Perfettini, Jean-Luc, Nardacci, Roberta, Bourouba, Mehdi, Subra, Frédéric, Gros, Laurent, Séror, Claire, ...
DNA damage can activate the oncosuppressor protein ataxia telangiectasia mutated (ATM), which phosphorylates the histone H2AX within characteristic DNA damage foci. Here, we show that ATM undergoes...
Perfettini, Jean-Luc, Nardacci, Roberta, Bourouba, Mehdi, Subra, Frédéric, Gros, Laurent, Séror, Claire, ...
DNA damage can activate the oncosuppressor protein ataxia telangiectasia mutated (ATM), which phosphorylates the histone H2AX within characteristic DNA damage foci. Here, we show that ATM undergoes...
An AIF orthologue regulates apoptosis in yeast (2004)
Wissing, Silke, Ludovico, Paula, Herker, Eva, Buttner, Sabrina, Engelhardt, Silvia, Decker, Thorsten, ...
Apoptosis-inducing factor (AIF), a key regulator of cell death, is essential for normal mammalian development and participates in pathological apoptosis. The proapoptotic nature of AIF and its mode...
Ferrand-Drake, Michel, Zhu, Changlian, Gidö, Gunilla, Hansen, Anker J, Karlsson, Jan-Olof, Bahr, Ben A, ...
Abstract is not available
Gonzalo, José Ángel, González García, Ana, Martínez-Alonso, Carlos, Kroemer, Guido
El copyright pertenece a The Rockefeller University Press
Andreu-Sánchez, Jose L., Moreno De Alborán, Ignacio, Marcos, Miguel A.R., Sánchez-Movilla, Arsenio, Martínez-Alonso, Carlos, Kroemer, Guido
El copyright pertenece a The Rockefeller University Press
Boya, Patricia, Roques, Bernard, Kroemer, Guido
Mitochondrial membrane permeabilization (MMP) is a critical step of several apoptotic pathways. Some infectious intracellular pathogens can regulate (induce or inhibit) apoptosis of their host cells...
Sequential involvement of Cdk1, mTOR and p53 in apoptosis induced by the HIV-1 envelope
Castedo, Maria, Roumier, Thomas, Blanco, Julià, Ferri, Karine F., Barretina, Jordi, Tintignac, Lionel A., ...
Syncytia arising from the fusion of cells expressing the HIV-1-encoded Env gene with cells expressing the CD4/CXCR4 complex undergo apoptosis following the nuclear translocation of mammalian target...
Mutant MyoD Lacking Cdc2 Phosphorylation Sites Delays M-Phase Entry
Tintignac, Lionel A. J., Sirri, Valentina, Leibovitch, Marie Pierre, Lécluse, Yann, Castedo, Maria, Metivier, Didier, ...
The transcription factors MyoD and Myf-5 control myoblast identity and differentiation. MyoD and Myf-5 manifest opposite cell cycle-specific expression patterns. Here, we provide evidence that MyoD...
AIF deficiency compromises oxidative phosphorylation
Vahsen, Nicola, Candé, Céline, Brière, Jean-Jacques, Bénit, Paule, Joza, Nicholas, Larochette, Nathanael, ...
Apoptosis-inducing factor (AIF) is a mitochondrial flavoprotein that, after apoptosis induction, translocates to the nucleus where it participates in apoptotic chromatinolysis. Here, we show that...
Inhibition of Macroautophagy Triggers Apoptosis†
Boya, Patricia, González-Polo, Rosa-Ana, Casares, Noelia, Perfettini, Jean-Luc, Dessen, Philippe, Larochette, Nathanael, ...
Mammalian cells were observed to die under conditions in which nutrients were depleted and, simultaneously, macroautophagy was inhibited either genetically (by a small interfering RNA targeting Atg5,...
Marriott, Helen M., Bingle, Colin D., Read, Robert C., Braley, Karen E., Kroemer, Guido, Hellewell, Paul G., ...
Macrophages are critical effectors of bacterial clearance and must retain viability, despite exposure to toxic bacterial products, until key antimicrobial functions are performed. Subsequently,...
