Gomulski, Ludvik M, Dimopoulos, George, Xi, Zhiyong, Soares, Marcelo B, Bonaldo, Maria F, Malacrida, Anna R, ...
Abstract Background The medfly, Ceratitis capitata , is a highly invasive agricultural pest that has become a model insect for the development of biological control programs. Despite research into...
Aguilar, Ruth, Das, Suchismita, Dong, Yuemei, Dimopoulos, George
Abstract Background Plasmodium infection has been shown to compromise the fitness of the mosquito vector, reducing its fecundity and longevity. However, from an evolutionary perspective, the impact...
Spatial and sex-specific dissection of the Anopheles gambiaemidgut transcriptome (2007)
Warr, Emma, Aguilar, Ruth, Dong, Yuemei, Mahairaki, Vassiliki, Dimopoulos, George
Abstract Background The midgut of hematophagous insects, such as disease transmitting mosquitoes, carries out a variety of essential functions that mostly relate to blood feeding. The midgut of the...
Yuemei Dong, Harry E. Taylor, George Dimopoulos
AgDscam has 101 exons that can produce more than 31,000 potential alternative splice forms. Specific splice forms produced in response to infection by a given pathogen contribute to the mosquito's...
Yuemei Dong, Harry E. Taylor, George Dimopoulos
Activation of the insect innate immune system is dependent on a limited number of pattern recognition receptors (PRRs) capable of interacting with pathogen-associated molecular pattern. Here we...
Anopheles gambiae Immune Responses to Human and Rodent Plasmodium Parasite Species (2006)
Yuemei Dong, Ruth Aguilar, Zhiyong Xi, Emma Warr, Emmanuel Mongin, George Dimopoulos
Transmission of malaria is dependent on the successful completion of the Plasmodium lifecycle in the Anopheles vector. Major obstacles are encountered in the midgut tissue, where most parasites are...
Georgopoulos, Dimitris, Matamis, Dimitris, Routsi, Christina, Michalopoulos, Argiris, Maggina, Nina, Dimopoulos, George, ...
Abstract Introduction The aim of this study was to assess the efficacy of two dosing schedules of recombinant human erythropoietin (rHuEPO) in increasing haematocrit (Hct) and haemoglobin (Hb) and...
Thesis (M.Com.)--Nelson Mandela Metropolitan University, 2005.
Amygdalou, Argyro, Dimopoulos, George, Moukas, Markos, Katsanos, Christos, Katagi, Athina, Mandragos, Costas, ...
Abstract Introduction Tracheotomy is widely performed in the intensive care unit after long-term oral intubation. The present study investigates the immediate influence of tracheotomy on respiratory...
Shen, Zhicheng, Dimopoulos, George, Kafatos, Fotis C., Jacobs-Lorena, Marcelo
An invertebrate intestinal mucin gene, AgMuc1, was isolated from the malaria vector mosquito Anopheles gambiae. The predicted 122-residue protein consists of a central core of seven repeating TTTTVAP...
Heat pipes applied to flat plate solar collectors (1985)
Typescript (photocopy) Includes bibliographical references.
Arcà, Bruno, Lombardo, Fabrizio, De Lara Capurro, Margareth, Della Torre, Alessandra, Dimopoulos, George, James, Anthony A., ...
The signal sequence trap method was used to isolate cDNAs corresponding to proteins containing secretory leader peptides and whose genes are expressed specifically in the salivary glands of the...
Dimopoulos, George, Casavant, Thomas L., Chang, Shereen, Scheetz, Todd, Roberts, Chad, Donohue, Micca, ...
Together with AIDS and tuberculosis, malaria is at the top of the list of devastating infectious diseases. However, molecular genetic studies of its major vector, Anopheles gambiae, are still quite...
A cell surface mucin specifically expressed in the midgut of the malaria mosquito Anopheles gambiae
Shen, Zhicheng, Dimopoulos, George, Kafatos, Fotis C., Jacobs-Lorena, Marcelo
An invertebrate intestinal mucin gene, AgMuc1, was isolated from the malaria vector mosquito Anopheles gambiae. The predicted 122-residue protein consists of a central core of seven repeating TTTTVAP...
Molecular immune responses of the mosquito Anopheles gambiae to bacteria and malaria parasites
Dimopoulos, George, Richman, Adam, Müller, Hans-Michael, Kafatos, Fotis C.
Immune responses of the malaria vector mosquito Anopheles gambiae were monitored systematically by the induced expression of five RNA markers after infection challenge. One newly isolated marker...
Dimopoulos, George, Richman, Adam, Della Torre, Alessandra, Kafatos, Fotis C., Louis, Christos
The isolation and study of Anopheles gambiae genes that are differentially expressed in development, notably in tissues associated with the maturation and transmission of the malaria parasite, is...
