract Background Crimean-Congo Hemorrhagic Fever virus (CCHFV), a member of the genus Nairovirus , family Bunyaviridae , is a tick-borne pathogen causing severe disease in humans. To better...
Jones, Steven M., Feldmann, Heinz, Stroher, Ute, Geisbert, Joan B., Fernando, Lisa, Grolla, Allen, ...
Vaccines and therapies are urgently needed to address public health needs stemming from emerging pathogens and biological threat agents such as the filoviruses Ebola virus (EBOV) and Marburg virus...
Daddario-DiCaprio, Kathleen M., Geisbert, Thomas W., Stroher, Ute, Geisbert, Joan B., Grolla, Allen, Fritz, Elizabeth A., ...
Effective countermeasures are urgently needed to prevent and treat infections caused by highly pathogenic and biological threat agents such as Marburg virus (MARV). We aimed to test the efficacy of a...
MassTag Polymerase Chain Reaction for Differential Diagnosis of Viral Hemorrhagic Fevers (1998)
Palacios, Gustavo, Briese, Thomas, Kapoor, Vishal, Jabado, Omar, Liu, Zhiqiang, Venter, Marietjie, ...
Viral hemorrhagic fevers are associated with high rates of illness and death. Although therapeutic options are limited, early differential diagnosis has implications for containment and may aid in...
Heidelberg, Med. F., Diss. v. 24. Jan. 1962 (Nicht f. d. Aust.).
Processing of the Ebola virus glycoprotein by the proprotein convertase furin
Volchkov, Viktor E., Feldmann, Heinz, Volchkova, Valentina A., Klenk, Hans-Dieter
In the present study, we have investigated processing and maturation of the envelope glycoprotein (GP) of Ebola virus. When GP expressed from vaccinia virus vectors was analyzed by pulse–chase...
Hemorrhagic Fever with Renal Syndrome: Diagnostic Problems with a Known Disease
Wichmann, Dominic, Slenczka, Werner, Alter, Peter, Boehm, Stephan, Feldmann, Heinz
Hemorrhagic fever with renal syndrome (HFRS), caused by different hantaviruses, is a distinct clinical syndrome endemic in several parts of Asia and Europe. However, the clinical picture can...
Identification of a Novel Consensus Sequence at the Cleavage Site of the Lassa Virus Glycoprotein
Lenz, Oliver, Ter Meulen, Jan, Feldmann, Heinz, Klenk, Hans-Dieter, Garten, Wolfgang
The Lassa virus glycoprotein consists of an amino-terminal and a carboxy-terminal cleavage fragment designated GP-1 and GP-2, respectively, that are derived by proteolysis from the precursor GP-C....
Identification of a Novel Consensus Sequence at the Cleavage Site of the Lassa Virus Glycoprotein
Lenz, Oliver, Ter Meulen, Jan, Feldmann, Heinz, Klenk, Hans-Dieter, Garten, Wolfgang
Infection and Activation of Monocytes by Marburg and Ebola Viruses
Ströher, Ute, West, Elmar, Bugany, Harald, Klenk, Hans-Dieter, Schnittler, Hans-Joachim, Feldmann, Heinz
In this study we investigated the effects of Marburg virus and Ebola virus (species Zaire and Reston) infections on freshly isolated suspended monocytes in comparison to adherent macrophages under...
Neumann, Gabriele, Feldmann, Heinz, Watanabe, Shinji, Lukashevich, Igor, Kawaoka, Yoshihiro
Ebola virus, a prime example of an emerging pathogen, causes fatal hemorrhagic fever in humans and in nonhuman primates. Identification of major determinants of Ebola virus pathogenicity has been...
Hantaan Virus Infection Causes an Acute Neurological Disease That Is Fatal in Adult Laboratory Mice
Wichmann, Dominic, Gröne, Hermann-Josef, Frese, Michael, Pavlovic, Jovan, Anheier, Bärbel, Haller, Otto, ...
Hantaan virus, the etiological agent of Korean hemorrhagic fever, is transmitted to humans from persistently infected mice (Apodemus agrarius), which serve as the primary reservoir. Here we...
Takada, Ayato, Feldmann, Heinz, Stroeher, Ute, Bray, Mike, Watanabe, Shinji, Ito, Hiroshi, ...
Ebola virus causes lethal hemorrhagic fever in humans, but currently there are no effective vaccines or antiviral compounds for this infectious disease. Passive transfer of monoclonal antibodies...
Reverse Genetics for Crimean-Congo Hemorrhagic Fever Virus
Flick, Ramon, Flick, Kirsten, Feldmann, Heinz, Elgh, Fredrik
The widespread geographical distribution of Crimean-Congo hemorrhagic fever (CCHF) virus (more than 30 countries) and its ability to produce severe human disease with high mortality rates (up to 60%)...
