Scientific Commons: George R. Uhl

Molecular genetics of nicotine dependence and abstinence: whole genome association using 520,000 SNPs (2007)

Uhl, George R, Liu, Qing-Rong, Drgon, Tomas, Johnson, Catherine, Walther, Donna, Rose, Jed E

Abstract Background Classical genetic studies indicate that nicotine dependence is a substantially heritable complex disorder. Genetic vulnerabilities to nicotine dependence largely overlap with...

Loss of Morphine–induced Suppression of NK Cell activity and T-cell Functions in m-Opioid Receptor Knockout Mice (2006)

Richard J. Weber,, Ricardo Gomez-Flores,, Ichiro Sora,, George R. Uhl

In vivo administration of m mm m-opioid receptor selective agonists to various species is known tosuppress lymphocyte, NK cell, and macrophage functions, in addition to mediate pain relief...

Cocaine reward models: Conditioned place preference can be established in dopamine- and in serotonin-transporter knockout mice

Sora, Ichiro, Wichems, Christine, Takahashi, Nobuyuki, Li, Xiao-Fei, Zeng, Zhizhen, Revay, Randal, ...

Cocaine and methylphenidate block uptake by neuronal plasma membrane transporters for dopamine, serotonin, and norepinephrine. Cocaine also blocks voltage-gated sodium channels, a property not shared...

VMAT2 knockout mice: Heterozygotes display reduced amphetamine-conditioned reward, enhanced amphetamine locomotion, and enhanced MPTP toxicity

Takahashi, Nobuyuki, Miner, Lucinda L., Sora, Ichiro, Ujike, Hiroshi, Revay, Randal S., Kostic, Vladimir, ...

The brain vesicular monoamine transporter (VMAT2) pumps monoamine neurotransmitters and Parkinsonism-inducing dopamine neurotoxins such as 1-methyl-4-phenyl-phenypyridinium (MPP+) from neuronal...

Molecular mechanisms of cocaine reward: Combined dopamine and serotonin transporter knockouts eliminate cocaine place preference

Sora, Ichiro, Hall, F. Scott, Andrews, Anne M., Itokawa, Masanari, Li, Xiao-Fei, Wei, Hong-Bing, ...

Cocaine blocks uptake by neuronal plasma membrane transporters for dopamine (DAT), serotonin (SERT), and norepinephrine (NET). Cocaine reward/reinforcement has been linked to actions at DAT or to...

The μ opiate receptor as a candidate gene for pain: Polymorphisms, variations in expression, nociception, and opiate responses

Uhl, George R., Sora, Ichiro, Wang, Zaijie

There are differences between human individuals and between mouse strains in levels of μ opiate receptor (μOR) expression, responses to painful stimuli, and responses to opiate drugs. One of the...

Genetic analyses of complex behavioral disorders

Uhl, George R., Gold, Lisa H., Risch, Neil

Pooled association genome scanning: Validation and use to identify addiction vulnerability loci in two samples

Liu, Qing-Rong, Drgon, Tomas, Walther, Donna, Johnson, Catherine, Poleskaya, Oxanna, Hess, Judith, ...

Association genome scanning is of increasing interest for identifying the chromosomal regions that contain gene variants that contribute to vulnerability to complex disorders, including addictions....

GBPI, a novel gastrointestinal- and brain-specific PP1-inhibitory protein, is activated by PKC and inactivated by PKA.

Liu, Qing-Rong, Zhang, Ping-Wu, Lin, Zhicheng, Li, Qi-Fu, Woods, Amina S, Troncoso, Juan, ...

The activities of PP1 (protein phosphatase 1), a principal cellular phosphatase that reverses serine/threonine protein phosphorylation, can be altered by inhibitors whose activities are themselves...

Polysubstance Abuse–Vulnerability Genes: Genome Scans for Association, Using 1,004 Subjects and 1,494 Single-Nucleotide Polymorphisms

Uhl, George R., Liu, Qing-Rong, Walther, Donna, Hess, Judith, Naiman, Daniel

Strong genetic contributions to drug abuse vulnerability are well documented, but few chromosomal locations for human drug-abuse vulnerability alleles have been confirmed. We now identify chromosomal...