Harris A. Gelbard

Tumor Necrosis Factor Alpha-Induced Apoptosis in Human Neuronal Cells: Protection by the Antioxidant N-Acetylcysteine and the Genes bcl-2 and crmA (1995)

Talley, Angela K., Dewhurst, Stephen, Perry, Seth W., Dollard, Sheila C., Gummuluru, Suryaram, Fine, Steven M., ...

Tumor necrosis factor alpha (TNF-α) is a candidate human immunodeficiency virus type 1-induced neurotoxin that contributes to the pathogenesis of AIDS dementia complex. We report here on the effects...

Comparison of Cell Cycle Arrest, Transactivation, and Apoptosis Induced by the Simian Immunodeficiency Virus SIVagm and Human Immunodeficiency Virus Type 1 vpr Genes

Zhu, Yonghong, Gelbard, Harris A., Roshal, Mikhail, Pursell, Shannon, Jamieson, Beth D., Planelles, Vicente

All primate lentiviruses known to date contain one or two open reading frames with homology to the human immunodeficiency virus type 1 (HIV-1) vpr gene. HIV-1 vpr encodes a 96-amino-acid protein with...

Synapses and Sisyphus: life without paraplegin

Gelbard, Harris A.

The family of neurodegenerative diseases known as hereditary spastic parapareses have diverse genetic loci, yet there is a remarkable convergence in the neuropathologic and neurologic phenotype. A...

Synaptic activity becomes excitotoxic in neurons exposed to elevated levels of platelet-activating factor

Bellizzi, Matthew J., Lu, Shao-Ming, Masliah, Eliezer, Gelbard, Harris A.

Neurologic impairment in HIV-1–associated dementia (HAD) and other neuroinflammatory diseases correlates with injury to dendrites and synapses, but how such injury occurs is not known. We...

Comparison of Cell Cycle Arrest, Transactivation, and Apoptosis Induced by the Simian Immunodeficiency Virus SIVagm and Human Immunodeficiency Virus Type 1 vpr Genes

Zhu, Yonghong, Gelbard, Harris A., Roshal, Mikhail, Pursell, Shannon, Jamieson, Beth D., Planelles, Vicente

All primate lentiviruses known to date contain one or two open reading frames with homology to the human immunodeficiency virus type 1 (HIV-1) vpr gene. HIV-1 vpr encodes a 96-amino-acid protein with...

Synapses and Sisyphus: life without paraplegin

Gelbard, Harris A.

The family of neurodegenerative diseases known as hereditary spastic parapareses have diverse genetic loci, yet there is a remarkable convergence in the neuropathologic and neurologic phenotype. A...

Synaptic activity becomes excitotoxic in neurons exposed to elevated levels of platelet-activating factor

Bellizzi, Matthew J., Lu, Shao-Ming, Masliah, Eliezer, Gelbard, Harris A.

Neurologic impairment in HIV-1–associated dementia (HAD) and other neuroinflammatory diseases correlates with injury to dendrites and synapses, but how such injury occurs is not known. We...

HIV-1 Tat Activates Neuronal Ryanodine Receptors with Rapid Induction of the Unfolded Protein Response and Mitochondrial Hyperpolarization

Norman, John P., Perry, Seth W., Reynolds, Holly M., Kiebala, Michelle, De Mesy Bentley, Karen L., Trejo, Margarita, ...

Neurologic disease caused by human immunodeficiency virus type 1 (HIV-1) is ultimately refractory to highly active antiretroviral therapy (HAART) because of failure of complete virus eradication in...