New tricks for old NODs (2008)
Pietras, Eric M, Cheng, Genhong
Abstract Recent work has identified the human NOD-like receptor NLRX1 as a negative regulator of intracellular signaling leading to type I interferon production. Here we discuss these findings and...
MicroRNA-155 is induced during the macrophage inflammatory response (2007)
O'Connell, Ryan M., Taganov, Konstantin D., Boldin, Mark P., Cheng, Genhong, Baltimore, David
The mammalian inflammatory response to infection involves the induction of several hundred genes, a process that must be carefully regulated to achieve pathogen clearance and prevent the consequences...
Zarnegar, Brian, He, Jeannie Q., Oganesyan, Gagik, Hoffmann, Alexander, Baltimore, David, Cheng, Genhong
B lymphocytes can be activated by many different stimuli. However, the mechanisms responsible for the signaling and functional specificities of individual stimuli remain to be elucidated. Here, we...
Most human breast cancer cells are derived from epithelial cells. Previously studies indicated that about 20% of breast cancer patients carrying tumor cells with overexpression of Her-2/Neu....
Cooperation of multiple signaling pathways in CD40-regulated gene expression in B lymphocytes (2002)
Dadgostar, Hajir, Zarnegar, Brian, Hoffmann, Alexander, Qin, Xiao-Feng, Truong, Uyen, Rao, Govinda, ...
CD40/CD40L interaction is essential for multiple biological events in T dependent humoral immune responses, including B cell survival and proliferation, germinal center and memory B cell formation,...
Requirements for activation and RAFT localization of the T-lymphocyte kinase Rlk/Txk (2001)
Chamorro, Mario, Czar, Michael J, Debnath, Jayanta, Cheng, Genhong, Lenardo, Michael J, Varmus, Harold E, ...
Abstract Background The Tec family kinases are implicated in signaling from lymphocyte antigen receptors and are activated following phosphorylation by Src kinases. For most Tec kinases, this...
Lee, Ho H., Dempsey, Paul W., Parks, Thomas P., Zhu, Xiaoqing, Baltimore, David, Cheng, Genhong
Several tumor necrosis factor receptor-associated factor (TRAF) family proteins including TRAF2, TRAF3, TRAF5, and TRAF6, as well as Jak3, have been implicated as potential mediators of CD40...
Proline-Rich Sequences that Bind to Src Homology 3 Domains with Individual Specificities (1995)
Alexandropoulos, Konstantina, Cheng, Genhong, Baltimore, David
To study the binding specificity of Src homology 3 (SH3) domains, we have screened a mouse embryonic expression library for peptide fragments that interact with them. Several clones were identified...
Cheng, Genhong, Ze, Zheng-Sheng, Baltimore, David
Bruton's tyrosine kinase (Btk) is a recently described B-cell-specific tyrosine kinase. Mutations in this gene lead to human X chromosome-linked agammaglobulinemia and murine X-linked...
Thesis (Ph. D.)--Sue Golding Graduate Division of Medical Sciences, Albert Einstein College of Medicine, Yeshiva University, 1990.
Lee, Ho H., Dempsey, Paul W., Parks, Thomas P., Zhu, Xiaoqing, Baltimore, David, Cheng, Genhong
Several tumor necrosis factor receptor-associated factor (TRAF) family proteins including TRAF2, TRAF3, TRAF5, and TRAF6, as well as Jak3, have been implicated as potential mediators of CD40...
Lee, Ho H., Dadgostar, Hajir, Cheng, Qingwen, Shu, Junyan, Cheng, Genhong
Activation of CD40 is essential for thymus-dependent humoral immune responses and rescuing B cells from apoptosis. Many of the effects of CD40 are believed to be achieved through altered gene...
Requirements for activation and RAFT localization of the T-lymphocyte kinase Rlk/Txk
Chamorro, Mario, Czar, Michael J, Debnath, Jayanta, Cheng, Genhong, Lenardo, Michael J, Varmus, Harold E, ...
Chin, Arnold I-Dah, Shu, Junyan, Shan Shi, Chong, Yao, Zhengbin, Kehrl, John H., Cheng, Genhong
Tumor necrosis factor (TNF) receptor-associated factors (TRAFs) are mediators of many members of the TNF receptor superfamily and can activate both the nuclear factor κB (NF-κB) and...
