Functional Coordination of Three Mitotic Motors in Drosophila EmbryosV⃞
Sharp, David J., Brown, Heather M., Kwon, Mijung, Rogers, Gregory C., Holland, Gina, Scholey, Jonathan M.
It is well established that multiple microtubule-based motors contribute to the formation and function of the mitotic spindle, but how the activities of these motors interrelate remains unclear. Here...
Kwon, Mijung, Morales-Mulia, Sandra, Brust-Mascher, Ingrid, Rogers, Gregory C., Sharp, David J., Scholey, Jonathan M.
Mitosis requires the concerted activities of multiple microtubule (MT)-based motor proteins. Here we examined the contribution of the chromokinesin, KLP3A, to mitotic spindle morphogenesis and...
Functional Coordination of Three Mitotic Motors in Drosophila EmbryosV⃞
Sharp, David J., Brown, Heather M., Kwon, Mijung, Rogers, Gregory C., Holland, Gina, Scholey, Jonathan M.
It is well established that multiple microtubule-based motors contribute to the formation and function of the mitotic spindle, but how the activities of these motors interrelate remains unclear. Here...
Kwon, Mijung, Morales-Mulia, Sandra, Brust-Mascher, Ingrid, Rogers, Gregory C., Sharp, David J., Scholey, Jonathan M.
Mitosis requires the concerted activities of multiple microtubule (MT)-based motor proteins. Here we examined the contribution of the chromokinesin, KLP3A, to mitotic spindle morphogenesis and...
Microtubule binding by dynactin is required for microtubule organization but not cargo transport
Kim, Hwajin, Ling, Shuo-Chien, Rogers, Gregory C., Kural, Comert, Selvin, Paul R., Rogers, Stephen L., ...
Dynactin links cytoplasmic dynein and other motors to cargo and is involved in organizing radial microtubule arrays. The largest subunit of dynactin, p150glued, binds the dynein intermediate chain...
Three microtubule severing enzymes contribute to the “Pacman-flux” machinery that moves chromosomes
Zhang, Dong, Rogers, Gregory C., Buster, Daniel W., Sharp, David J.
Chromosomes move toward mitotic spindle poles by a Pacman-flux mechanism linked to microtubule depolymerization: chromosomes actively depolymerize attached microtubule plus ends (Pacman) while being...
Mitosis, microtubules, and the matrix
Scholey, Jonathan M., Rogers, Gregory C., Sharp, David J.
The mechanical events of mitosis depend on the action of microtubules and mitotic motors, but whether these spindle components act alone or in concert with a spindle matrix is an important question.
Drosophila EB1 is important for proper assembly, dynamics, and positioning of the mitotic spindle
Rogers, Stephen L., Rogers, Gregory C., Sharp, David J., Vale, Ronald D.
EB1 is an evolutionarily conserved protein that localizes to the plus ends of growing microtubules. In yeast, the EB1 homologue (BIM1) has been shown to modulate microtubule dynamics and link...
Rogers, Gregory C., Chui, Kitty K., Lee, Edwin W., Wedaman, Karen P., Sharp, David J., Holland, Gina, ...
We have investigated the intracellular roles of an Xklp2-related kinesin motor, KRP180, in positioning spindle poles during early sea urchin embryonic cell division using quantitative, real-time...
Rogers, Gregory C., Rusan, Nasser M., Peifer, Mark, Rogers, Stephen L.
In animal cells, centrosomes nucleate microtubules that form polarized arrays to organize the cytoplasm. Drosophila presents an interesting paradox however, as centrosome-deficient mutant animals...