Urodele p53 tolerates amino acid changes found in p53 variants linked to human cancer (2007)
Villiard, Éric, Brinkmann, Henner, Moiseeva, Olga, Mallette, Frédérick A, Ferbeyre, Gerardo, Roy, Stéphane
Abstract Background Urodele amphibians like the axolotl are unique among vertebrates in their ability to regenerate and their resistance to develop cancers. It is unknown whether these traits are...
Amber suppression in Escherichia coli by unusual mitochondria-like transfer RNAs
Bourdeau, Véronique, Steinberg, Sergey V., Ferbeyre, Gerardo, Emond, Rémi, Cermakian, Nicolas, Cedergren, Robert
The “cloverleaf” base-pairing pattern was established as the structural paradigm of active tRNA species some 30 years ago. Nevertheless, this pattern does not accommodate the folding of certain...
Samarsky, Dmitry A., Ferbeyre, Gerardo, Bertrand, Edouard, Singer, Robert H., Cedergren, Robert, Fournier, Maurille J.
A hammerhead ribozyme has been localized to the yeast nucleolus by using the U3 small nucleolar RNA as a carrier. The hybrid small nucleolar RNA:ribozyme, designated a “snorbozyme,” is...
Schistosome Satellite DNA Encodes Active Hammerhead Ribozymes
Ferbeyre, Gerardo, Smith, James M., Cedergren, Robert
Using a computer program designed to search for RNA structural motifs in sequence databases, we have found a hammerhead ribozyme domain encoded in the Smα repetitive DNA of Schistosoma mansoni....
Hammerhead-mediated processing of satellite pDo500 family transcripts from Dolichopoda cave crickets
Rojas, Andres A., Vazquez-Tello, Alejandro, Ferbeyre, Gerardo, Venanzetti, Federica, Bachmann, Lutz, Paquin, Bruno, ...
This work reports the discovery and functional characterization of catalytically active hammerhead motifs within satellite DNA of the pDo500 family from several Dolichopoda cave cricket species. We...
Oncogenic ras and p53 Cooperate To Induce Cellular Senescence
Ferbeyre, Gerardo, De Stanchina, Elisa, Lin, Athena W., Querido, Emmanuelle, McCurrach, Mila E., J. Hannon, Gregory, ...
Oncogenic activation of the mitogen-activated protein (MAP) kinase cascade in murine fibroblasts initiates a senescence-like cell cycle arrest that depends on the ARF/p53 tumor suppressor pathway. To...
Distribution of Hammerhead and Hammerhead-like RNA Motifs Through the GenBank
Ferbeyre, Gerardo, Bourdeau, Véronique, Pageau, Marie, Miramontes, Pedro, Cedergren, Robert
Hammerhead ribozymes previously were found in satellite RNAs from plant viroids and in repetitive DNA from certain species of newts and schistosomes. To determine if this catalytic RNA motif has a...
PML is induced by oncogenic ras and promotes premature senescence
Ferbeyre, Gerardo, De Stanchina, Elisa, Querido, Emmanuelle, Baptiste, Nicole, Prives, Carol, Lowe, Scott W.
Oncogenic ras provokes a senescent-like arrest in human diploid fibroblasts involving the Rb and p53 tumor suppressor pathways. To further characterize this response, we compared gene expression...
E1A signaling to p53 involves the p19ARF tumor suppressor
De Stanchina, Elisa, McCurrach, Mila E., Zindy, Frederique, Shieh, Sheau-Yann, Ferbeyre, Gerardo, Samuelson, Andrew V., ...
The adenovirus E1A oncogene activates p53 through a signaling pathway involving the retinoblastoma protein and the tumor suppressor p19ARF. The ability of E1A to induce p53 and its transcriptional...
DNA Damage Signaling and p53-dependent Senescence after Prolonged β-Interferon StimulationD⃞
Moiseeva, Olga, Mallette, Frédérick A., Mukhopadhyay, Utpal K., Moores, Adrian, Ferbeyre, Gerardo
Interferons are cytokines with potent antiviral and antiproliferative activities. We report that although a transient exposure to β-interferon induces a reversible cell cycle arrest, a sustained...
Amber suppression in Escherichia coli by unusual mitochondria-like transfer RNAs
Bourdeau, Véronique, Steinberg, Sergey V., Ferbeyre, Gerardo, Emond, Rémi, Cermakian, Nicolas, Cedergren, Robert
The “cloverleaf” base-pairing pattern was established as the structural paradigm of active tRNA species some 30 years ago. Nevertheless, this pattern does not accommodate the folding of certain...
