Heath A. McDonald

2′, 3′-O-(2,4,6,Trinitrophenyl)-ATP and A-317491 are competitive antagonists at a slowly desensitizing chimeric human P2X3 receptor

Neelands, Torben R, Burgard, Edward C, Uchic, Marie E, McDonald, Heath A, Niforatos, Wende, Faltynek, Connie R, ...

Rapid desensitization of ligand-gated ion channel receptors can alter the apparent activity of receptor modulators, as well as make detection of fast-channel activation difficult. Investigation of...

Endogenous opioid mechanisms partially mediate P2X3/P2X2/3-related antinociception in rat models of inflammatory and chemogenic pain but not neuropathic pain

McGaraughty, Steve, Honore, Prisca, Wismer, Carol T, Mikusa, Joseph, Zhu, Chang Z, McDonald, Heath A, ...

P2X3/P2X2/3 receptors have emerged as important components of nociception. However, there is limited information regarding the neurochemical systems that are affected by antagonism of the P2X3/P2X2/3...