Gerrit J. K. Praefcke

Structural basis for binding of accessory proteins by the appendage domain of GGAs (2003)

Collins, Brett M., Praefcke, Gerrit J. K., Robinson, Margaret S., Owen, David J.

The Golgi-associated, gamma-adaptin-related, ADP-ribosylation- factor binding proteins ( GGAs) and adaptor protein (AP)-1 are adaptors involved in clathrin-mediated transport between the trans-Golgi...

Das humane Guanylat-bindende Protein 1 : Modell oder Sonderfall der Dynamin-verwandten GTP-bindenden Proteine (2001)

Praefcke, Gerrit J. K.

Ziel der Arbeit war die Aufklärung des Mechanismus der Hydrolyse von GTP durch das humane Guanylat-bindende Protein 1 (hGBP1). Die Hydrolyse von GTP zu GMP erfolgt unter sequentieller Abspaltung der...

Triphosphate structure of guanylate-binding protein 1 and implications for nucleotide binding and GTPase mechanism

Prakash, Balaji, Renault, Louis, Praefcke, Gerrit J.K., Herrmann, Christian, Wittinghofer, Alfred

The interferon-γ-induced guanylate-binding protein 1 (GBP1) belongs to a special class of large GTP- binding proteins of 60–100 kDa with unique characteristics. Here we present the structure of...

Evolving nature of the AP2 α-appendage hub during clathrin-coated vesicle endocytosis

Praefcke, Gerrit J K, Ford, Marijn G J, Schmid, Eva M, Olesen, Lene E, Gallop, Jennifer L, Peak-Chew, Sew-Yeu, ...

Clathrin-mediated endocytosis involves the assembly of a network of proteins that select cargo, modify membrane shape and drive invagination, vesicle scission and uncoating. This network is initially...

Role of the AP2 β-Appendage Hub in Recruiting Partners for Clathrin-Coated Vesicle Assembly

Schmid, Eva M, Ford, Marijn G. J, Burtey, Anne, Praefcke, Gerrit J. K, Peak-Chew, Sew-Yeu, Mills, Ian G, ...

Adaptor protein complex 2 α and β-appendage domains act as hubs for the assembly of accessory protein networks involved in clathrin-coated vesicle formation. We identify a large repertoire of...

Triphosphate structure of guanylate-binding protein 1 and implications for nucleotide binding and GTPase mechanism

Prakash, Balaji, Renault, Louis, Praefcke, Gerrit J.K., Herrmann, Christian, Wittinghofer, Alfred

The interferon-γ-induced guanylate-binding protein 1 (GBP1) belongs to a special class of large GTP- binding proteins of 60–100 kDa with unique characteristics. Here we present the structure of...

Evolving nature of the AP2 α-appendage hub during clathrin-coated vesicle endocytosis

Praefcke, Gerrit J K, Ford, Marijn G J, Schmid, Eva M, Olesen, Lene E, Gallop, Jennifer L, Peak-Chew, Sew-Yeu, ...

Clathrin-mediated endocytosis involves the assembly of a network of proteins that select cargo, modify membrane shape and drive invagination, vesicle scission and uncoating. This network is initially...

Role of the AP2 β-Appendage Hub in Recruiting Partners for Clathrin-Coated Vesicle Assembly

Schmid, Eva M, Ford, Marijn G. J, Burtey, Anne, Praefcke, Gerrit J. K, Peak-Chew, Sew-Yeu, Mills, Ian G, ...

Adaptor protein complex 2 α and β-appendage domains act as hubs for the assembly of accessory protein networks involved in clathrin-coated vesicle formation. We identify a large repertoire of...

EpsinR: an AP1/clathrin interacting protein involved in vesicle trafficking

Mills, Ian G., Praefcke, Gerrit J.K., Vallis, Yvonne, Peter, Brian J., Olesen, Lene E., Gallop, Jennifer L., ...

EpsinR is a clathrin-coated vesicle (CCV) enriched 70-kD protein that binds to phosphatidylinositol-4-phosphate, clathrin, and the gamma appendage domain of the adaptor protein complex 1 (AP1). In...