Guttorm Haraldsen

Endothelial cell diversity revealed by global expression profiling

Chi, Jen-Tsan, Chang, Howard Y., Haraldsen, Guttorm, Jahnsen, Frode L., Troyanskaya, Olga G., Chang, Dustin S., ...

The vascular system is locally specialized to accommodate widely varying blood flow and pressure and the distinct needs of individual tissues. The endothelial cells (ECs) that line the lumens of...

Endothelial cell diversity revealed by global expression profiling

Chi, Jen-Tsan, Chang, Howard Y., Haraldsen, Guttorm, Jahnsen, Frode L., Troyanskaya, Olga G., Chang, Dustin S., ...

The vascular system is locally specialized to accommodate widely varying blood flow and pressure and the distinct needs of individual tissues. The endothelial cells (ECs) that line the lumens of...

Heterogeneity of Endothelial Cells : The Specialized Phenotype of Human High Endothelial Venules Characterized by Suppression Subtractive Hybridization

Girard, Jean-Philippe, Baekkevold, Espen S., Yamanaka, Takeshi, Haraldsen, Guttorm, Brandtzaeg, Per, Amalric, François

High endothelial venules (HEVs) are specialized postcapillary venules, found in lymphoid organs and chronically inflamed tissues, that support high levels of lymphocyte extravasation from the blood....

Vascular Morphogenesis and Differentiation after Adoptive Transfer of Human Endothelial Cells to Immunodeficient Mice

Skovseth, Dag K., Yamanaka, Takeshi, Brandtzaeg, Per, Butcher, Eugene C., Haraldsen, Guttorm

To establish a model for adoptive transfer of endothelial cells, we transferred human umbilical vein endothelial cells (HUVECs) to immunodeficient mice (Rag 2−/−). HUVECs were suspended as single...

Molecular Characterization of NF-HEV, a Nuclear Factor Preferentially Expressed in Human High Endothelial Venules

Baekkevold, Espen S., Roussigné, Myriam, Yamanaka, Takeshi, Johansen, Finn-Eirik, Jahnsen, Frode L., Amalric, François, ...

Lymphocyte homing to secondary lymphoid tissue and lesions of chronic inflammation is directed by multi-step interactions between the circulating cells and the specialized endothelium of high...

A role for CCR4 in development of mature circulating cutaneous T helper memory cell populations

Baekkevold, Espen S., Wurbel, Marc-André, Kivisäkk, Pia, Wain, Clare M., Power, Christine A., Haraldsen, Guttorm, ...

Expression of the chemokine receptor CCR4 is strongly associated with trafficking of specialized cutaneous memory T helper (Th) lymphocytes to the skin. However, it is unknown whether CCR4 itself...

Lymphocyte Cc Chemokine Receptor 9 and Epithelial Thymus-Expressed Chemokine (Teck) Expression Distinguish the Small Intestinal Immune Compartment: Epithelial Expression of Tissue-Specific Chemokines as an Organizing Principle in Regional Immunity

Kunkel, Eric J., Campbell, James J., Haraldsen, Guttorm, Pan, Junliang, Boisvert, Judie, Roberts, Arthur I., ...

The immune system has evolved specialized cellular and molecular mechanisms for targeting and regulating immune responses at epithelial surfaces. Here we show that small intestinal intraepithelial...

The Ccr7 Ligand ELC (Ccl19) Is Transcytosed in High Endothelial Venules and Mediates T Cell Recruitment

Baekkevold, Espen S., Yamanaka, Takeshi, Palframan, Roger T., Carlsen, Hege S., Reinholt, Finn P., Von Andrian, Ulrich H., ...

Lymphocyte homing to secondary lymphoid tissue is defined by a multistep sequence of interactions between lymphocytes and endothelial cells in high endothelial venules (HEVs). After initial...

Rapid Secretion of Prestored Interleukin 8 from Weibel-Palade Bodies of Microvascular Endothelial Cells

Utgaard, Jon Olav, Jahnsen, Frode L., Bakka, Arne, Brandtzaeg, Per, Haraldsen, Guttorm

Interleukin (IL)-8, a C-X-C chemokine, activates integrin-mediated adhesion of neutrophils. Presentation of IL-8 on the endothelial cell surface may promote leukocyte extravasation. We found that...