Weaver, Joel G.R., Tarze, Agathe, Moffat, Tia C., LeBras, Morgane, Deniaud, Aurelien, Brenner, Catherine, ...
Inhibitors of HIV protease have been shown to have antiapoptotic effects in vitro, yet whether these effects are seen in vivo remains controversial. In this study, we have evaluated the impact of the...
Pharmacological manipulation of cell death: clinical applications in sight?
Green, Douglas R., Kroemer, Guido
This series of Reviews on cell death explores the creation of new therapies for correcting excessive or deficient cell death in human disease. Signal transduction pathways controlling cell death and...
Joza, Nicholas, Oudit, Gavin Y., Brown, Doris, Bénit, Paule, Kassiri, Zamaneh, Vahsen, Nicola, ...
Cardiac and skeletal muscle critically depend on mitochondrial energy metabolism for their normal function. Recently, we showed that apoptosis-inducing factor (AIF), a mitochondrial protein...
Boya, Patricia, Roques, Bernard, Kroemer, Guido
Mitochondrial membrane permeabilization (MMP) is a critical step of several apoptotic pathways. Some infectious intracellular pathogens can regulate (induce or inhibit) apoptosis of their host cells...
Sequential involvement of Cdk1, mTOR and p53 in apoptosis induced by the HIV-1 envelope
Castedo, Maria, Roumier, Thomas, Blanco, Julià, Ferri, Karine F., Barretina, Jordi, Tintignac, Lionel A., ...
Syncytia arising from the fusion of cells expressing the HIV-1-encoded Env gene with cells expressing the CD4/CXCR4 complex undergo apoptosis following the nuclear translocation of mammalian target...
Mutant MyoD Lacking Cdc2 Phosphorylation Sites Delays M-Phase Entry
Tintignac, Lionel A. J., Sirri, Valentina, Leibovitch, Marie Pierre, Lécluse, Yann, Castedo, Maria, Metivier, Didier, ...
The transcription factors MyoD and Myf-5 control myoblast identity and differentiation. MyoD and Myf-5 manifest opposite cell cycle-specific expression patterns. Here, we provide evidence that MyoD...
AIF deficiency compromises oxidative phosphorylation
Vahsen, Nicola, Candé, Céline, Brière, Jean-Jacques, Bénit, Paule, Joza, Nicholas, Larochette, Nathanael, ...
Apoptosis-inducing factor (AIF) is a mitochondrial flavoprotein that, after apoptosis induction, translocates to the nucleus where it participates in apoptotic chromatinolysis. Here, we show that...
Inhibition of Macroautophagy Triggers Apoptosis†
Boya, Patricia, González-Polo, Rosa-Ana, Casares, Noelia, Perfettini, Jean-Luc, Dessen, Philippe, Larochette, Nathanael, ...
Mammalian cells were observed to die under conditions in which nutrients were depleted and, simultaneously, macroautophagy was inhibited either genetically (by a small interfering RNA targeting Atg5,...
Marriott, Helen M., Bingle, Colin D., Read, Robert C., Braley, Karen E., Kroemer, Guido, Hellewell, Paul G., ...
Macrophages are critical effectors of bacterial clearance and must retain viability, despite exposure to toxic bacterial products, until key antimicrobial functions are performed. Subsequently,...
Weaver, Joel G.R., Tarze, Agathe, Moffat, Tia C., LeBras, Morgane, Deniaud, Aurelien, Brenner, Catherine, ...
Inhibitors of HIV protease have been shown to have antiapoptotic effects in vitro, yet whether these effects are seen in vivo remains controversial. In this study, we have evaluated the impact of the...
Pharmacological manipulation of cell death: clinical applications in sight?
Green, Douglas R., Kroemer, Guido
This series of Reviews on cell death explores the creation of new therapies for correcting excessive or deficient cell death in human disease. Signal transduction pathways controlling cell death and...
Joza, Nicholas, Oudit, Gavin Y., Brown, Doris, Bénit, Paule, Kassiri, Zamaneh, Vahsen, Nicola, ...
Cardiac and skeletal muscle critically depend on mitochondrial energy metabolism for their normal function. Recently, we showed that apoptosis-inducing factor (AIF), a mitochondrial protein...
