Axin stimulates p53 functions by activation of HIPK2 kinase through multimeric complex formation
Rui, Yanning, Xu, Zhen, Lin, Shuyong, Li, Qinxi, Rui, Hongliang, Luo, Wen, ...
Axin and p53 are tumor suppressors, controlling cell growth, apoptosis, and development. We show that Axin interacts with homeodomain-interacting protein kinase-2 (HIPK2), which is linked to...
Yan, Yong-Bin, Wang, Qi, He, Hua-Wei, Hu, Xin-Yao, Zhang, Ri-Qing, Zhou, Hai-Meng
Unfolding and aggregation are basic problems in protein science with serious biotechnological and medical implications. Probing the sequential events occurring during the unfolding and aggregation...
Yan, Yong-Bin, Wang, Qi, He, Hua-Wei, Zhou, Hai-Meng
Protein thermal aggregation plays a crucial role in protein science and engineering. Despite its biological importance, little is known about the mechanism and pathway(s) involved in the formation of...
Osmophobic Effect of Glycerol on Irreversible Thermal Denaturation of Rabbit Creatine Kinase
Meng, Fan-Guo, Hong, Yuan-Kai, He, Hua-Wei, Lyubarev, Arkadii E., Kurganov, Boris I., Yan, Yong-Bin, ...
Protein stability plays an extremely important role not only in its biological function but also in medical science and protein engineering. Osmolytes provide a general method to protect proteins...
He, Hua-Wei, Zhang, Jun, Zhou, Hai-Meng, Yan, Yong-Bin
Protein conformational changes may be associated with particular properties such as its function, transportation, assembly, tendency to aggregate, and potential cytotoxicity. In this research, the...
Axin stimulates p53 functions by activation of HIPK2 kinase through multimeric complex formation
Rui, Yanning, Xu, Zhen, Lin, Shuyong, Li, Qinxi, Rui, Hongliang, Luo, Wen, ...
Axin and p53 are tumor suppressors, controlling cell growth, apoptosis, and development. We show that Axin interacts with homeodomain-interacting protein kinase-2 (HIPK2), which is linked to...
Yan, Yong-Bin, Wang, Qi, He, Hua-Wei, Hu, Xin-Yao, Zhang, Ri-Qing, Zhou, Hai-Meng
Unfolding and aggregation are basic problems in protein science with serious biotechnological and medical implications. Probing the sequential events occurring during the unfolding and aggregation...
Yan, Yong-Bin, Wang, Qi, He, Hua-Wei, Zhou, Hai-Meng
Protein thermal aggregation plays a crucial role in protein science and engineering. Despite its biological importance, little is known about the mechanism and pathway(s) involved in the formation of...
Osmophobic Effect of Glycerol on Irreversible Thermal Denaturation of Rabbit Creatine Kinase
Meng, Fan-Guo, Hong, Yuan-Kai, He, Hua-Wei, Lyubarev, Arkadii E., Kurganov, Boris I., Yan, Yong-Bin, ...
Protein stability plays an extremely important role not only in its biological function but also in medical science and protein engineering. Osmolytes provide a general method to protect proteins...
He, Hua-Wei, Zhang, Jun, Zhou, Hai-Meng, Yan, Yong-Bin
Protein conformational changes may be associated with particular properties such as its function, transportation, assembly, tendency to aggregate, and potential cytotoxicity. In this research, the...
Yan, Yong-Bin, Zhang, Jun, He, Hua-Wei, Zhou, Hai-Meng
Nonnative protein aggregation, which is a common feature in biotechnology, is also a clinical feature in more than 20 serious degenerative diseases. We studied the specific events of bovine...
Kim, Sung-Hye, Zhang, Jun, Jiang, Yan, Zhou, Hai-Meng, Yan, Yong-Bin
Cyclodextrin is a water-soluble circular oligosaccharide with a cylinder shape characterized by exterior hydrophilic rims and an interior hydrophobic cavity, which makes it an ideal additive to...
The AKAP Yu is required for olfactory long-term memory formation in Drosophila
Lu, Yubing, Lu, Yi-Sheng, Shuai, Yichun, Feng, Chunhua, Tully, Tim, Xie, Zuoping, ...
Extensive neurogenetic analysis has shown that memory formation depends critically on cAMP-protein kinase A (PKA) signaling. Details of how this pathway is involved in memory formation, however,...
Capture of monomeric refolding intermediate of human muscle creatine kinase
Li, Sen, Bai, Ji-Hong, Park, Yong-Doo, Zhou, Hai-Meng
Human muscle creatine kinase (CK) is an enzyme that plays an important physiological role in the energy metabolism of humans. It also serves as a typical model for studying refolding of proteins. A...
Pan, Ji-Cheng, Yu, Zhenhang, Su, Xiao-Yang, Sun, Ye-Qing, Rao, Xue-Ming, Zhou, Hai-Meng
The refolding process and the equilibrium intermediates of urea-denatured arginine kinase (AK) were investigated by 1-anilino-8-naphthalenesulfonate (ANS) intrinsic fluorescence, far-UV circular...
Two-phase unfolding pathway of ribonuclease A during denaturation induced by dithiothreitol
Yan, Yong-Bin, Jiang, Bo, Zhang, Ri-Qing, Zhou, Hai-Meng
The dynamics of the unfolding process of bovine pancreatic ribonuclease A (RNase A) unfolded by dithiothreitol (DTT) at a low concentration of 1:30 were investigated in alkaline phosphate-buffered...
Chaperone-like activity of peptidyl-prolyl cis-trans isomerase during creatine kinase refolding
Ou, Wen-Bin, Luo, Wei, Park, Yong-Doo, Zhou, Hai-Meng
Porcine kidney 18 kD peptidyl-prolyl cis-trans isomerase (PPIase) belongs to the cyclophilin family that is inhibited by the immunosuppressive drug cyclosporin A. The chaperone activity of PPIase was...