Antibody-Dependent Enhancement of Ebola Virus Infection
Takada, Ayato, Feldmann, Heinz, Ksiazek, Thomas G., Kawaoka, Yoshihiro
Most strains of Ebola virus cause a rapidly fatal hemorrhagic disease in humans, yet there are still no biologic explanations that adequately account for the extreme virulence of these emerging...
Takada, Ayato, Fujioka, Kouki, Tsuiji, Makoto, Morikawa, Akiko, Higashi, Nobuaki, Ebihara, Hideki, ...
Filoviruses cause lethal hemorrhagic disease in humans and nonhuman primates. An initial target of filovirus infection is the mononuclear phagocytic cell. Calcium-dependent (C-type) lectins such as...
Cells Expressing the RING Finger Z Protein Are Resistant to Arenavirus Infection
Cornu, Tatjana I., Feldmann, Heinz, De La Torre, Juan Carlos
Arenaviruses include Lassa fever virus (LFV) and the South American hemorrhagic fever viruses. These viruses cause severe human disease, and they pose a threat as agents of bioterrorism. Arenaviruses...
Watanabe, Shinji, Watanabe, Tokiko, Noda, Takeshi, Takada, Ayato, Feldmann, Heinz, Jasenosky, Luke D., ...
We established a plasmid-based system for generating infectious Ebola virus-like particles (VLPs), which contain an Ebola virus-like minigenome consisting of a negative-sense copy of the green...
Garbutt, Michael, Liebscher, Ryan, Wahl-Jensen, Victoria, Jones, Steven, Möller, Peggy, Wagner, Ralf, ...
Replication-competent recombinant vesicular stomatitis viruses (rVSVs) expressing the type I transmembrane glycoproteins and selected soluble glycoproteins of several viral hemorrhagic fever agents...
Hogan, Robert J., Gao, Guangping, Rowe, Thomas, Bell, Peter, Flieder, Douglas, Paragas, Jason, ...
Intranasal inhalation of the severe acute respiratory syndrome coronavirus (SARS CoV) in the immunocompetent mouse strain 129SvEv resulted in infection of conducting airway epithelial cells followed...
Functional Analysis of the Noncoding Regions of the Uukuniemi Virus (Bunyaviridae) RNA Segments
Flick, Kirsten, Katz, Anna, Överby, Anna, Feldmann, Heinz, Pettersson, Ralf F., Flick, Ramon
The role of the variable portion of the noncoding regions (NCRs) of the three Bunyaviridae RNA segments (L, M, S) in transcription, replication, and packaging was studied using the recently developed...
Wahl-Jensen, Victoria, Kurz, Sabine K., Hazelton, Paul R., Schnittler, Hans-Joachim, Ströher, Ute, Burton, Dennis R., ...
Ebola virus, a member of the family Filoviridae, causes one of the most severe forms of viral hemorrhagic fever. In the terminal stages of disease, symptoms progress to hypotension, coagulation...
RNA Polymerase I-Driven Minigenome System for Ebola Viruses
Groseth, Allison, Feldmann, Heinz, Theriault, Steven, Mehmetoglu, Gülsah, Flick, Ramon
In general, Ebola viruses are well known for their ability to cause severe hemorrhagic fever in both human and nonhuman primates. However, despite substantial sequence homology to other members of...
Intracellular localization of Crimean-Congo Hemorrhagic Fever (CCHF) virus glycoproteins
Haferkamp, Sebastian, Fernando, Lisa, Schwarz, Tino F, Feldmann, Heinz, Flick, Ramon
Development of a New Vaccine for the Prevention of Lassa Fever
Geisbert, Thomas W, Jones, Steven, Fritz, Elizabeth A, Shurtleff, Amy C, Geisbert, Joan B, Liebscher, Ryan, ...
A replication-competent vaccine based on attenuated recombinant vesicular stomatitis virus vector protects non- human primates.
Ebola Virus VP40 Late Domains Are Not Essential for Viral Replication in Cell Culture
Neumann, Gabriele, Ebihara, Hideki, Takada, Ayato, Noda, Takeshi, Kobasa, Darwyn, Jasenosky, Luke D., ...
Ebola virus particle formation and budding are mediated by the VP40 protein, which possesses overlapping PTAP and PPXY late domain motifs (7-PTAPPXY-13). These late domain motifs have also been found...
Effects of Ebola Virus Glycoproteins on Endothelial Cell Activation and Barrier Function
Wahl-Jensen, Victoria M., Afanasieva, Tatiana A., Seebach, Jochen, Ströher, Ute, Feldmann, Heinz, Schnittler, Hans-Joachim
Ebola virus causes severe hemorrhagic fever with high mortality rates in humans and nonhuman primates. Vascular instability and dysregulation are disease-decisive symptoms during severe infection....
