Genetic nomenclature for the H-2 complex of the mouse (1974)
Klein, Jan, Shreffler, Donald C., Bach, Fritz H., McDevitt, H. O., Festenstein, F., Snell, G. D., ...
Peer Reviewed
Singer, S M, Umetsu, D T, McDevitt, H O
To better understand the role of class II major histocompatibility complex molecules in both normal and autoimmune responses, we have produced a series of I-Ab transgenic mice. One of these...
Intravenous injection of soluble antigen induces thymic and peripheral T-cells apoptosis.
Liblau, R S, Tisch, R, Shokat, K, Yang, X, Dumont, N, Goodnow, C C, ...
The mechanism by which tolerance is induced via systemic administration of high doses of aqueous antigen has been analyzed by using mice transgenic for a T-cell receptor specific for the influenza...
Gautam, A M, Pearson, C, Quinn, V, McDevitt, H O, Milburn, P J
Invariant chain (Ii) associates with major histocompatibility complex (MHC) class II molecules and is crucial for antigen presentation by class II molecules. The exact nature of Ii interaction with...
Patel, S D, Monaco, J J, McDevitt, H O
The products of the Lmp2 and Lmp7 genes located in the major histocompatibility complex (MHC) class II region are postulated to form part of the proteasome complex. This large, multisubunit complex...
Gautam, A M, Lock, C B, Smilek, D E, Pearson, C I, Steinman, L, McDevitt, H O
The precise mechanisms of failure of immunological tolerance to self proteins are not known. Major histocompatibility complex (MHC) susceptibility alleles, the target peptides, and T cells with...
Yang, X D, Michie, S A, Tisch, R, Karin, N, Steinman, L, McDevitt, H O
To elucidate the role of cell adhesion molecules in the pathogenesis of insulin-dependent diabetes mellitus and to determine the predominant lymphocytic homing pathway(s) involved in the selective...
An Abd transgene prevents diabetes in nonobese diabetic mice by inducing regulatory T cells.
Singer, S M, Tisch, R, Yang, X D, McDevitt, H O
Susceptibility to the human autoimmune disease insulin-dependent diabetes mellitus is strongly associated with particular haplotypes of the major histocompatibility complex (MHC). Similarly, in a...
Yang, X D, Karin, N, Tisch, R, Steinman, L, McDevitt, H O
Leukocyte adhesion to the endothelial venules in the pancreatic islets is thought to be one of the initial steps in the development of insulin-dependent diabetes mellitus. It has been suggested that...
The high degree of polymorphism seen at major histocompatibility complex (MHC) class II loci is a feature unique to the MHC. Most of the beta-chain polymorphism is localized in "hypervariable"...
Van Endert, P M, Lopez, M T, Patel, S D, Monaco, J J, McDevitt, H O
Recently, two subunits of a large cytosolic protease and two putative peptide transporter proteins were found to be encoded by genes within the class II region of the major histocompatibility complex...
Smilek, D E, Wraith, D C, Hodgkinson, S, Dwivedy, S, Steinman, L, McDevitt, H O
Experimental autoimmune encephalomyelitis (EAE) is an experimental demyelinating disease of rodents. In (PL/J x SJL) F1 mice, it is induced by immunization with the myelin basic protein peptide...
Jacob, C O, Aiso, S, Michie, S A, McDevitt, H O, Acha-Orbea, H
The role of tumor necrosis factor alpha (TNF-alpha) in the pathogenesis of autoimmune diabetes mellitus was tested in the nonobese mouse (NOD) model system. The effects of TNF-alpha were assessed on...
Jacob, C O, Fronek, Z, Lewis, G D, Koo, M, Hansen, J A, McDevitt, H O
We report on the production of tumor necrosis factor (TNF)-alpha and TNF-beta by mitogen-activated peripheral blood lymphocytes or enriched monocyte subpopulations from human leukocyte antigen...