Gambicin: A novel immune responsive antimicrobial peptide from the malaria vector Anopheles gambiae
Vizioli, Jacopo, Bulet, Philippe, Hoffmann, Jules A., Kafatos, Fotis C., Müller, Hans-Michael, Dimopoulos, George
A novel mosquito antimicrobial peptide, gambicin, and the corresponding gene were isolated in parallel through differential display-PCR, an expressed sequence tag (EST) project, and characterization...
Dimopoulos, George, Christophides, George K., Meister, Stephan, Schultz, Jörg, White, Kevin P., Barillas-Mury, Carolina, ...
The complex gene expression responses of Anopheles gambiae to microbial and malaria challenges, injury, and oxidative stress (in the mosquito and/or a cultured cell line) were surveyed by using cDNA...
P25 and P28 proteins of the malaria ookinete surface have multiple and partially redundant functions
Tomas, Ana M., Margos, Gabriele, Dimopoulos, George, Sinha, Ria, ...
The ookinete surface proteins (P25 and P28) are proven antimalarial transmission-blocking vaccine targets, yet their biological functions are unknown. By using single (Sko) and double gene knock-out...
The role of reactive oxygen species on Plasmodium melanotic encapsulation in Anopheles gambiae
Kumar, Sanjeev, Christophides, George K., Cantera, Rafael, Charles, Bradley, Han, Yeon Soo, Meister, Stephan, ...
Malaria transmission depends on the competence of some Anopheles mosquitoes to sustain Plasmodium development (susceptibility). A genetically selected refractory strain of Anopheles gambiae blocks...
Amygdalou, Argyro, Dimopoulos, George, Moukas, Markos, Katsanos, Christos, Katagi, Athina, Mandragos, Costas, ...
Georgopoulos, Dimitris, Matamis, Dimitris, Routsi, Christina, Michalopoulos, Argiris, Maggina, Nina, Dimopoulos, George, ...
Heard, Nicholas A., Holmes, Christopher C., Stephens, David A., Hand, David J., Dimopoulos, George
We present a method for Bayesian model-based hierarchical coclustering of gene expression data and use it to study the temporal transcription responses of an Anopheles gambiae cell line upon...
Anopheles gambiae Immune Responses to Human and Rodent Plasmodium Parasite Species
Dong, Yuemei, Aguilar, Ruth, Xi, Zhiyong, Warr, Emma, Mongin, Emmanuel, Dimopoulos, George
Transmission of malaria is dependent on the successful completion of the Plasmodium lifecycle in the Anopheles vector. Major obstacles are encountered in the midgut tissue, where most parasites are...
Dong, Yuemei, Taylor, Harry E, Dimopoulos, George
Activation of the insect innate immune system is dependent on a limited number of pattern recognition receptors (PRRs) capable of interacting with pathogen-associated molecular pattern. Here we...
Arcà, Bruno, Lombardo, Fabrizio, De Lara Capurro, Margareth, Della Torre, Alessandra, Dimopoulos, George, James, Anthony A., ...
The signal sequence trap method was used to isolate cDNAs corresponding to proteins containing secretory leader peptides and whose genes are expressed specifically in the salivary glands of the...
Dimopoulos, George, Casavant, Thomas L., Chang, Shereen, Scheetz, Todd, Roberts, Chad, Donohue, Micca, ...
Together with AIDS and tuberculosis, malaria is at the top of the list of devastating infectious diseases. However, molecular genetic studies of its major vector, Anopheles gambiae, are still quite...
A cell surface mucin specifically expressed in the midgut of the malaria mosquito Anopheles gambiae
Shen, Zhicheng, Dimopoulos, George, Kafatos, Fotis C., Jacobs-Lorena, Marcelo
An invertebrate intestinal mucin gene, AgMuc1, was isolated from the malaria vector mosquito Anopheles gambiae. The predicted 122-residue protein consists of a central core of seven repeating TTTTVAP...
Molecular immune responses of the mosquito Anopheles gambiae to bacteria and malaria parasites
Dimopoulos, George, Richman, Adam, Müller, Hans-Michael, Kafatos, Fotis C.
Immune responses of the malaria vector mosquito Anopheles gambiae were monitored systematically by the induced expression of five RNA markers after infection challenge. One newly isolated marker...
Dimopoulos, George, Richman, Adam, Della Torre, Alessandra, Kafatos, Fotis C., Louis, Christos
The isolation and study of Anopheles gambiae genes that are differentially expressed in development, notably in tissues associated with the maturation and transmission of the malaria parasite, is...
Gambicin: A novel immune responsive antimicrobial peptide from the malaria vector Anopheles gambiae
Vizioli, Jacopo, Bulet, Philippe, Hoffmann, Jules A., Kafatos, Fotis C., Müller, Hans-Michael, Dimopoulos, George
A novel mosquito antimicrobial peptide, gambicin, and the corresponding gene were isolated in parallel through differential display-PCR, an expressed sequence tag (EST) project, and characterization...
Dimopoulos, George, Christophides, George K., Meister, Stephan, Schultz, Jörg, White, Kevin P., Barillas-Mury, Carolina, ...
