George S. Yap

Role of Cytokines in the Formation and Downregulation of Hepatic Circumoval Granulomas and Hepatic Fibrosis in Schistosoma mansoni-Infected Mice (1998)

Allen W Cheever, Dragana Jankovic, George S Yap, Marika C Kullberg, Alan Sher, Thomas A Wynn

Schistosoma mansoni infections are associated with a strong Th2 cytokine response. Treatment of mice with IL-12 or anti-IL-2 or anti-IL-4 before i.v. injection of eggs increased IFNγ production and...

Role of cytokines in the formation and downregulation of hepatic circumoval granulomas and hepatic fibrosis in Schistosoma mansoni-infected mice (1998)

Cheever,Allen W, Jankovic,Dragana, Yap,George S, Kullberg,Marika C, Sher,Alan, Wynn,Thomas A

Schistosoma mansoni infections are associated with a strong Th2 cytokine response. Treatment of mice with IL-12 or anti-IL-2 or anti-IL-4 before i.v. injection of eggs increased IFN-gamma production...

Pathogen-specific loss of host resistance in mice lacking the IFN-γ-inducible gene IGTP

Taylor, Gregory A., Collazo, Carmen M., Yap, George S., Nguyen, Khuong, Gregorio, Theresa A., Taylor, Lynn S., ...

Interferon-γ (IFN-γ) is critical for defense against pathogens, but the molecules that mediate its antimicrobial responses are largely unknown. IGTP is the prototype for a family of...

Partially Protective Vaccination Permits the Development of Latency in a Normally Virulent Strain of Toxoplasma gondii

Yap, George S., Scharton-Kersten, Tanya, Ferguson, David J. P., Howe, Dan, Suzuki, Yasuhiro, Sher, Alan

The virulent RH strain of Toxoplasma gondii is acutely lethal in mice and fails to establish chronic infection. Vaccination of BALB/c mice with a soluble tachyzoite antigen preparation, STAg, in...

The Function of Gamma Interferon-Inducible GTP-Binding Protein IGTP in Host Resistance to Toxoplasma gondii Is Stat1 Dependent and Requires Expression in Both Hematopoietic and Nonhematopoietic Cellular Compartments

Collazo, Carmen M., Yap, George S., Hieny, Sara, Caspar, Patricia, Feng, Carl G., Taylor, Gregory A., ...

IGTP is a member of the 47-kDa family of gamma interferon (IFN-γ)-induced GTPases. We have previously shown that IGTP is critical for host resistance to Toxoplasma gondii infection. In the present...

A natural mutation in the Tyk2 pseudokinase domain underlies altered susceptibility of B10.Q/J mice to infection and autoimmunity

Shaw, Michael H., Boyartchuk, Victor, Wong, Sandy, Karaghiosoff, Marina, Ragimbeau, Josiane, Pellegrini, Sandra, ...

The B10.Q/J strain of mice was serendipitously discovered to be highly susceptible to infection by the intracellular protozoan parasite, Toxoplasma gondii but markedly resistant to induction of...

Rapid Elimination of Toxoplasma gondii by Gamma Interferon-Primed Mouse Macrophages Is Independent of CD40 Signaling▿

Zhao, Yanlin, Wilson, Douglas, Matthews, Suzanne, Yap, George S.

Autophagy has been implicated in the intracellular destruction of Toxoplasma gondii by primed macrophages following gamma interferon (IFN-γ) activation of p47 GTPases. CD40 ligation has also been...

Vacuolar and plasma membrane stripping and autophagic elimination of Toxoplasma gondii in primed effector macrophages

Ling, Yun M., Shaw, Michael H., Ayala, Carol, Coppens, Isabelle, Taylor, Gregory A., Ferguson, David J.P., ...

Apicomplexan protozoan pathogens avoid destruction and establish a replicative niche within host cells by forming a nonfusogenic parasitophorous vacuole (PV). Here we present evidence for...

Effector Cells of Both Nonhemopoietic and Hemopoietic Origin Are Required for Interferon (IFN)-γ– and Tumor Necrosis Factor (TNF)-α–dependent Host Resistance to the Intracellular Pathogen, Toxoplasma gondii

Yap, George S., Sher, Alan

Although interferon (IFN)-γ–activated, mononuclear phagocytes are considered to be the major effectors of resistance to intracellular pathogens, it is unclear how they control the growth of...

Inactivation of Lrg-47 and Irg-47 Reveals a Family of Interferon γ–Inducible Genes with Essential, Pathogen-Specific Roles in Resistance to Infection

Collazo, Carmen M., Yap, George S., Sempowski, Gregory D., Lusby, Kimberly C., Tessarollo, Lino, Woude, George F. Vande, ...

The cytokine interferon (IFN)-γ regulates immune clearance of parasitic, bacterial, and viral infections; however, the underlying mechanisms are poorly understood. Recently, a family of...

A novel role for HMGB1 in TLR9-mediated inflammatory responses to CpG-DNA

Ivanov, Stanimir, Dragoi, Ana-Maria, Wang, Xin, Dallacosta, Corrado, Louten, Jennifer, Musco, Giovanna, ...

CpG-DNA or its synthetic analog CpG-ODN activates innate immunity through Toll-like receptor 9 (TLR9). However, the mechanism of TLR9 activation by CpG-DNA remains elusive. Here we have identified...