Gilfillan, S, Aiso, S, Michie, S A, McDevitt, H O
We have recently described 12 lines of H-2s/s mice carrying from 1 to 65 copies of an A beta k transgene. The transgene was coexpressed with the endogenous allele, and A beta K mRNA expression...
Immune deficiency due to high copy numbers of an Ak beta transgene.
Gilfillan, S, Aiso, S, Michie, S A, McDevitt, H O
Because allelic polymorphism of the major histocompatibility complex class II antigens affects the immune response at several levels, we wished to characterize the contribution of a particular alpha...
Morel, P A, Dorman, J S, Todd, J A, McDevitt, H O, Trucco, M
One hundred seventy-two members from 27 randomly selected multiple case Caucasian families of patients with insulin-dependent diabetes mellitus (IDDM) were studied at the DNA level to ascertain the...
Sakai, K, Sinha, A A, Mitchell, D J, Zamvil, S S, Rothbard, J B, McDevitt, H O, ...
The peptide p89-101 (Val-His-Phe-Phe-Lys-Asn-Ile-Val-Thr-Pro-Arg-Thr-Pro) of myelin basic protein is encephalitogenic in mice expressing H-2q and H-2s antigens. Six of 13 encephalitogen-specific...
Allelic variation in the DR subregion of the human major histocompatibility complex.
Bell, J I, Denney, D, Foster, L, Belt, T, Todd, J A, McDevitt, H O
Allelic variation in the DR subregion of the human major histocompatibility complex has been analyzed by nucleic acid sequencing of cDNA clones obtained from cell lines homozygous by consanguinity...
The first external domain of the nonobese diabetic mouse class II I-A beta chain is unique.
The nonobese diabetic mouse is recognized as an important animal model for human insulin-dependent diabetes mellitus. One of the components of susceptibility to this disease has been mapped to the...
HLA-DR2 subtypes form an additional supertypic family of DR beta alleles.
Lee, B S, Rust, N A, McMichael, A J, McDevitt, H O
Homozygous lymphoblastoid cell lines representing Dw subtypes of the DR2 serotype were studied for structural polymorphism at DR beta. These subtypes included Dw2, Dw12, and non-Dw2/non-Dw12....
Estess, P, Begovich, A B, Koo, M, Jones, P P, McDevitt, H O
I-A beta-chain cDNA clones from mice of the q, k, u, s, and f haplotypes have been isolated and sequenced. Nucleotide sequence comparisons among these five A beta chains show considerable allelic...
Identification of a fourth class of proteins linked to the murine major histocompatibility complex.
A series of proteins biochemically and genetically distinct from previously defined murine major histocompatibility complex class I and class II antigens is precipitated by a congeneic anti-H-2d...
In vivo or in vitro treatments with anti-I-J alloantisera abolish immunity to AKR leukemia.
Meruelo, D, Flieger, N, Smith, D, McDevitt, H O
This paper provides evidence for the involvement of immune mechanisms in conferring resistance to a spontaneous AKR leukemia. It is shown that genes in the B, J, or E subregions of the H-2 complex...
Steinman, L, Rosenbaum, J T, Sriram, S, McDevitt, H O
Prevention of experimental allergic encephalitis in SJL/J [H-2s] mice was achieved with in vivo administration of antibody reactive with I-As gene products prior to immunization with spinal cord...
Interaction between I region loci influences the expression of a cell surface Ia antigen.
Murphy, D B, Jones, P P, Loken, M R, McDevitt, H O
Loci clustered in the I region of the murine H-2 gene complex control the capacity to generate an immune response against foreign antigens (Ir loci) and control differentiation antigens which appear...
Monoclonal antibodies reacting with murine teratocarcinoma cells.
Goodfellow, P N, Levinson, J R, Williams, V E, McDevitt, H O
Monoclonal antibodies were produced in vitro by fusing mouse myeloma cells with spleen cells from a rat immunized with the C3H mouse teratocarcinoma C86-S1. After the fusion two clones were chosen...