Jewett, Anahid, Hume, Wyatt R., Le, Ho, Huynh, Tri N., Han, Yiping W., Cheng, Genhong, ...
It is largely unknown why a variety of bacteria present in the oral cavity are capable of establishing themselves in the periodontal pockets of nonimmunocompromised individuals in the presence of...
MEKK1 Is Essential for DT40 Cell Apoptosis in Response to Microtubule Disruption
Kwan, Raymond, Burnside, Joan, Kurosaki, Tomohiro, Cheng, Genhong
Vinblastine and other microtubule-damaging agents, such as nocodazole and paclitaxel, cause cell cycle arrest at the G2/M transition and promote apoptosis in eukaryotic cells. The roles of these...
Cooperation of multiple signaling pathways in CD40-regulated gene expression in B lymphocytes
Dadgostar, Hajir, Zarnegar, Brian, Hoffmann, Alexander, Qin, Xiao-Feng, Truong, Uyen, Rao, Govinda, ...
CD40/CD40L interaction is essential for multiple biological events in T dependent humoral immune responses, including B cell survival and proliferation, germinal center and memory B cell formation,...
Ronni, Tapani, Agarwal, Vishal, Haykinson, Michael, Haberland, Margaret E., Cheng, Genhong, Smale, Stephen T.
Toll-like receptor 4 (TLR4) mediates the host response to lipopolysaccharide (LPS) by promoting the activation of pro- and anti-inflammatory cytokine genes. To activate each gene, numerous signal...
NF-κB Inhibits Gammaherpesvirus Lytic Replication
Brown, Helen J., Song, Moon Jung, Deng, Hongyu, Wu, Ting-Ting, Cheng, Genhong, Sun, Ren
Nasopharyngeal carcinoma, Kaposi's sarcoma, and B-cell lymphomas are human malignancies associated with gammaherpesvirus infections. Members of this virus family are characterized by their ability to...
Zarnegar, Brian, He, Jeannie Q., Oganesyan, Gagik, Hoffmann, Alexander, Baltimore, David, Cheng, Genhong
B lymphocytes can be activated by many different stimuli. However, the mechanisms responsible for the signaling and functional specificities of individual stimuli remain to be elucidated. Here, we...
Negative Regulation of NF-κB Signaling by PIAS1†
Liu, Bin, Yang, Randy, Wong, Kelly A., Getman, Crescent, Stein, Natalie, Teitell, Michael A., ...
The NF-κB family of transcription factors is activated by a wide variety of signals to regulate a spectrum of cellular processes. The proper regulation of NF-κB activity is critical, since abnormal...
Sepsis-induced suppression of lung innate immunity is mediated by IRAK-M
Deng, Jane C., Cheng, Genhong, Newstead, Michael W., Zeng, Xianying, Kobayashi, Koichi, Flavell, Richard A., ...
Sepsis results in a state of relative immunosuppression, rendering critically ill patients susceptible to secondary infections and increased mortality. Monocytes isolated from septic patients and...
TLR agonists regulate PDGF-B production and cell proliferation through TGF-β/type I IFN crosstalk
Chow, Edward K, O'Connell, Ryan M, Schilling, Stephen, Wang, Xiao-Fan, Fu, Xin-Yuan, Cheng, Genhong
Transforming growth factor-β (TGF-β) and type I interferon (IFN) autocrine/paracrine loops are recognized as key mediators of signaling cascades that control a variety of cellular functions. Here,...
Lee, Ho H., Dempsey, Paul W., Parks, Thomas P., Zhu, Xiaoqing, Baltimore, David, Cheng, Genhong
Several tumor necrosis factor receptor-associated factor (TRAF) family proteins including TRAF2, TRAF3, TRAF5, and TRAF6, as well as Jak3, have been implicated as potential mediators of CD40...
Lee, Ho H., Dadgostar, Hajir, Cheng, Qingwen, Shu, Junyan, Cheng, Genhong
Activation of CD40 is essential for thymus-dependent humoral immune responses and rescuing B cells from apoptosis. Many of the effects of CD40 are believed to be achieved through altered gene...
