Restriction beyond the restriction point: mitogen requirement for G2passage (2006)
Foijer, Floris, Te Riele, Hein
Abstract Cell proliferation is dependent on mitogenic signalling. When absent, normal cells cannot pass the G 1 restriction point, resulting in cell cycle arrest. Passage through the G 1 restriction...
DeWeese, Theodore L., Shipman, Jennifer M., Larrier, Nicole A., Buckley, Nicola M., Kidd, LaCreis R., Groopman, John D., ...
Chronic oxidative stress may play a critical role in the pathogenesis of many human cancers. Here, we report that mouse embryonic stem (ES) cells deficient in DNA mismatch repair responded abnormally...
Msh2 status modulates both apoptosis and mutation frequency in the murine small intestine
Toft, Neil J., Winton, Douglas J., Kelly, Jane, Howard, Louise A., Dekker, Marleen, Te Riele, Hein, ...
Deficiency in genes involved in DNA mismatch repair increases susceptibility to cancer, particularly of the colorectal epithelium. Using Msh2 null mice, we demonstrate that this genetic defect...
Overlapping Functions of the pRb Family in the Regulation of rRNA Synthesis
Ciarmatori, Sonia, Scott, Pamela H., Sutcliffe, Josephine E., McLees, Angela, Alzuherri, Hadi M., Dannenberg, Jan-Hermen, ...
The “pocket” proteins pRb, p107, and p130 are a family of negative growth regulators. Previous studies have demonstrated that overexpression of pRb can repress transcription by RNA polymerase...
Rayman, Joseph B., Takahashi, Yasuhiko, Indjeian, Vahan B., Dannenberg, Jan-Hermen, Catchpole, Steven, Watson, Roger J., ...
Despite biochemical and genetic data suggesting that E2F and pRB (pocket protein) families regulate transcription via chromatin-modifying factors, the precise mechanisms underlying gene regulation by...
Dekker, Marleen, Brouwers, Conny, Te Riele, Hein
Gene targeting through homologous recombination in murine embryonic stem (ES) cells is already strongly suppressed by DNA mismatch-repair (MMR)-dependent anti-recombination when targeting construct...
CTG repeat instability and size variation timing in DNA repair-deficient mice
Savouret, Cédric, Brisson, Edith, Essers, Jeroen, Kanaar, Roland, Pastink, Albert, Te Riele, Hein, ...
Type 1 myotonic dystrophy is caused by the expansion of an unstable CTG repeat in the DMPK gene. We have investigated the molecular mechanisms underlying the CTG repeat instability by crossing...
Mouse MutS-like protein Msh5 is required for proper chromosome synapsis in male and female meiosis
De Vries, Sandra S., Baart, Esther B., Dekker, Marleen, Siezen, Ariaan, De Rooij, Dirk G., De Boer, Peter, ...
Members of the mammalian mismatch repair protein family of MutS and MutL homologs have been implicated in postreplicative mismatch correction and chromosome interactions during meiotic recombination....
p107 is a suppressor of retinoblastoma development in pRb-deficient mice
Robanus-Maandag, Els, Dekker, Marleen, Van Der Valk, Martin, Carrozza, Maria-Luisa, Jeanny, Jean-Claude, Dannenberg, Jan-Hermen, ...
Hemizygosity for the retinoblastoma gene RB in man strongly predisposes to retinoblastoma. In the mouse, however, Rb hemizygosity leaves the retina normal, whereas in Rb−/− chimeras pRb-deficient...
Dannenberg, Jan-Hermen, Van Rossum, Agnes, Schuijff, Leontine, Te Riele, Hein
The retinoblastoma suppressor pRB belongs to the family of so-called pocket proteins, which also includes p107 and p130. These proteins may functionally overlap in cell cycle control and tumor...
Savouret, Cédric, Garcia-Cordier, Corinne, Megret, Jérôme, Te Riele, Hein, Junien, Claudine, Gourdon, Geneviève
Myotonic dystrophy type 1 is a neuromuscular affection associated with the expansion of an unstable CTG repeat in the DM protein kinase gene. The disease is characterized by somatic tissue-specific...
Pocket Protein Complexes Are Recruited to Distinct Targets in Quiescent and Proliferating Cells
Balciunaite, Egle, Spektor, Alexander, Lents, Nathan H., Cam, Hugh, Te Riele, Hein, Scime, Anthony, ...
Biochemical and genetic studies have determined that retinoblastoma protein (pRB) tumor suppressor family members have overlapping functions. However, these studies have largely failed to distinguish...
Restriction beyond the restriction point: mitogen requirement for G2 passage
Foijer, Floris, Te Riele, Hein
Cell proliferation is dependent on mitogenic signalling. When absent, normal cells cannot pass the G1 restriction point, resulting in cell cycle arrest. Passage through the G1 restriction point...
