Ruvkun, Gary, Zuber, Maria T., Gilbert, Walter, Church, George M., Finney, Michael, Johnson, Sarah Stewart, ...
Lifespan Regulation by Evolutionarily Conserved Genes Essential for Viability (2007)
Evolutionarily conserved mechanisms that control aging are predicted to have prereproductive functions in order to be subject to natural selection. Genes that are essential for growth and development...
Lifespan regulation by evolutionarily conserved genes essential for viability (2007)
Sean Patrick Curran, Gary Ruvkun
Evolutionarily conserved mechanisms that control aging are predicted to have pre-reproductive functions in order to be subject to natural selection. Genes that are essential for growth and...
Patrick J. Hu, Jinling Xu, Gary Ruvkun
Akt/protein kinase B (PKB) functions in conserved signaling cascades that regulate growth and metabolism. In humans, Akt/PKB is dysregulated in diabetes and cancer; in Caenorhabditis elegans, Akt/PKB...
Duchaine, Thomas F., Wohlschlegel, James A., Kennedy, Scott, Bei, Yanxia, Conte, Darryl, Pang, Ka Ming, ...
In plants, animals, and fungi, members of the Dicer family of RNase III-related enzymes process double-stranded RNA (dsRNA) to initiate small-RNA-mediated gene-silencing mechanisms. To learn how C....
Functional Genomic Analysis of C. elegans Molting (2005)
Alison R. Frand, Sascha Russel, Gary Ruvkun
The authors use a genome-wide RNA-interference screen to identify and characterize genes involved in C. elegans molting. They investigate regulatory networks involved in molting, lending important...
Functional Genomic Analysis of C. elegans Molting (2005)
Alison R. Frand, Sascha Russel, Gary Ruvkun
Although the molting cycle is a hallmark of insects and nematodes, neither the endocrine control of molting via size, stage, and nutritional inputs nor the enzymatic mechanism for synthesis and...
Grishok, Alla, Pasquinelli, Amy E., Conte, Darryl, Li, Na, Parrish, Susan, Ha, Ilho, ...
RNAi is a gene-silencing phenomenon triggered by double-stranded (ds) RNA and involves the generation of 21 to 26 nt RNA segments that guide mRNA destruction. In Caenorhabditis elegans, lin-4 and...
Tissenbaum, Heidi A., Hawdon, John, Perregaux, Melissa, Hotez, Peter, Guarente, Leonard, Ruvkun, Gary
Converging TGF-β and insulin-like neuroendocrine signaling pathways regulate whether Caenorhabditis elegans develops reproductively or arrests at the dauer larval stage. We examined whether...
Nasrin, Nargis, Ogg, Scott, Cahill, Catherine M., Biggs, William, Nui, Simin, Dore, Justin, ...
Insulin negatively regulates expression of the insulin-like growth factor binding protein 1 (IGFBP-1) gene by means of an insulin-responsive element (IRE) that also contributes to glucocorticoid...
The activity of transcription factors modulates several neural pathways that mediate complex behaviors. We describe here the role of the POU transcription factor UNC-86 in the olfactory behavior of...
Li, Weiqing, Kennedy, Scott G., Ruvkun, Gary
In Caenorhabditis elegans, the decision to enter a developmentally arrested dauer larval stage is triggered by a combination of signals from sensory neurons in response to environmental cues, which...
Identification of many microRNAs that copurify with polyribosomes in mammalian neurons
Kim, John, Krichevsky, Anna, Grad, Yonatan, Hayes, Gabriel D., Kosik, Kenneth S., Church, George M., ...
Localized translation in mammalian dendrites may play a role in synaptic plasticity and contribute to the molecular basis for learning and memory. The regulatory mechanisms that control localized...
Patterson, Garth I., Koweek, Allison, Wong, Arthur, Liu, Yanxia, Ruvkun, Gary
Signals from TGF-β superfamily receptors are transduced to the nucleus by Smad proteins, which transcriptionally activate target genes. In Caenorhabditis elegans, defects in a TGF-β-related pathway...
Paradis, Suzanne, Ailion, Michael, Toker, Alex, Thomas, James H., Ruvkun, Gary
An insulin receptor-like signaling pathway regulates Caenorhabditis elegans metabolism, development, and longevity. Inactivation of the insulin receptor homolog DAF-2, the AGE-1 PI3K, or the AKT-1...
