Membrane-anchored Plakoglobins Have Multiple Mechanisms of Action in Wnt Signaling
Klymkowsky, Michael W., Williams, Bart O., Barish, Grant D., Varmus, Harold E., Vourgourakis, Yanni E.
In Wnt signaling, β-catenin and plakoglobin transduce signals to the nucleus through interactions with TCF-type transcription factors. However, when plakoglobin is artificially engineered to...
Pregnane X receptor prevents hepatorenal toxicity from cholesterol metabolites
Sonoda, Junichiro, Chong, Ling Wa, Downes, Michael, Barish, Grant D., Coulter, Sally, Liddle, Christopher, ...
Efficient detoxification and clearance of cholesterol metabolites such as oxysterols, bile alcohols, and bile acids are critical for survival because they can promote liver and cardiovascular...
PPARδ: a dagger in the heart of the metabolic syndrome
Barish, Grant D., Narkar, Vihang A., Evans, Ronald M.
Obesity is a growing threat to global health by virtue of its association with insulin resistance, glucose intolerance, hypertension, and dyslipidemia, collectively known as the metabolic syndrome or...
Membrane-anchored Plakoglobins Have Multiple Mechanisms of Action in Wnt Signaling
Klymkowsky, Michael W., Williams, Bart O., Barish, Grant D., Varmus, Harold E., Vourgourakis, Yanni E.
In Wnt signaling, β-catenin and plakoglobin transduce signals to the nucleus through interactions with TCF-type transcription factors. However, when plakoglobin is artificially engineered to...
Pregnane X receptor prevents hepatorenal toxicity from cholesterol metabolites
Sonoda, Junichiro, Chong, Ling Wa, Downes, Michael, Barish, Grant D., Coulter, Sally, Liddle, Christopher, ...
Efficient detoxification and clearance of cholesterol metabolites such as oxysterols, bile alcohols, and bile acids are critical for survival because they can promote liver and cardiovascular...
PPARδ: a dagger in the heart of the metabolic syndrome
Barish, Grant D., Narkar, Vihang A., Evans, Ronald M.
Obesity is a growing threat to global health by virtue of its association with insulin resistance, glucose intolerance, hypertension, and dyslipidemia, collectively known as the metabolic syndrome or...
Nuclear receptor ERRα and coactivator PGC-1β are effectors of IFN-γ-induced host defense
Sonoda, Junichiro, Laganière, Josée, Mehl, Isaac R., Barish, Grant D., Chong, Ling-Wa, Li, Xiangli, ...
Macrophage activation by the proinflammatory cytokine interferon-γ (IFN-γ) is a critical component of the host innate response to bacterial pathogenesis. However, the precise nature of the...
PPARδ regulates multiple proinflammatory pathways to suppress atherosclerosis
Barish, Grant D., Atkins, Annette R., Downes, Michael, Olson, Peter, Chong, Ling-Wa, Nelson, Mike, ...
Lipid homeostasis and inflammation are key determinants in atherogenesis, exemplified by the requirement of lipid-laden, foam cell macrophages for atherosclerotic lesion formation. Although the...
PPARδ-mediated antiinflammatory mechanisms inhibit angiotensin II-accelerated atherosclerosis
Takata, Yasunori, Liu, Joey, Yin, Fen, Collins, Alan R., Lyon, Christopher J., Lee, Chih-Hao, ...
Activation of the nuclear hormone receptor peroxisome proliferator-activated receptor δ (PPARδ) has been shown to improve insulin resistance, adiposity, and plasma HDL levels. However, its...