HLA-B locus polymorphism: studies with a specific hybridization probe.
Coppin, H L, Denny, D W, Weissman, S M, McDevitt, H O
The large number of class I histocompatibility genes (HLA) and their extensive homology has made it difficult to assign bands on genomic Southern blots to known genes. Therefore, we have tried to...
Boitard, C, Michie, S, Serrurier, P, Butcher, G W, Larkins, A P, McDevitt, H O
Evidence is accumulating that the development of insulin-dependent diabetes mellitus involves autoimmune phenomena, both in the human and in the BB rat model. A strong association is observed in both...
Several mechanisms can account for defective E alpha gene expression in different mouse haplotypes.
Mathis, D J, Benoist, C, Williams, V E, Kanter, M, McDevitt, H O
The murine Ia antigens, encoded by the I region of the major histocompatibility complex, are cell-surface glyco-proteins (consisting of alpha and beta polypeptides) thought to be involved in the...
The murine Ia alpha chains, E alpha and A alpha, show a surprising degree of sequence homology.
Benoist, C O, Mathis, D J, Kanter, M R, Williams, V E, McDevitt, H O
The I region of the murine major histocompatibility complex codes for a group of glycoproteins, the Ia antigens, thought to be involved in the control of immune responsiveness. Each Ia antigen...
Das, H K, Biro, P A, Cohen, S N, Erlich, H A, Von Gabain, A, Lawrance, S K, ...
We have synthesized 175-nucleotide-long probes for the DNA of human histocompatibility antigens HLA-DR alpha and beta by extending on poly(A)+ mRNA from B-cell lines with short synthetic...
Predicted protein sequence of the murine I-E-beta S-polypeptide chain from cDNA and genomic clones.
Ia antigens are polymorphic cell-surface glycoprotein complexes, encoded within the I region of the mouse major histocompatibility complex, that control the ability of the organism to mount effective...
Bell, J I, Estess, P, St John, T, Saiki, R, Watling, D L, Erlich, H A, ...
Two HLA class II beta-chain clones from a cell line homozygous for the DR1 haplotype have been characterized and sequenced. They represent a DR beta chain (2918.4) and a DQ beta chain (2918.8). Clone...
Analysis of HLA-D region-associated molecules with monoclonal antibody.
A group of monoclonal antibodies directed against nonpolymorphic HLA-D antigens (human Ia antigens) was produced by somatic cell hybridization. One of these antibodies was used to analyze the...
McMillan, M, Cecka, J M, Murphy, D B, McDevitt, H O, Hood, L
Partial amino acid sequence of the Ia molecule encoded by the I-E or I-C (I-EC) subregion of the major histocompatibility complex of the mouse are presented. The Ia molecule appears to be comprised...
Isolation and characterization of a cDNA clone for the murine I-E beta polypeptide chain.
The Ia antigens, encoded within the I region of the major histocompatibility complex, are a group of cell surface glycoproteins that are involved in the control of immune responsiveness. We isolated...
Singer, S M, Umetsu, D T, McDevitt, H O
To better understand the role of class II major histocompatibility complex molecules in both normal and autoimmune responses, we have produced a series of I-Ab transgenic mice. One of these...
Intravenous injection of soluble antigen induces thymic and peripheral T-cells apoptosis.
Liblau, R S, Tisch, R, Shokat, K, Yang, X, Dumont, N, Goodnow, C C, ...
The mechanism by which tolerance is induced via systemic administration of high doses of aqueous antigen has been analyzed by using mice transgenic for a T-cell receptor specific for the influenza...
Gautam, A M, Pearson, C, Quinn, V, McDevitt, H O, Milburn, P J
Invariant chain (Ii) associates with major histocompatibility complex (MHC) class II molecules and is crucial for antigen presentation by class II molecules. The exact nature of Ii interaction with...