Requirements for activation and RAFT localization of the T-lymphocyte kinase Rlk/Txk
Chamorro, Mario, Czar, Michael J, Debnath, Jayanta, Cheng, Genhong, Lenardo, Michael J, Varmus, Harold E, ...
Chin, Arnold I-Dah, Shu, Junyan, Shan Shi, Chong, Yao, Zhengbin, Kehrl, John H., Cheng, Genhong
Tumor necrosis factor (TNF) receptor-associated factors (TRAFs) are mediators of many members of the TNF receptor superfamily and can activate both the nuclear factor κB (NF-κB) and...
Jewett, Anahid, Hume, Wyatt R., Le, Ho, Huynh, Tri N., Han, Yiping W., Cheng, Genhong, ...
It is largely unknown why a variety of bacteria present in the oral cavity are capable of establishing themselves in the periodontal pockets of nonimmunocompromised individuals in the presence of...
MEKK1 Is Essential for DT40 Cell Apoptosis in Response to Microtubule Disruption
Kwan, Raymond, Burnside, Joan, Kurosaki, Tomohiro, Cheng, Genhong
Vinblastine and other microtubule-damaging agents, such as nocodazole and paclitaxel, cause cell cycle arrest at the G2/M transition and promote apoptosis in eukaryotic cells. The roles of these...
Cooperation of multiple signaling pathways in CD40-regulated gene expression in B lymphocytes
Dadgostar, Hajir, Zarnegar, Brian, Hoffmann, Alexander, Qin, Xiao-Feng, Truong, Uyen, Rao, Govinda, ...
CD40/CD40L interaction is essential for multiple biological events in T dependent humoral immune responses, including B cell survival and proliferation, germinal center and memory B cell formation,...
Ronni, Tapani, Agarwal, Vishal, Haykinson, Michael, Haberland, Margaret E., Cheng, Genhong, Smale, Stephen T.
Toll-like receptor 4 (TLR4) mediates the host response to lipopolysaccharide (LPS) by promoting the activation of pro- and anti-inflammatory cytokine genes. To activate each gene, numerous signal...
NF-κB Inhibits Gammaherpesvirus Lytic Replication
Brown, Helen J., Song, Moon Jung, Deng, Hongyu, Wu, Ting-Ting, Cheng, Genhong, Sun, Ren
Nasopharyngeal carcinoma, Kaposi's sarcoma, and B-cell lymphomas are human malignancies associated with gammaherpesvirus infections. Members of this virus family are characterized by their ability to...
Zarnegar, Brian, He, Jeannie Q., Oganesyan, Gagik, Hoffmann, Alexander, Baltimore, David, Cheng, Genhong
B lymphocytes can be activated by many different stimuli. However, the mechanisms responsible for the signaling and functional specificities of individual stimuli remain to be elucidated. Here, we...
Negative Regulation of NF-κB Signaling by PIAS1†
Liu, Bin, Yang, Randy, Wong, Kelly A., Getman, Crescent, Stein, Natalie, Teitell, Michael A., ...
The NF-κB family of transcription factors is activated by a wide variety of signals to regulate a spectrum of cellular processes. The proper regulation of NF-κB activity is critical, since abnormal...
TLR agonists regulate PDGF-B production and cell proliferation through TGF-β/type I IFN crosstalk
Chow, Edward K, O'Connell, Ryan M, Schilling, Stephen, Wang, Xiao-Fan, Fu, Xin-Yuan, Cheng, Genhong
Transforming growth factor-β (TGF-β) and type I interferon (IFN) autocrine/paracrine loops are recognized as key mediators of signaling cascades that control a variety of cellular functions. Here,...
Sepsis-induced suppression of lung innate immunity is mediated by IRAK-M
Deng, Jane C., Cheng, Genhong, Newstead, Michael W., Zeng, Xianying, Kobayashi, Koichi, Flavell, Richard A., ...
Sepsis results in a state of relative immunosuppression, rendering critically ill patients susceptible to secondary infections and increased mortality. Monocytes isolated from septic patients and...
