Gottfried Schatz

How proteins are transported into mitochondria (1981)

Neupert, Walter, Schatz, Gottfried

Most mitochondrial polypeptides are synthesized outside the organelle as precursors which are usually larger than the ‘mature’ polypeptides found within mitochondria. The precursors are imported...

Domain structure and lipid interaction of recombinant yeast Tim44

Weiss, Celeste, Oppliger, Wolfgang, Vergères, Guy, Demel, Rudy, Jenö, Paul, Horst, Martin, ...

Tim44 is an essential component of the machinery that mediates the translocation of nuclear-encoded proteins across the mitochondrial inner membrane. It functions as a membrane anchor for the...

Mitochondrial Lon of Saccharomyces cerevisiae is a ring-shaped protease with seven flexible subunits

Stahlberg, Henning, Kutejová, Eva, Suda, Kitaru, Wolpensinger, Bettina, Lustig, Ariel, Schatz, Gottfried, ...

Lon (or La) is a soluble, homooligomeric ATP-dependent protease. Mass determination and cryoelectron microscopy of pure mitochondrial Lon from Saccharomyces cerevisiae identify Lon as a flexible...

Human deafness dystonia syndrome is a mitochondrial disease

Koehler, Carla M., Leuenberger, Danielle, Merchant, Sabeeha, Renold, Anja, Junne, Tina, Schatz, Gottfried

The human deafness dystonia syndrome results from the mutation of a protein (DDP) of unknown function. We show now that DDP is a mitochondrial protein and similar to five small proteins (Tim8p,...

The ATPase and protease domains of yeast mitochondrial Lon: Roles in proteolysis and respiration-dependent growth

Van Dijl, Jan Maarten, Kutejová, Eva, Suda, Kitaru, Perečko, Dušan, Schatz, Gottfried, Suzuki, Carolyn K.

The ATP-dependent Lon protease of Saccharomyces cerevisiae mitochondria is required for selective proteolysis in the matrix, maintenance of mitochondrial DNA, and respiration-dependent growth. Lon...

Tim18p, a New Subunit of the TIM22 Complex That Mediates Insertion of Imported Proteins into the Yeast Mitochondrial Inner Membrane

Koehler, Carla M., Murphy, Michael P., Bally, Nikolaus A., Leuenberger, Danielle, Oppliger, Wolfgang, Dolfini, Luisita, ...

Import of carrier proteins from the cytoplasm into the mitochondrial inner membrane of yeast is mediated by a distinct system consisting of two soluble 70-kDa protein complexes in the intermembrane...

Biosynthesis and assembly of the proton-translocating adenosine triphosphatase complex from chloroplasts

Nelson, Nathan, Nelson, Hannah, Schatz, Gottfried

The H+-translocating ATPase complex of chloroplasts consists of at least eight nonidentical subunits. Five of these (α, β, γ, δ, and ε subunits) collectively constitute the globular...

The outer membrane of yeast mitochondria: isolation of outside-out sealed vesicles

Riezman, Howard, Hay, Rick, Gasser, Susan, Daum, Günther, Schneider, Greti, Witte, Christine, ...

The yeast mitochondrial outer membrane was isolated and 10 of its major polypeptides were identified (mol. wts. 109, 70, 57, 45, 45, 42, 33, 29, 25 and 14 kd). The membrane has no major polypeptide...

Yeast mitochondrial outer membrane specifically binds cytoplasmically-synthesized precursors of mitochondrial proteins

Riezman, Howard, Hay, Rick, Witte, Christine, Nelson, Nathan, Schatz, Gottfried

The precursor of cytochrome b2 (a cytoplasmically-synthesized mitochondrial protein) binds to isolated mitochondria or to isolated outer membrane vesicles. Binding does not require an energized inner...

The cleavable pre-sequence of an imported chloroplast protein directs attached polypeptides into yeast mitochondria

Hurt, Eduard C., Soltanifar, Nouchine, Goldschmidt-Clermont, Michel, Rochaix, Jean-David, Schatz, Gottfried

The cleavable pre-sequences of imported chloroplast and mitochondrial proteins have several features in common. This structural similarity prompted us to test whether a chloroplast pre-sequence...

