Haihong Wu

A novel family of RNA tetraloop structure forms the recognition site for Saccharomyces cerevisiae RNase III

Wu, Haihong, Yang, Pok K., Butcher, Samuel E., Kang, Sundeep, Chanfreau, Guillaume, Feigon, Juli

RNases III are a family of double-stranded RNA (dsRNA) endoribonucleases involved in the processing and decay of a large number of cellular RNAs as well as in RNA interference. The dsRNA substrates...

DNA A-tract bending in three dimensions: Solving the dA4T4 vs. dT4A4 conundrum

Stefl, Richard, Wu, Haihong, Ravindranathan, Sapna, Sklenář, Vladimír, Feigon, Juli

DNA A-tracts have been defined as four or more consecutive A·T base pairs without a TpA step. When inserted in phase with the DNA helical repeat, bending is manifested macroscopically as anomalous...

Structural basis for recognition of the AGNN tetraloop RNA fold by the double-stranded RNA-binding domain of Rnt1p RNase III

Wu, Haihong, Henras, Anthony, Chanfreau, Guillaume, Feigon, Juli

Specific recognition of double-stranded RNA (dsRNA) by dsRNA-binding domains (dsRBDs) is involved in a large number of biological and regulatory processes. Although structures of dsRBDs in complex...

Biochemical and genomic analysis of substrate recognition by the double-stranded RNA binding domain of yeast RNase III

HENRAS, ANTHONY K., SAM, MUI, HILEY, SHAWNA L., WU, HAIHONG, HUGHES, TIMOTHY R., FEIGON, JULI, ...

Members of the RNase III family of double-stranded RNA (dsRNA) endonucleases are important enzymes of RNA metabolism in eukaryotic cells. Rnt1p is the only known member of the RNase III family of...

Structural study of the H/ACA snoRNP components Nop10p and the 3′ hairpin of U65 snoRNA

KHANNA, MAY, WU, HAIHONG, JOHANSSON, CARINA, CAIZERGUES-FERRER, MICHÈLE, FEIGON, JULI

The H/ACA small nucleolar ribonucleoprotein (snoRNP) complexes guide the modification of uridine to pseudouridine at conserved sites in rRNA. The H/ACA snoRNPs each comprise a target-site-specific...

A novel family of RNA tetraloop structure forms the recognition site for Saccharomyces cerevisiae RNase III

Wu, Haihong, Yang, Pok K., Butcher, Samuel E., Kang, Sundeep, Chanfreau, Guillaume, Feigon, Juli

RNases III are a family of double-stranded RNA (dsRNA) endoribonucleases involved in the processing and decay of a large number of cellular RNAs as well as in RNA interference. The dsRNA substrates...

DNA A-tract bending in three dimensions: Solving the dA4T4 vs. dT4A4 conundrum

Stefl, Richard, Wu, Haihong, Ravindranathan, Sapna, Sklenář, Vladimír, Feigon, Juli

DNA A-tracts have been defined as four or more consecutive A·T base pairs without a TpA step. When inserted in phase with the DNA helical repeat, bending is manifested macroscopically as anomalous...

Structural basis for recognition of the AGNN tetraloop RNA fold by the double-stranded RNA-binding domain of Rnt1p RNase III

Wu, Haihong, Henras, Anthony, Chanfreau, Guillaume, Feigon, Juli

Specific recognition of double-stranded RNA (dsRNA) by dsRNA-binding domains (dsRBDs) is involved in a large number of biological and regulatory processes. Although structures of dsRBDs in complex...

Biochemical and genomic analysis of substrate recognition by the double-stranded RNA binding domain of yeast RNase III

HENRAS, ANTHONY K., SAM, MUI, HILEY, SHAWNA L., WU, HAIHONG, HUGHES, TIMOTHY R., FEIGON, JULI, ...

Members of the RNase III family of double-stranded RNA (dsRNA) endonucleases are important enzymes of RNA metabolism in eukaryotic cells. Rnt1p is the only known member of the RNase III family of...

Structural study of the H/ACA snoRNP components Nop10p and the 3′ hairpin of U65 snoRNA

KHANNA, MAY, WU, HAIHONG, JOHANSSON, CARINA, CAIZERGUES-FERRER, MICHÈLE, FEIGON, JULI

The H/ACA small nucleolar ribonucleoprotein (snoRNP) complexes guide the modification of uridine to pseudouridine at conserved sites in rRNA. The H/ACA snoRNPs each comprise a target-site-specific...

Structural study of elements of Tetrahymena telomerase RNA stem–loop IV domain important for function

Richards, Rebecca J., Wu, Haihong, Trantirek, Lukas, O'Connor, Catherine M., Collins, Kathleen, Feigon, Juli

Tetrahymena telomerase RNA (TER) contains several regions in addition to the template that are important for function. Central among these is the stem–loop IV domain, which is involved in both...

H/ACA small nucleolar RNA pseudouridylation pockets bind substrate RNA to form three-way junctions that position the target U for modification

Wu, Haihong, Feigon, Juli

During the biogenesis of eukaryotic ribosomal RNA (rRNA) and spliceosomal small nuclear RNA (snRNA), uridines at specific sites are converted to pseudouridines by H/ACA ribonucleoprotein particles...