The complex gene expression responses of Anopheles gambiae to microbial and malaria challenges, injury, and oxidative stress (in the mosquito and/or a cultured cell line) were surveyed by using cDNA...
P25 and P28 proteins of the malaria ookinete surface have multiple and partially redundant functions
Tomas, Ana M., Margos, Gabriele, Dimopoulos, George, Sinha, Ria, ...
The ookinete surface proteins (P25 and P28) are proven antimalarial transmission-blocking vaccine targets, yet their biological functions are unknown. By using single (Sko) and double gene knock-out...
The role of reactive oxygen species on Plasmodium melanotic encapsulation in Anopheles gambiae
Kumar, Sanjeev, Christophides, George K., Cantera, Rafael, Charles, Bradley, Han, Yeon Soo, Meister, Stephan, ...
Malaria transmission depends on the competence of some Anopheles mosquitoes to sustain Plasmodium development (susceptibility). A genetically selected refractory strain of Anopheles gambiae blocks...
Amygdalou, Argyro, Dimopoulos, George, Moukas, Markos, Katsanos, Christos, Katagi, Athina, Mandragos, Costas, ...
Heard, Nicholas A., Holmes, Christopher C., Stephens, David A., Hand, David J., Dimopoulos, George
We present a method for Bayesian model-based hierarchical coclustering of gene expression data and use it to study the temporal transcription responses of an Anopheles gambiae cell line upon...
Georgopoulos, Dimitris, Matamis, Dimitris, Routsi, Christina, Michalopoulos, Argiris, Maggina, Nina, Dimopoulos, George, ...
Anopheles gambiae Immune Responses to Human and Rodent Plasmodium Parasite Species
Dong, Yuemei, Aguilar, Ruth, Xi, Zhiyong, Warr, Emma, Mongin, Emmanuel, Dimopoulos, George
Transmission of malaria is dependent on the successful completion of the Plasmodium lifecycle in the Anopheles vector. Major obstacles are encountered in the midgut tissue, where most parasites are...
Dong, Yuemei, Taylor, Harry E, Dimopoulos, George
Activation of the insect innate immune system is dependent on a limited number of pattern recognition receptors (PRRs) capable of interacting with pathogen-associated molecular pattern. Here we...
Spatial and sex-specific dissection of the Anopheles gambiae midgut transcriptome
Warr, Emma, Aguilar, Ruth, Dong, Yuemei, Mahairaki, Vassiliki, Dimopoulos, George
Karageorgopoulos, Drosos E., Giannopoulou, Konstantina P., Grammatikos, Alexandros P., Dimopoulos, George, Falagas, Matthew E.
Gomulski, Ludvik M, Dimopoulos, George, Xi, Zhiyong, Soares, Marcelo B, Bonaldo, Maria F, Malacrida, Anna R, ...
Chloroquine Mediated Modulation of Anopheles gambiae Gene Expression
Abrantes, Patrícia, Dimopoulos, George, Grosso, Ana Rita, Do Rosário, Virgílio E., Silveira, Henrique
The Aedes aegypti Toll Pathway Controls Dengue Virus Infection
Xi, Zhiyong, Ramirez, Jose L., Dimopoulos, George
Aedes aegypti, the mosquito vector of dengue viruses, utilizes its innate immune system to ward off a variety of pathogens, some of which can cause disease in humans. To date, the features of...
In this interview, George Dimopoulos focuses on the physiological mechanisms used by mosquitoes to combat Plasmodium falciparum and dengue virus infections. Explanation is given for how key...
Protocol for Mosquito Rearing (A. gambiae)
Das, Suchismita, Garver, Lindsey, Dimopoulos, George
This protocol describes mosquito rearing in the insectary. The insectary rooms are maintained at 28°C and ~80% humidity, with a 12 hr. day/night cycle. For this procedure, you'll need mosquito...
Protocol for Plasmodium falciparum Infections in Mosquitoes and Infection Phenotype Determination
Xi, Zhiyong, Das, Suchismita, Garver, Lindsey, Dimopoulos, George
Once a gene is identified as potentially refractory for malaria, it must be evaluated for its role in preventing Plasmodium infections within the mosquito. This protocol illustrates how the extent of...
Protocol for RNAi Assays in Adult Mosquitoes (A. gambiae)
Garver, Lindsey, Dimopoulos, George
Reverse genetic approaches have proven extremely useful for determining which genes underly resistance to vector pathogens in mosquitoes. This video protocol illustrates a method used by the...
Protocol for Dengue Infections in Mosquitoes (A. aegypti) and Infection Phenotype Determination
Das, Suchismita, Garver, Lindsey, Ramirez, Jose Ruiz, Xi, Zhiyong, Dimopoulos, George
The purpose of this procedure is to infect the Aedes mosquito with dengue virus in a laboratory condition and examine the infection level and dynamic of the virus in the mosquito tissues. This...