Samarsky, Dmitry A., Ferbeyre, Gerardo, Bertrand, Edouard, Singer, Robert H., Cedergren, Robert, Fournier, Maurille J.
A hammerhead ribozyme has been localized to the yeast nucleolus by using the U3 small nucleolar RNA as a carrier. The hybrid small nucleolar RNA:ribozyme, designated a “snorbozyme,” is...
Schistosome Satellite DNA Encodes Active Hammerhead Ribozymes
Ferbeyre, Gerardo, Smith, James M., Cedergren, Robert
Using a computer program designed to search for RNA structural motifs in sequence databases, we have found a hammerhead ribozyme domain encoded in the Smα repetitive DNA of Schistosoma mansoni....
Hammerhead-mediated processing of satellite pDo500 family transcripts from Dolichopoda cave crickets
Rojas, Andres A., Vazquez-Tello, Alejandro, Ferbeyre, Gerardo, Venanzetti, Federica, Bachmann, Lutz, Paquin, Bruno, ...
This work reports the discovery and functional characterization of catalytically active hammerhead motifs within satellite DNA of the pDo500 family from several Dolichopoda cave cricket species. We...
Oncogenic ras and p53 Cooperate To Induce Cellular Senescence
Ferbeyre, Gerardo, De Stanchina, Elisa, Lin, Athena W., Querido, Emmanuelle, McCurrach, Mila E., J. Hannon, Gregory, ...
Oncogenic activation of the mitogen-activated protein (MAP) kinase cascade in murine fibroblasts initiates a senescence-like cell cycle arrest that depends on the ARF/p53 tumor suppressor pathway. To...
Distribution of Hammerhead and Hammerhead-like RNA Motifs Through the GenBank
Ferbeyre, Gerardo, Bourdeau, Véronique, Pageau, Marie, Miramontes, Pedro, Cedergren, Robert
Hammerhead ribozymes previously were found in satellite RNAs from plant viroids and in repetitive DNA from certain species of newts and schistosomes. To determine if this catalytic RNA motif has a...
PML is induced by oncogenic ras and promotes premature senescence
Ferbeyre, Gerardo, De Stanchina, Elisa, Querido, Emmanuelle, Baptiste, Nicole, Prives, Carol, Lowe, Scott W.
Oncogenic ras provokes a senescent-like arrest in human diploid fibroblasts involving the Rb and p53 tumor suppressor pathways. To further characterize this response, we compared gene expression...
E1A signaling to p53 involves the p19ARF tumor suppressor
De Stanchina, Elisa, McCurrach, Mila E., Zindy, Frederique, Shieh, Sheau-Yann, Ferbeyre, Gerardo, Samuelson, Andrew V., ...
The adenovirus E1A oncogene activates p53 through a signaling pathway involving the retinoblastoma protein and the tumor suppressor p19ARF. The ability of E1A to induce p53 and its transcriptional...
DNA Damage Signaling and p53-dependent Senescence after Prolonged β-Interferon StimulationD⃞
Moiseeva, Olga, Mallette, Frédérick A., Mukhopadhyay, Utpal K., Moores, Adrian, Ferbeyre, Gerardo
Interferons are cytokines with potent antiviral and antiproliferative activities. We report that although a transient exposure to β-interferon induces a reversible cell cycle arrest, a sustained...
The DNA damage signaling pathway is a critical mediator of oncogene-induced senescence
Mallette, Frédérick A., Gaumont-Leclerc, Marie-France, Ferbeyre, Gerardo
Here we report that RNA interference against ATM inhibited p53 accumulation in cells expressing oncogenic STAT5 and cooperated with Rb inactivation to suppress STAT5A-induced senescence. Knocking...
Urodele p53 tolerates amino acid changes found in p53 variants linked to human cancer
Villiard, Éric, Brinkmann, Henner, Moiseeva, Olga, Mallette, Frédérick A, Ferbeyre, Gerardo, Roy, Stéphane
Gendron, Karine, Charbonneau, Johanie, Dulude, Dominic, Heveker, Nikolaus, Ferbeyre, Gerardo, Brakier-Gingras, Léa
HIV-1 uses a programmed -1 ribosomal frameshift to synthesize the precursor of its enzymes, Gag-Pol. The frameshift efficiency that is critical for the virus replication, is controlled by an...