Patel, S D, Monaco, J J, McDevitt, H O
The products of the Lmp2 and Lmp7 genes located in the major histocompatibility complex (MHC) class II region are postulated to form part of the proteasome complex. This large, multisubunit complex...
Gautam, A M, Lock, C B, Smilek, D E, Pearson, C I, Steinman, L, McDevitt, H O
The precise mechanisms of failure of immunological tolerance to self proteins are not known. Major histocompatibility complex (MHC) susceptibility alleles, the target peptides, and T cells with...
Yang, X D, Michie, S A, Tisch, R, Karin, N, Steinman, L, McDevitt, H O
To elucidate the role of cell adhesion molecules in the pathogenesis of insulin-dependent diabetes mellitus and to determine the predominant lymphocytic homing pathway(s) involved in the selective...
An Abd transgene prevents diabetes in nonobese diabetic mice by inducing regulatory T cells.
Singer, S M, Tisch, R, Yang, X D, McDevitt, H O
Susceptibility to the human autoimmune disease insulin-dependent diabetes mellitus is strongly associated with particular haplotypes of the major histocompatibility complex (MHC). Similarly, in a...
Yang, X D, Karin, N, Tisch, R, Steinman, L, McDevitt, H O
Leukocyte adhesion to the endothelial venules in the pancreatic islets is thought to be one of the initial steps in the development of insulin-dependent diabetes mellitus. It has been suggested that...
The high degree of polymorphism seen at major histocompatibility complex (MHC) class II loci is a feature unique to the MHC. Most of the beta-chain polymorphism is localized in "hypervariable"...
Van Endert, P M, Lopez, M T, Patel, S D, Monaco, J J, McDevitt, H O
Recently, two subunits of a large cytosolic protease and two putative peptide transporter proteins were found to be encoded by genes within the class II region of the major histocompatibility complex...
Smilek, D E, Wraith, D C, Hodgkinson, S, Dwivedy, S, Steinman, L, McDevitt, H O
Experimental autoimmune encephalomyelitis (EAE) is an experimental demyelinating disease of rodents. In (PL/J x SJL) F1 mice, it is induced by immunization with the myelin basic protein peptide...
Jacob, C O, Aiso, S, Michie, S A, McDevitt, H O, Acha-Orbea, H
The role of tumor necrosis factor alpha (TNF-alpha) in the pathogenesis of autoimmune diabetes mellitus was tested in the nonobese mouse (NOD) model system. The effects of TNF-alpha were assessed on...
Jacob, C O, Fronek, Z, Lewis, G D, Koo, M, Hansen, J A, McDevitt, H O
We report on the production of tumor necrosis factor (TNF)-alpha and TNF-beta by mitogen-activated peripheral blood lymphocytes or enriched monocyte subpopulations from human leukocyte antigen...
Gilfillan, S, Aiso, S, Michie, S A, McDevitt, H O
We have recently described 12 lines of H-2s/s mice carrying from 1 to 65 copies of an A beta k transgene. The transgene was coexpressed with the endogenous allele, and A beta K mRNA expression...
Immune deficiency due to high copy numbers of an Ak beta transgene.
Gilfillan, S, Aiso, S, Michie, S A, McDevitt, H O
Because allelic polymorphism of the major histocompatibility complex class II antigens affects the immune response at several levels, we wished to characterize the contribution of a particular alpha...
Morel, P A, Dorman, J S, Todd, J A, McDevitt, H O, Trucco, M
One hundred seventy-two members from 27 randomly selected multiple case Caucasian families of patients with insulin-dependent diabetes mellitus (IDDM) were studied at the DNA level to ascertain the...
Sakai, K, Sinha, A A, Mitchell, D J, Zamvil, S S, Rothbard, J B, McDevitt, H O, ...