Molecular Determinants of Ebola Virus Virulence in Mice
Ebihara, Hideki, Takada, Ayato, Kobasa, Darwyn, Jones, Steven, Neumann, Gabriele, Theriault, Steven, ...
Zaire ebolavirus (ZEBOV) causes severe hemorrhagic fever in humans and nonhuman primates, with fatality rates in humans of up to 90%. The molecular basis for the extreme virulence of ZEBOV remains...
Assembly and Budding of Ebolavirus
Noda, Takeshi, Ebihara, Hideki, Muramoto, Yukiko, Fujii, Ken, Takada, Ayato, Sagara, Hiroshi, ...
Ebolavirus is responsible for highly lethal hemorrhagic fever. Like all viruses, it must reproduce its various components and assemble them in cells in order to reproduce infectious virions and...
Hoenen, Thomas, Groseth, Allison, Kolesnikova, Larissa, Theriault, Steven, Ebihara, Hideki, Hartlieb, Bettina, ...
Infectious virus-like particle (iVLP) systems have recently been established for several negative-strand RNA viruses, including the highly pathogenic Zaire ebolavirus (ZEBOV), and allow study of the...
Processing of the Ebola virus glycoprotein by the proprotein convertase furin
Volchkov, Viktor E., Feldmann, Heinz, Volchkova, Valentina A., Klenk, Hans-Dieter
In the present study, we have investigated processing and maturation of the envelope glycoprotein (GP) of Ebola virus. When GP expressed from vaccinia virus vectors was analyzed by pulse–chase...
Hemorrhagic Fever with Renal Syndrome: Diagnostic Problems with a Known Disease
Wichmann, Dominic, Slenczka, Werner, Alter, Peter, Boehm, Stephan, Feldmann, Heinz
Hemorrhagic fever with renal syndrome (HFRS), caused by different hantaviruses, is a distinct clinical syndrome endemic in several parts of Asia and Europe. However, the clinical picture can...
Identification of a Novel Consensus Sequence at the Cleavage Site of the Lassa Virus Glycoprotein
Lenz, Oliver, Ter Meulen, Jan, Feldmann, Heinz, Klenk, Hans-Dieter, Garten, Wolfgang
The Lassa virus glycoprotein consists of an amino-terminal and a carboxy-terminal cleavage fragment designated GP-1 and GP-2, respectively, that are derived by proteolysis from the precursor GP-C....
Identification of a Novel Consensus Sequence at the Cleavage Site of the Lassa Virus Glycoprotein
Lenz, Oliver, Ter Meulen, Jan, Feldmann, Heinz, Klenk, Hans-Dieter, Garten, Wolfgang
Infection and Activation of Monocytes by Marburg and Ebola Viruses
Ströher, Ute, West, Elmar, Bugany, Harald, Klenk, Hans-Dieter, Schnittler, Hans-Joachim, Feldmann, Heinz
In this study we investigated the effects of Marburg virus and Ebola virus (species Zaire and Reston) infections on freshly isolated suspended monocytes in comparison to adherent macrophages under...
Neumann, Gabriele, Feldmann, Heinz, Watanabe, Shinji, Lukashevich, Igor, Kawaoka, Yoshihiro
Ebola virus, a prime example of an emerging pathogen, causes fatal hemorrhagic fever in humans and in nonhuman primates. Identification of major determinants of Ebola virus pathogenicity has been...
Hantaan Virus Infection Causes an Acute Neurological Disease That Is Fatal in Adult Laboratory Mice
Wichmann, Dominic, Gröne, Hermann-Josef, Frese, Michael, Pavlovic, Jovan, Anheier, Bärbel, Haller, Otto, ...
Hantaan virus, the etiological agent of Korean hemorrhagic fever, is transmitted to humans from persistently infected mice (Apodemus agrarius), which serve as the primary reservoir. Here we...
Takada, Ayato, Feldmann, Heinz, Stroeher, Ute, Bray, Mike, Watanabe, Shinji, Ito, Hiroshi, ...
Ebola virus causes lethal hemorrhagic fever in humans, but currently there are no effective vaccines or antiviral compounds for this infectious disease. Passive transfer of monoclonal antibodies...
Reverse Genetics for Crimean-Congo Hemorrhagic Fever Virus
Flick, Ramon, Flick, Kirsten, Feldmann, Heinz, Elgh, Fredrik
The widespread geographical distribution of Crimean-Congo hemorrhagic fever (CCHF) virus (more than 30 countries) and its ability to produce severe human disease with high mortality rates (up to 60%)...
Antibody-Dependent Enhancement of Ebola Virus Infection
Takada, Ayato, Feldmann, Heinz, Ksiazek, Thomas G., Kawaoka, Yoshihiro
Most strains of Ebola virus cause a rapidly fatal hemorrhagic disease in humans, yet there are still no biologic explanations that adequately account for the extreme virulence of these emerging...
