Gota Kawai

Inhibition of Human Immunodeficiency Virus Type 1 Activity In Vitro by a New Self-Stabilized Oligonucleotide with Guanosine-Thymidine Quadruplex Motifs

Suzuki, Jun-ichiro, Miyano-Kurosaki, Naoko, Kuwasaki, Tomoyuki, Takeuchi, Hiroaki, Kawai, Gota, Takaku, Hiroshi

An oligonucleotide with a dimeric hairpin guanosine quadruplex (basket type structure) (dG3T4G3-s), containing phosphorothioate groups, was able to inhibit human immunodeficiency virus type 1...

NMR structures of double loops of an RNA aptamer against mammalian initiation factor 4A

Sakamoto, Taiichi, Oguro, Akihiro, Kawai, Gota, Ohtsu, Takashi, Nakamura, Yoshikazu

A high affinity RNA aptamer (APT58, 58 nt long) against mammalian initiation factor 4A (eIF4A) requires nearly its entire nucleotide sequence for efficient binding. Since splitting either APT58 or...

Solution structure of an RNA fragment with the P7/P9.0 region and the 3'-terminal guanosine of the tetrahymena group I intron.

Kitamura, Aya, Muto, Yutaka, Watanabe, Satoru, Kim, Insil, Ito, Takuhiro, Nishiya, Yoichi, ...

In the second step of the two consecutive transesterifications of the self-splicing reaction of the group I intron, the conserved guanosine at the 3' terminus of the intron (omegaG) binds to the...

Solution structure of an RNA stem–loop derived from the 3′ conserved region of eel LINE UnaL2

BABA, SEIKI, KAJIKAWA, MASAKI, OKADA, NORIHIRO, KAWAI, GOTA

The eel long interspersed element (LINE) UnaL2 and its partner short interspersed element (SINE) share a conserved 3′ tail containing a stem–loop that is critical for their retrotransposition....

Solution structure and functional importance of a conserved RNA hairpin of eel LINE UnaL2

Nomura, Yusuke, Kajikawa, Masaki, Baba, Seiki, Nakazato, Shinta, Imai, Takayuki, Sakamoto, Taiichi, ...

The eel long interspersed element (LINE) UnaL2 and its partner short interspersed element (SINE) share a conserved 3′ tail that is critical for their retrotransposition. The predicted secondary...

Inhibition of Human Immunodeficiency Virus Type 1 Activity In Vitro by a New Self-Stabilized Oligonucleotide with Guanosine-Thymidine Quadruplex Motifs

Suzuki, Jun-ichiro, Miyano-Kurosaki, Naoko, Kuwasaki, Tomoyuki, Takeuchi, Hiroaki, Kawai, Gota, Takaku, Hiroshi

An oligonucleotide with a dimeric hairpin guanosine quadruplex (basket type structure) (dG3T4G3-s), containing phosphorothioate groups, was able to inhibit human immunodeficiency virus type 1...

NMR structures of double loops of an RNA aptamer against mammalian initiation factor 4A

Sakamoto, Taiichi, Oguro, Akihiro, Kawai, Gota, Ohtsu, Takashi, Nakamura, Yoshikazu

A high affinity RNA aptamer (APT58, 58 nt long) against mammalian initiation factor 4A (eIF4A) requires nearly its entire nucleotide sequence for efficient binding. Since splitting either APT58 or...

Solution structure of an RNA fragment with the P7/P9.0 region and the 3'-terminal guanosine of the tetrahymena group I intron.

Kitamura, Aya, Muto, Yutaka, Watanabe, Satoru, Kim, Insil, Ito, Takuhiro, Nishiya, Yoichi, ...

In the second step of the two consecutive transesterifications of the self-splicing reaction of the group I intron, the conserved guanosine at the 3' terminus of the intron (omegaG) binds to the...

Solution structure of an RNA stem–loop derived from the 3′ conserved region of eel LINE UnaL2

BABA, SEIKI, KAJIKAWA, MASAKI, OKADA, NORIHIRO, KAWAI, GOTA

The eel long interspersed element (LINE) UnaL2 and its partner short interspersed element (SINE) share a conserved 3′ tail containing a stem–loop that is critical for their retrotransposition....

Solution structure and functional importance of a conserved RNA hairpin of eel LINE UnaL2

Nomura, Yusuke, Kajikawa, Masaki, Baba, Seiki, Nakazato, Shinta, Imai, Takayuki, Sakamoto, Taiichi, ...

The eel long interspersed element (LINE) UnaL2 and its partner short interspersed element (SINE) share a conserved 3′ tail that is critical for their retrotransposition. The predicted secondary...

Prediction of RNA Pseudoknots Using Heuristic Modeling with Mapping and Sequential Folding

Dawson, Wayne K., Fujiwara, Kazuya, Kawai, Gota

Predicting RNA secondary structure is often the first step to determining the structure of RNA. Prediction approaches have historically avoided searching for pseudoknots because of the extreme...