Apoptosome-Independent Activation of the Lysosomal Cell Death Pathway by Caspase-9▿ †
Gyrd-Hansen, Mads, Farkas, Thomas, Fehrenbacher, Nicole, Bastholm, Lone, Høyer-Hansen, Maria, Elling, Folmer, ...
The apoptosome, a heptameric complex of Apaf-1, cytochrome c, and caspase-9, has been considered indispensable for the activation of caspase-9 during apoptosis. By using a large panel of genetically...
Characterization of Cell Death Pathways in Human Immunodeficiency Virus-Associated Encephalitis
Nardacci, Roberta, Antinori, Andrea, Larocca, Luigi Maria, Arena, Vincenzo, Amendola, Alessandra, Perfettini, Jean-Luc, ...
Human immunodeficiency virus (HIV)-associated dementia is a neurodegenerative syndrome characterized by cognitive decline, personality change, and motor deficits. HIV-associated encephalitis (HAE),...
Apoptosis regulation in tetraploid cancer cells
Castedo, Maria, Coquelle, Arnaud, Vivet, Sonia, Vitale, Ilio, Kauffmann, Audrey, Dessen, Philippe, ...
Tetraploidy can result in cancer-associated aneuploidy. As shown here, freshly generated tetraploid cells arising due to mitotic slippage or failed cytokinesis are prone to undergo Bax-dependent...
Granville, David J., Cassidy, Brighid A., Ruehlmann, Dietrich O., Choy, Jonathan C., Brenner, Catherine, Kroemer, Guido, ...
Photodynamic therapy (PDT) is under investigation for the treatment of intimal hyperplastia in conditions such as atherosclerosis and restenosis. Although smooth muscle cells (SMCs) may be a key...
Hisatomi, Toshio, Sakamoto, Taiji, Sonoda, Koh-hei, Tsutsumi, Chikako, Qiao, Hong, Enaida, Hiroshi, ...
The effective phagocytotic clearance of apoptotic debris is fundamental to the maintenance of neural tissues during apoptosis. Retinal photoreceptors undergo apoptosis after retinal detachment....
Hisatomi, Toshio, Sakamoto, Taiji, Murata, Toshinori, Yamanaka, Ichiro, Oshima, Yuji, Hata, Yasuaki, ...
Apoptosis-inducing factor (AIF) is a novel mediator in apoptosis. AIF is a flavoprotein that is normally confined to the mitochondrial intermembrane space, yet translocates to the nucleus in several...
Mitochondrial Cell Death Control in Familial Parkinson Disease
Kroemer, Guido, Blomgren, Klas
Many sporadic cases of Parkinsons disease have mutations in the PINK protein kinase, whose substrate is now revealed to be a protein that protects mitochondria from oxidative stress.
Cytopathic effects of the cytomegalovirus-encoded apoptosis inhibitory protein vMIA
Poncet, Delphine, Pauleau, Anne-Laure, Szabadkai, Gyorgy, Vozza, Angelo, Scholz, Sebastian R., Le Bras, Morgane, ...
Replication of human cytomegalovirus (CMV) requires the expression of the viral mitochondria–localized inhibitor of apoptosis (vMIA). vMIA inhibits apoptosis by recruiting Bax to mitochondria,...
Why yeast cells can undergo apoptosis: death in times of peace, love, and war
Büttner, Sabrina, Eisenberg, Tobias, Herker, Eva, Carmona-Gutierrez, Didac, Kroemer, Guido, Madeo, Frank
The purpose of apoptosis in multicellular organisms is obvious: single cells die for the benefit of the whole organism (for example, during tissue development or embryogenesis). Although apoptosis...
Molecular mechanisms of sulfasalazine-induced T-cell apoptosis
Liptay, Susanne, Fulda, Simone, Schanbacher, Marta, Bourteele, Soizic, Ferri, Karine F, Kroemer, Guido, ...
Impaired apoptosis of T-lymphocytes is involved in the development of chronic inflammatory disorders. Previously we have shown that the anti-inflammatory drug sulfasalazine induces apoptosis in a...
Zhu, Changlian, Wang, Xiaoyang, Deinum, Johanna, Huang, Zhiheng, Gao, Jianfeng, Modjtahedi, Nazanine, ...