Alternative olfactory neuron fates are specified by the LIM homeobox gene lim-4
Sagasti, Alvaro, Hobert, Oliver, Troemel, Emily R., Ruvkun, Gary, Bargmann, Cornelia I.
The Caenorhabditis elegans AWA, AWB, and AWC olfactory neurons are each required for the recognition of a specific subset of volatile odorants. lim-4 mutants express an AWC reporter gene...
Paradis, Suzanne, Ruvkun, Gary
A neurosecretory pathway regulates a reversible developmental arrest and metabolic shift at the Caenorhabditis elegans dauer larval stage. Defects in an insulin-like signaling pathway cause arrest at...
A systematic RNAi screen for longevity genes in C. elegans
Hamilton, Benjamin, Dong, Yuqing, Shindo, Mami, Liu, Wenyu, Odell, Ian, Ruvkun, Gary, ...
We report here the first genome-wide functional genomic screen for longevity genes. We systematically surveyed Caenorhabditis elegans genes using large-scale RNA interference (RNAi), and found that...
Functional Genomic Analysis of C. elegans Molting
Frand, Alison R, Russel, Sascha, Ruvkun, Gary
Although the molting cycle is a hallmark of insects and nematodes, neither the endocrine control of molting via size, stage, and nutritional inputs nor the enzymatic mechanism for synthesis and...
A uniform system for microRNA annotation
AMBROS, VICTOR, BARTEL, BONNIE, BARTEL, DAVID P., BURGE, CHRISTOPHER B., CARRINGTON, JAMES C., CHEN, XUEMEI, ...
MicroRNAs (miRNAs) are small noncoding RNA gene products about 22 nt long that are processed by Dicer from precursors with a characteristic hairpin secondary structure. Guidelines are presented for...
Pierce, Sarah B., Costa, Michael, Wisotzkey, Robert, Devadhar, Sharmila, Homburger, Sheila A., Buchman, Andrew R., ...
The activity of the DAF-2 insulin-like receptor is required for Caenorhabditis elegans reproductive growth and normal adult life span. Informatic analysis identified 37 C. elegans genes predicted to...
Two Membrane-Associated Tyrosine Phosphatase Homologs Potentiate C. elegans AKT-1/PKB Signaling
Hu, Patrick J, Xu, Jinling, Ruvkun, Gary
Akt/protein kinase B (PKB) functions in conserved signaling cascades that regulate growth and metabolism. In humans, Akt/PKB is dysregulated in diabetes and cancer; in Caenorhabditis elegans, Akt/PKB...
Tissenbaum, Heidi A., Hawdon, John, Perregaux, Melissa, Hotez, Peter, Guarente, Leonard, Ruvkun, Gary
Converging TGF-β and insulin-like neuroendocrine signaling pathways regulate whether Caenorhabditis elegans develops reproductively or arrests at the dauer larval stage. We examined whether...
Nasrin, Nargis, Ogg, Scott, Cahill, Catherine M., Biggs, William, Nui, Simin, Dore, Justin, ...
Insulin negatively regulates expression of the insulin-like growth factor binding protein 1 (IGFBP-1) gene by means of an insulin-responsive element (IRE) that also contributes to glucocorticoid...
The activity of transcription factors modulates several neural pathways that mediate complex behaviors. We describe here the role of the POU transcription factor UNC-86 in the olfactory behavior of...
Li, Weiqing, Kennedy, Scott G., Ruvkun, Gary
In Caenorhabditis elegans, the decision to enter a developmentally arrested dauer larval stage is triggered by a combination of signals from sensory neurons in response to environmental cues, which...
Pierce, Sarah B., Costa, Michael, Wisotzkey, Robert, Devadhar, Sharmila, Homburger, Sheila A., Buchman, Andrew R., ...
The activity of the DAF-2 insulin-like receptor is required for Caenorhabditis elegans reproductive growth and normal adult life span. Informatic analysis identified 37 C. elegans genes predicted to...
Identification of many microRNAs that copurify with polyribosomes in mammalian neurons
Kim, John, Krichevsky, Anna, Grad, Yonatan, Hayes, Gabriel D., Kosik, Kenneth S., Church, George M., ...
Localized translation in mammalian dendrites may play a role in synaptic plasticity and contribute to the molecular basis for learning and memory. The regulatory mechanisms that control localized...