Takada, Ayato, Fujioka, Kouki, Tsuiji, Makoto, Morikawa, Akiko, Higashi, Nobuaki, Ebihara, Hideki, ...
Filoviruses cause lethal hemorrhagic disease in humans and nonhuman primates. An initial target of filovirus infection is the mononuclear phagocytic cell. Calcium-dependent (C-type) lectins such as...
Cells Expressing the RING Finger Z Protein Are Resistant to Arenavirus Infection
Cornu, Tatjana I., Feldmann, Heinz, De La Torre, Juan Carlos
Arenaviruses include Lassa fever virus (LFV) and the South American hemorrhagic fever viruses. These viruses cause severe human disease, and they pose a threat as agents of bioterrorism. Arenaviruses...
Watanabe, Shinji, Watanabe, Tokiko, Noda, Takeshi, Takada, Ayato, Feldmann, Heinz, Jasenosky, Luke D., ...
We established a plasmid-based system for generating infectious Ebola virus-like particles (VLPs), which contain an Ebola virus-like minigenome consisting of a negative-sense copy of the green...
Garbutt, Michael, Liebscher, Ryan, Wahl-Jensen, Victoria, Jones, Steven, Möller, Peggy, Wagner, Ralf, ...
Replication-competent recombinant vesicular stomatitis viruses (rVSVs) expressing the type I transmembrane glycoproteins and selected soluble glycoproteins of several viral hemorrhagic fever agents...
Hogan, Robert J., Gao, Guangping, Rowe, Thomas, Bell, Peter, Flieder, Douglas, Paragas, Jason, ...
Intranasal inhalation of the severe acute respiratory syndrome coronavirus (SARS CoV) in the immunocompetent mouse strain 129SvEv resulted in infection of conducting airway epithelial cells followed...
Functional Analysis of the Noncoding Regions of the Uukuniemi Virus (Bunyaviridae) RNA Segments
Flick, Kirsten, Katz, Anna, Överby, Anna, Feldmann, Heinz, Pettersson, Ralf F., Flick, Ramon
The role of the variable portion of the noncoding regions (NCRs) of the three Bunyaviridae RNA segments (L, M, S) in transcription, replication, and packaging was studied using the recently developed...
Wahl-Jensen, Victoria, Kurz, Sabine K., Hazelton, Paul R., Schnittler, Hans-Joachim, Ströher, Ute, Burton, Dennis R., ...
Ebola virus, a member of the family Filoviridae, causes one of the most severe forms of viral hemorrhagic fever. In the terminal stages of disease, symptoms progress to hypotension, coagulation...
RNA Polymerase I-Driven Minigenome System for Ebola Viruses
Groseth, Allison, Feldmann, Heinz, Theriault, Steven, Mehmetoglu, Gülsah, Flick, Ramon
In general, Ebola viruses are well known for their ability to cause severe hemorrhagic fever in both human and nonhuman primates. However, despite substantial sequence homology to other members of...
Intracellular localization of Crimean-Congo Hemorrhagic Fever (CCHF) virus glycoproteins
Haferkamp, Sebastian, Fernando, Lisa, Schwarz, Tino F, Feldmann, Heinz, Flick, Ramon
Development of a New Vaccine for the Prevention of Lassa Fever
Geisbert, Thomas W, Jones, Steven, Fritz, Elizabeth A, Shurtleff, Amy C, Geisbert, Joan B, Liebscher, Ryan, ...
A replication-competent vaccine based on attenuated recombinant vesicular stomatitis virus vector protects non- human primates.
Ebola Virus VP40 Late Domains Are Not Essential for Viral Replication in Cell Culture
Neumann, Gabriele, Ebihara, Hideki, Takada, Ayato, Noda, Takeshi, Kobasa, Darwyn, Jasenosky, Luke D., ...
Ebola virus particle formation and budding are mediated by the VP40 protein, which possesses overlapping PTAP and PPXY late domain motifs (7-PTAPPXY-13). These late domain motifs have also been found...
Effects of Ebola Virus Glycoproteins on Endothelial Cell Activation and Barrier Function
Wahl-Jensen, Victoria M., Afanasieva, Tatiana A., Seebach, Jochen, Ströher, Ute, Feldmann, Heinz, Schnittler, Hans-Joachim
Ebola virus causes severe hemorrhagic fever with high mortality rates in humans and nonhuman primates. Vascular instability and dysregulation are disease-decisive symptoms during severe infection....
Hoenen, Thomas, Groseth, Allison, Kolesnikova, Larissa, Theriault, Steven, Ebihara, Hideki, Hartlieb, Bettina, ...
Infectious virus-like particle (iVLP) systems have recently been established for several negative-strand RNA viruses, including the highly pathogenic Zaire ebolavirus (ZEBOV), and allow study of the...