The peptide p89-101 (Val-His-Phe-Phe-Lys-Asn-Ile-Val-Thr-Pro-Arg-Thr-Pro) of myelin basic protein is encephalitogenic in mice expressing H-2q and H-2s antigens. Six of 13 encephalitogen-specific...
Allelic variation in the DR subregion of the human major histocompatibility complex.
Bell, J I, Denney, D, Foster, L, Belt, T, Todd, J A, McDevitt, H O
Allelic variation in the DR subregion of the human major histocompatibility complex has been analyzed by nucleic acid sequencing of cDNA clones obtained from cell lines homozygous by consanguinity...
The first external domain of the nonobese diabetic mouse class II I-A beta chain is unique.
The nonobese diabetic mouse is recognized as an important animal model for human insulin-dependent diabetes mellitus. One of the components of susceptibility to this disease has been mapped to the...
HLA-DR2 subtypes form an additional supertypic family of DR beta alleles.
Lee, B S, Rust, N A, McMichael, A J, McDevitt, H O
Homozygous lymphoblastoid cell lines representing Dw subtypes of the DR2 serotype were studied for structural polymorphism at DR beta. These subtypes included Dw2, Dw12, and non-Dw2/non-Dw12....
Estess, P, Begovich, A B, Koo, M, Jones, P P, McDevitt, H O
I-A beta-chain cDNA clones from mice of the q, k, u, s, and f haplotypes have been isolated and sequenced. Nucleotide sequence comparisons among these five A beta chains show considerable allelic...
Identification of a fourth class of proteins linked to the murine major histocompatibility complex.
A series of proteins biochemically and genetically distinct from previously defined murine major histocompatibility complex class I and class II antigens is precipitated by a congeneic anti-H-2d...
In vivo or in vitro treatments with anti-I-J alloantisera abolish immunity to AKR leukemia.
Meruelo, D, Flieger, N, Smith, D, McDevitt, H O
This paper provides evidence for the involvement of immune mechanisms in conferring resistance to a spontaneous AKR leukemia. It is shown that genes in the B, J, or E subregions of the H-2 complex...
Steinman, L, Rosenbaum, J T, Sriram, S, McDevitt, H O
Prevention of experimental allergic encephalitis in SJL/J [H-2s] mice was achieved with in vivo administration of antibody reactive with I-As gene products prior to immunization with spinal cord...
Interaction between I region loci influences the expression of a cell surface Ia antigen.
Murphy, D B, Jones, P P, Loken, M R, McDevitt, H O
Loci clustered in the I region of the murine H-2 gene complex control the capacity to generate an immune response against foreign antigens (Ir loci) and control differentiation antigens which appear...
Monoclonal antibodies reacting with murine teratocarcinoma cells.
Goodfellow, P N, Levinson, J R, Williams, V E, McDevitt, H O
Monoclonal antibodies were produced in vitro by fusing mouse myeloma cells with spleen cells from a rat immunized with the C3H mouse teratocarcinoma C86-S1. After the fusion two clones were chosen...
HLA-B locus polymorphism: studies with a specific hybridization probe.
Coppin, H L, Denny, D W, Weissman, S M, McDevitt, H O
The large number of class I histocompatibility genes (HLA) and their extensive homology has made it difficult to assign bands on genomic Southern blots to known genes. Therefore, we have tried to...
Boitard, C, Michie, S, Serrurier, P, Butcher, G W, Larkins, A P, McDevitt, H O
Evidence is accumulating that the development of insulin-dependent diabetes mellitus involves autoimmune phenomena, both in the human and in the BB rat model. A strong association is observed in both...
Several mechanisms can account for defective E alpha gene expression in different mouse haplotypes.
Mathis, D J, Benoist, C, Williams, V E, Kanter, M, McDevitt, H O
The murine Ia antigens, encoded by the I region of the major histocompatibility complex, are cell-surface glyco-proteins (consisting of alpha and beta polypeptides) thought to be involved in the...