Regulation of antiviral responses by a direct and specific interaction between TRAF3 and Cardif
Saha, Supriya K, Pietras, Eric M, He, Jeannie Q, Kang, Jason R, Liu, Su-Yang, Oganesyan, Gagik, ...
Upon recognition of viral infection, RIG-I and Helicard recruit a newly identified adapter termed Cardif, which induces type I interferon (IFN)-mediated antiviral responses through an unknown...
MicroRNA-155 is induced during the macrophage inflammatory response
O'Connell, Ryan M., Taganov, Konstantin D., Boldin, Mark P., Cheng, Genhong, Baltimore, David
The mammalian inflammatory response to infection involves the induction of several hundred genes, a process that must be carefully regulated to achieve pathogen clearance and prevent the consequences...
Rescue of TRAF3-null mice by p100 NF-κB deficiency
He, Jeannie Q., Zarnegar, Brian, Oganesyan, Gagik, Saha, Supriya K., Yamazaki, Soh, Doyle, Sean E., ...
Proper activation of nuclear factor (NF)–κB transcription factors is critical in regulating fundamental biological processes such as cell survival and proliferation, as well as in inflammatory and...
A role for IRF3-dependent RXRα repression in hepatotoxicity associated with viral infections
Chow, Edward K., Castrillo, Antonio, Shahangian, Arash, Pei, Liming, O'Connell, Ryan M., Modlin, Robert L., ...
Viral infections and antiviral responses have been linked to several metabolic diseases, including Reye's syndrome, which is aspirin-induced hepatotoxicity in the context of a viral infection. We...
Toll-like Receptors Induce a Phagocytic Gene Program through p38
Doyle, Sean E., O'Connell, Ryan M., Miranda, Gustavo A., Vaidya, Sagar A., Chow, Edward K., Liu, Philip T., ...
Toll-like receptor (TLR) signaling and phagocytosis are hallmarks of macrophage-mediated innate immune responses to bacterial infection. However, the relationship between these two processes is not...
Type I Interferon Production Enhances Susceptibility to Listeria monocytogenes Infection
O'Connell, Ryan M., Saha, Supriya K., Vaidya, Sagar A., Bruhn, Kevin W., Miranda, Gustavo A., Zarnegar, Brian, ...
Numerous bacterial products such as lipopolysaccharide potently induce type I interferons (IFNs); however, the contribution of this innate response to host defense against bacterial infection remains...
Perry, Andrea K., Chow, Edward K., Goodnough, Julia B., Yeh, Wen-Chen, Cheng, Genhong
TANK-binding kinase-1 (TBK1) and the inducible IκB kinase (IKK-i) have been shown recently to activate interferon (IFN) regulatory factor-3 (IRF3), the primary transcription factor regulating...
The type I IFN induction pathway constrains Th17-mediated autoimmune inflammation in mice
Guo, Beichu, Chang, Elmer Y., Cheng, Genhong
IFN-β, a type I IFN, is widely used for the treatment of MS. However, the mechanisms behind its therapeutic efficacy are not well understood. Using a murine model of MS, EAE, we demonstrate that the...
A Repetitive Region of Gammaherpesvirus Genomic DNA Is a Ligand for Induction of Type I Interferon▿
Sanchez, David Jesse, Miranda, Daniel, Arumugaswami, Vaithilingaraja, Hwang, Seungmin, Singer, Adam E., Senaati, Ashkon, ...
Innate immune responses against viral infection, especially the induction of type I interferon, are critical for limiting the replication of the virus. Although it has been shown that DNA can induce...
Control of canonical NF-κB activation through the NIK–IKK complex pathway
Zarnegar, Brian, Yamazaki, Soh, He, Jeannie Q., Cheng, Genhong
Articles in recent years have described two separate and distinct NF-κB activation pathways that result in the differential activation of p50- or p52-containing NF-κB complexes. Studies examining...
Wong, Pak Kin, Yu, Fuqu, Shahangian, Arash, Cheng, Genhong, Sun, Ren, Ho, Chih-Ming
A mixture of drugs is often more effective than using a single effector. However, it is extremely challenging to identify potent drug combinations by trial and error because of the large number of...