Upon cerebral hypoxia-ischemia (HI), apoptosis-inducing factor (AIF) can move from mitochondria to nuclei, participate in chromatinolysis, and contribute to the execution of cell death. Previous work...
Inhibition of Chk1 Kills Tetraploid Tumor Cells through a p53-Dependent Pathway
Vitale, Ilio, Galluzzi, Lorenzo, Vivet, Sonia, Nanty, Lisa, Dessen, Philippe, Senovilla, Laura, ...
Tetraploidy constitutes an adaptation to stress and an intermediate step between euploidy and aneuploidy in oncogenesis. Tetraploid cells are particularly resistant against genotoxic stress including...
An AIF orthologue regulates apoptosis in yeast
Wissing, Silke, Ludovico, Paula, Herker, Eva, Büttner, Sabrina, Engelhardt, Silvia M., Decker, Thorsten, ...
Apoptosis-inducing factor (AIF), a key regulator of cell death, is essential for normal mammalian development and participates in pathological apoptosis. The proapoptotic nature of AIF and its mode...
Essential role of p53 phosphorylation by p38 MAPK in apoptosis induction by the HIV-1 envelope
Perfettini, Jean-Luc, Castedo, Maria, Nardacci, Roberta, Ciccosanti, Fabiola, Boya, Patricia, Roumier, Thomas, ...
The proapoptotic activity of the transcription factor p53 critically depends on the phosphorylation of serine 46 (p53S46P). Here, we show that syncytia containing p53S46P could be detected in lymph...
Caspase-dependent immunogenicity of doxorubicin-induced tumor cell death
Casares, Noelia, Pequignot, Marie O., Tesniere, Antoine, Ghiringhelli, François, Roux, Stéphan, Chaput, Nathalie, ...
Systemic anticancer chemotherapy is immunosuppressive and mostly induces nonimmunogenic tumor cell death. Here, we show that even in the absence of any adjuvant, tumor cells dying in response to...
Ghiringhelli, François, Puig, Pierre E., Roux, Stephan, Parcellier, Arnaud, Schmitt, Elise, Solary, Eric, ...
The mechanisms through which regulatory T cells accumulate in lymphoid organs of tumor-bearing hosts remain elusive. Our experiments indicate that the accumulation of CD4+CD25+ regulatory T cells (T...
Perfettini, Jean-Luc, Roumier, Thomas, Castedo, Maria, Larochette, Nathanael, Boya, Patricia, Raynal, Brigitte, ...
The coculture of cells expressing the HIV-1 envelope glycoprotein complex (Env) with cells expressing CD4 results into cell fusion, deregulated mitosis, and subsequent cell death. Here, we show that...
Developmental Expression of IL-2-Receptor Light Chain (CD25) in the Chicken Embryo
Fedecka-Bruner, Barbara, Penninger, Josef, Vaigot, Pierre, Lehmann, Anne, Martínez-A., Carlos, Kroemer, Guido
Thymocyte differentiation obeys the same fundamental principles in mammals as in avian species. This parallelism does not only affect the developmentally controlled acquisition of CD3, 4, 8, and TcR...
T-Lymphocyte Subsets in the Embryonic Spleen Undergoing a Graft-Versus-Host Reaction
Fedecka-Bruner, Barbara, Vaigot, Pierre, Désveaux-Chabrol, Jacqueline, Gendreau, Marcelle, Kroemer, Guido, Dieterlen-Lièvre, Françoise
Allogeneic immunocompetent T cells injected into chicken embryos induce a graft-versushost reaction (GVHR) whose most prominent manifestation is splenic hyperplasia. The highly inbred CC and CB...
Mitochondrial Release of Caspase-2 and -9 during the Apoptotic Process
Susin, Santos A., Lorenzo, Hans K., Zamzami, Naoufal, Marzo, Isabel, Brenner, Catherine, Larochette, Nathanael, ...
The barrier function of mitochondrial membranes is perturbed early during the apoptotic process. Here we show that the mitochondria contain a caspase-like enzymatic activity cleaving the caspase...