Domain structure and lipid interaction of recombinant yeast Tim44

Weiss, Celeste, Oppliger, Wolfgang, Vergères, Guy, Demel, Rudy, Jenö, Paul, Horst, Martin, ...

Tim44 is an essential component of the machinery that mediates the translocation of nuclear-encoded proteins across the mitochondrial inner membrane. It functions as a membrane anchor for the...

Mitochondrial Lon of Saccharomyces cerevisiae is a ring-shaped protease with seven flexible subunits

Stahlberg, Henning, Kutejová, Eva, Suda, Kitaru, Wolpensinger, Bettina, Lustig, Ariel, Schatz, Gottfried, ...

Lon (or La) is a soluble, homooligomeric ATP-dependent protease. Mass determination and cryoelectron microscopy of pure mitochondrial Lon from Saccharomyces cerevisiae identify Lon as a flexible...

Human deafness dystonia syndrome is a mitochondrial disease

Koehler, Carla M., Leuenberger, Danielle, Merchant, Sabeeha, Renold, Anja, Junne, Tina, Schatz, Gottfried

The human deafness dystonia syndrome results from the mutation of a protein (DDP) of unknown function. We show now that DDP is a mitochondrial protein and similar to five small proteins (Tim8p,...

The ATPase and protease domains of yeast mitochondrial Lon: Roles in proteolysis and respiration-dependent growth

Van Dijl, Jan Maarten, Kutejová, Eva, Suda, Kitaru, Perečko, Dušan, Schatz, Gottfried, Suzuki, Carolyn K.

The ATP-dependent Lon protease of Saccharomyces cerevisiae mitochondria is required for selective proteolysis in the matrix, maintenance of mitochondrial DNA, and respiration-dependent growth. Lon...

Tim18p, a New Subunit of the TIM22 Complex That Mediates Insertion of Imported Proteins into the Yeast Mitochondrial Inner Membrane

Koehler, Carla M., Murphy, Michael P., Bally, Nikolaus A., Leuenberger, Danielle, Oppliger, Wolfgang, Dolfini, Luisita, ...

Import of carrier proteins from the cytoplasm into the mitochondrial inner membrane of yeast is mediated by a distinct system consisting of two soluble 70-kDa protein complexes in the intermembrane...

Biosynthesis and assembly of the proton-translocating adenosine triphosphatase complex from chloroplasts

Nelson, Nathan, Nelson, Hannah, Schatz, Gottfried

The H+-translocating ATPase complex of chloroplasts consists of at least eight nonidentical subunits. Five of these (α, β, γ, δ, and ε subunits) collectively constitute the globular...

The outer membrane of yeast mitochondria: isolation of outside-out sealed vesicles

Riezman, Howard, Hay, Rick, Gasser, Susan, Daum, Günther, Schneider, Greti, Witte, Christine, ...

The yeast mitochondrial outer membrane was isolated and 10 of its major polypeptides were identified (mol. wts. 109, 70, 57, 45, 45, 42, 33, 29, 25 and 14 kd). The membrane has no major polypeptide...

Yeast mitochondrial outer membrane specifically binds cytoplasmically-synthesized precursors of mitochondrial proteins

Riezman, Howard, Hay, Rick, Witte, Christine, Nelson, Nathan, Schatz, Gottfried

The precursor of cytochrome b2 (a cytoplasmically-synthesized mitochondrial protein) binds to isolated mitochondria or to isolated outer membrane vesicles. Binding does not require an energized inner...

The cleavable pre-sequence of an imported chloroplast protein directs attached polypeptides into yeast mitochondria

Hurt, Eduard C., Soltanifar, Nouchine, Goldschmidt-Clermont, Michel, Rochaix, Jean-David, Schatz, Gottfried

The cleavable pre-sequences of imported chloroplast and mitochondrial proteins have several features in common. This structural similarity prompted us to test whether a chloroplast pre-sequence...