Genetic modification of cells by receptor-mediated adenovirus-augmented gene delivery (1994)
Zatloukal, Kurt, Schneeberger, A., Berger, M., Koszik, F., Schmidt, W., Wagner, Ernst, ...
Zatloukal, Kurt, Schmidt, Walter, Cotten, Matt, Wagner, Ernst, Stingl, Georg, Birnstiel, Max L.
The last few years have seen the development of a branch of somatic gene therapy which aims at strengthening the immune surveillance of the body, leading to eradication of disseminated cancer tumor...
Tumoricidal activity of TLR7/8-activated inflammatory dendritic cells
Stary, Georg, Bangert, Christine, Tauber, Martina, Strohal, Robert, Kopp, Tamara, Stingl, Georg
Imiquimod (IMQ), a synthetic agonist to Toll-like receptor (TLR) 7, is being successfully used for the treatment of certain skin neoplasms, but the exact mechanisms by which this compound induces...
Fiebiger, Edda, Meraner, Paul, Weber, Ekkehard, Fang, I-Fei, Stingl, Georg, Ploegh, Hidde, ...
Endo/lysosomal proteases control two key events in antigen (Ag) presentation: the degradation of protein Ag and the generation of peptide-receptive major histocompatibility complex (MHC) class II...
Charbonnier, Anne-Sophie, Kohrgruber, Norbert, Kriehuber, Ernst, Stingl, Georg, Rot, Antal, Maurer, Dieter
Certain types of dendritic cells (DCs) appear in inflammatory lesions of various etiologies, whereas other DCs, e.g., Langerhans cells (LCs), populate peripheral organs constitutively. Until now, the...
Kriehuber, Ernst, Breiteneder-Geleff, Silvana, Groeger, Marion, Soleiman, Afschin, Schoppmann, Sebastian F., Stingl, Georg, ...
A plexus of lymphatic vessels guides interstitial fluid, passenger leukocytes, and tumor cells toward regional lymph nodes. Microvascular endothelial cells (ECs) of lymph channels (LECs) are...
A Skin Homing Molecule Defines the Langerhans Cell Progenitor in Human Peripheral Blood
Strunk, Dirk, Egger, Claudia, Leitner, Gerda, Hanau, Daniel, Stingl, Georg
We have recently described a system for the generation of dendritic cells (DC) and Langerhans cells (LC) from defined CD34+ precursors purified from peripheral blood of healthy adult volunteers (1)....
The PKC inhibitor AEB071 may be a therapeutic option for psoriasis
Skvara, Hans, Dawid, Markus, Kleyn, Elise, Wolff, Barbara, Meingassner, Josef G., Knight, Hilary, ...
PKC isoforms t, α, and β play fundamental roles in the activation of T cells and other immune cell functions. Here we show that the PKC inhibitor AEB071 both abolishes the production of several...