DeWeese, Theodore L., Shipman, Jennifer M., Larrier, Nicole A., Buckley, Nicola M., Kidd, LaCreis R., Groopman, John D., ...
Chronic oxidative stress may play a critical role in the pathogenesis of many human cancers. Here, we report that mouse embryonic stem (ES) cells deficient in DNA mismatch repair responded abnormally...
Msh2 status modulates both apoptosis and mutation frequency in the murine small intestine
Toft, Neil J., Winton, Douglas J., Kelly, Jane, Howard, Louise A., Dekker, Marleen, Te Riele, Hein, ...
Deficiency in genes involved in DNA mismatch repair increases susceptibility to cancer, particularly of the colorectal epithelium. Using Msh2 null mice, we demonstrate that this genetic defect...
Overlapping Functions of the pRb Family in the Regulation of rRNA Synthesis
Ciarmatori, Sonia, Scott, Pamela H., Sutcliffe, Josephine E., McLees, Angela, Alzuherri, Hadi M., Dannenberg, Jan-Hermen, ...
The “pocket” proteins pRb, p107, and p130 are a family of negative growth regulators. Previous studies have demonstrated that overexpression of pRb can repress transcription by RNA polymerase...
Rayman, Joseph B., Takahashi, Yasuhiko, Indjeian, Vahan B., Dannenberg, Jan-Hermen, Catchpole, Steven, Watson, Roger J., ...
Despite biochemical and genetic data suggesting that E2F and pRB (pocket protein) families regulate transcription via chromatin-modifying factors, the precise mechanisms underlying gene regulation by...
Dekker, Marleen, Brouwers, Conny, Te Riele, Hein
Gene targeting through homologous recombination in murine embryonic stem (ES) cells is already strongly suppressed by DNA mismatch-repair (MMR)-dependent anti-recombination when targeting construct...
CTG repeat instability and size variation timing in DNA repair-deficient mice
Savouret, Cédric, Brisson, Edith, Essers, Jeroen, Kanaar, Roland, Pastink, Albert, Te Riele, Hein, ...
Type 1 myotonic dystrophy is caused by the expansion of an unstable CTG repeat in the DMPK gene. We have investigated the molecular mechanisms underlying the CTG repeat instability by crossing...
Mouse MutS-like protein Msh5 is required for proper chromosome synapsis in male and female meiosis
De Vries, Sandra S., Baart, Esther B., Dekker, Marleen, Siezen, Ariaan, De Rooij, Dirk G., De Boer, Peter, ...
Members of the mammalian mismatch repair protein family of MutS and MutL homologs have been implicated in postreplicative mismatch correction and chromosome interactions during meiotic recombination....
p107 is a suppressor of retinoblastoma development in pRb-deficient mice
Robanus-Maandag, Els, Dekker, Marleen, Van Der Valk, Martin, Carrozza, Maria-Luisa, Jeanny, Jean-Claude, Dannenberg, Jan-Hermen, ...
Hemizygosity for the retinoblastoma gene RB in man strongly predisposes to retinoblastoma. In the mouse, however, Rb hemizygosity leaves the retina normal, whereas in Rb−/− chimeras pRb-deficient...
Dannenberg, Jan-Hermen, Van Rossum, Agnes, Schuijff, Leontine, Te Riele, Hein
The retinoblastoma suppressor pRB belongs to the family of so-called pocket proteins, which also includes p107 and p130. These proteins may functionally overlap in cell cycle control and tumor...
Savouret, Cédric, Garcia-Cordier, Corinne, Megret, Jérôme, Te Riele, Hein, Junien, Claudine, Gourdon, Geneviève
Myotonic dystrophy type 1 is a neuromuscular affection associated with the expansion of an unstable CTG repeat in the DM protein kinase gene. The disease is characterized by somatic tissue-specific...
Pocket Protein Complexes Are Recruited to Distinct Targets in Quiescent and Proliferating Cells
Balciunaite, Egle, Spektor, Alexander, Lents, Nathan H., Cam, Hugh, Te Riele, Hein, Scime, Anthony, ...
Biochemical and genetic studies have determined that retinoblastoma protein (pRB) tumor suppressor family members have overlapping functions. However, these studies have largely failed to distinguish...
Restriction beyond the restriction point: mitogen requirement for G2 passage
Foijer, Floris, Te Riele, Hein
Cell proliferation is dependent on mitogenic signalling. When absent, normal cells cannot pass the G1 restriction point, resulting in cell cycle arrest. Passage through the G1 restriction point...
Generation of a mouse mutant by oligonucleotide-mediated gene modification in ES cells
Aarts, Marieke, Dekker, Marleen, De Vries, Sandra, Van Der Wal, Anja, Te Riele, Hein
Oligonucleotide-mediated gene targeting is emerging as a powerful tool for the introduction of subtle gene modifications in mouse embryonic stem (ES) cells and the generation of mutant mice. However,...