Two Distinct Pathways Leading to Nuclear Apoptosis
Susin, Santos A., Daugas, Eric, Ravagnan, Luigi, Samejima, Kumiko, Zamzami, Naoufal, Loeffler, Markus, ...
Apaf-1−/− or caspase-3−/− cells treated with a variety of apoptosis inducers manifest apoptosis-associated alterations including the translocation of apoptosis-inducing factor (AIF) from...
Castedo, Maria, Ferri, Karine F., Blanco, Julià, Roumier, Thomas, Larochette, Nathanael, Barretina, Jordi, ...
Syncytia arising from the fusion of cells expressing a lymphotropic human immunodeficiency virus (HIV)-1–encoded envelope glycoprotein complex (Env) gene with cells expressing the CD4/CXCR4 complex...
Jacotot, Etienne, Ravagnan, Luigi, Loeffler, Markus, Ferri, Karine F., Vieira, Helena L.A., Zamzami, Naoufal, ...
Viral protein R (Vpr) encoded by HIV-1 is a facultative inducer of apoptosis. When added to intact cells or purified mitochondria, micromolar and submicromolar doses of synthetic Vpr cause a rapid...
Ferri, Karine F., Jacotot, Etienne, Blanco, Julià, Esté, José A., Zamzami, Naoufal, Susin, Santos A., ...
Syncytia arising from the fusion of cells expressing a lymphotropic HIV type 1–encoded envelope glycoprotein complex (Env) with cells expressing the CD4/CXC chemokine receptor 4 complex...
Jacotot, Etienne, Ferri, Karine F., El Hamel, Chahrazed, Brenner, Catherine, Druillennec, Sabine, Hoebeke, Johan, ...
Viral protein R (Vpr), an apoptogenic accessory protein encoded by HIV-1, induces mitochondrial membrane permeabilization (MMP) via a specific interaction with the permeability transition pore...
Susin, Santos A., Zamzami, Naoufal, Castedo, Maria, Daugas, Eric, Wang, Hong-Gang, Geley, Stephan, ...
According to current understanding, cytoplasmic events including activation of protease cascades and mitochondrial permeability transition (PT) participate in the control of nuclear apoptosis....
Marzo, Isabel, Brenner, Catherine, Zamzami, Naoufal, Susin, Santos A., Beutner, Gisela, Brdiczka, Dieter, ...
Early in programmed cell death (apoptosis), mitochondrial membrane permeability increases. This is at least in part due to opening of the permeability transition (PT) pore, a multiprotein complex...
Lysosomal Membrane Permeabilization Induces Cell Death in a Mitochondrion-dependent Fashion
Boya, Patricia, Andreau, Karine, Poncet, Delphine, Zamzami, Naoufal, Perfettini, Jean-Luc, Metivier, Didier, ...
A number of diseases are due to lysosomal destabilization, which results in damaging cell loss. To investigate the mechanisms of lysosomal cell death, we characterized the cytotoxic action of two...
Apoptosis-inducing factor is involved in the regulation of caspase-independent neuronal cell death
Cregan, Sean P., Fortin, Andre, MacLaurin, Jason G., Callaghan, Steven M., Cecconi, Francesco, Yu, Seong-Woon, ...
Caspase-independent death mechanisms have been shown to execute apoptosis in many types of neuronal injury. P53 has been identified as a key regulator of neuronal cell death after acute injury such...
Functional and physical interaction between Bcl-XL and a BH3-like domain in Beclin-1
Maiuri, M Chiara, Le Toumelin, Gaëtane, Criollo, Alfredo, Rain, Jean-Christophe, Gautier, Fabien, Juin, Philippe, ...
The anti-apoptotic proteins Bcl-2 and Bcl-XL bind and inhibit Beclin-1, an essential mediator of autophagy. Here, we demonstrate that this interaction involves a BH3 domain within Beclin-1 (residues...
Viral Control of Mitochondrial Apoptosis
Galluzzi, Lorenzo, Brenner, Catherine, Morselli, Eugenia, Touat, Zahia, Kroemer, Guido
Throughout the process of pathogen–host co-evolution, viruses have developed a battery of distinct strategies to overcome biochemical and immunological defenses of the host. Thus, viruses have...