Patterson, Garth I., Koweek, Allison, Wong, Arthur, Liu, Yanxia, Ruvkun, Gary
Signals from TGF-β superfamily receptors are transduced to the nucleus by Smad proteins, which transcriptionally activate target genes. In Caenorhabditis elegans, defects in a TGF-β-related pathway...
Paradis, Suzanne, Ailion, Michael, Toker, Alex, Thomas, James H., Ruvkun, Gary
An insulin receptor-like signaling pathway regulates Caenorhabditis elegans metabolism, development, and longevity. Inactivation of the insulin receptor homolog DAF-2, the AGE-1 PI3K, or the AKT-1...
Alternative olfactory neuron fates are specified by the LIM homeobox gene lim-4
Sagasti, Alvaro, Hobert, Oliver, Troemel, Emily R., Ruvkun, Gary, Bargmann, Cornelia I.
The Caenorhabditis elegans AWA, AWB, and AWC olfactory neurons are each required for the recognition of a specific subset of volatile odorants. lim-4 mutants express an AWC reporter gene...
Paradis, Suzanne, Ruvkun, Gary
A neurosecretory pathway regulates a reversible developmental arrest and metabolic shift at the Caenorhabditis elegans dauer larval stage. Defects in an insulin-like signaling pathway cause arrest at...
A systematic RNAi screen for longevity genes in C. elegans
Hamilton, Benjamin, Dong, Yuqing, Shindo, Mami, Liu, Wenyu, Odell, Ian, Ruvkun, Gary, ...
We report here the first genome-wide functional genomic screen for longevity genes. We systematically surveyed Caenorhabditis elegans genes using large-scale RNA interference (RNAi), and found that...
Functional Genomic Analysis of C. elegans Molting
Frand, Alison R, Russel, Sascha, Ruvkun, Gary
Although the molting cycle is a hallmark of insects and nematodes, neither the endocrine control of molting via size, stage, and nutritional inputs nor the enzymatic mechanism for synthesis and...
A uniform system for microRNA annotation
AMBROS, VICTOR, BARTEL, BONNIE, BARTEL, DAVID P., BURGE, CHRISTOPHER B., CARRINGTON, JAMES C., CHEN, XUEMEI, ...
MicroRNAs (miRNAs) are small noncoding RNA gene products about 22 nt long that are processed by Dicer from precursors with a characteristic hairpin secondary structure. Guidelines are presented for...
Two Membrane-Associated Tyrosine Phosphatase Homologs Potentiate C. elegans AKT-1/PKB Signaling
Hu, Patrick J, Xu, Jinling, Ruvkun, Gary
Akt/protein kinase B (PKB) functions in conserved signaling cascades that regulate growth and metabolism. In humans, Akt/PKB is dysregulated in diabetes and cancer; in Caenorhabditis elegans, Akt/PKB...
Lifespan Regulation by Evolutionarily Conserved Genes Essential for Viability
Evolutionarily conserved mechanisms that control aging are predicted to have prereproductive functions in order to be subject to natural selection. Genes that are essential for growth and development...
Kim, Nahui, Dempsey, Catherine M., Kuan, Chih-Jen, Zoval, Jim V., O'Rourke, Eyleen, Ruvkun, Gary, ...
The gravity response is an array of behavioral and physiological plasticity elicited by changes in ambient mechanical force and is an evolutionarily ancient adaptive mechanism. We show in...
Hobert, Oliver, Moerman, Donald G., Clark, Kathleen A., Beckerle, Mary C., Ruvkun, Gary
We describe here the molecular and functional characterization of the Caenorhabditis elegans unc-97 gene, whose gene product constitutes a novel component of muscular adherens junctions. UNC-97 and...
Gene activities that mediate increased life span of C. elegans insulin-like signaling mutants
Samuelson, Andrew V., Carr, Christopher E., Ruvkun, Gary
Genetic and RNA interference (RNAi) screens for life span regulatory genes have revealed that the daf-2 insulin-like signaling pathway plays a major role in Caenorhabditis elegans longevity. This...
Miniprimer PCR, a New Lens for Viewing the Microbial World▿ †
Isenbarger, Thomas A., Finney, Michael, Ríos-Velázquez, Carlos, Handelsman, Jo, Ruvkun, Gary
Molecular methods based on the 16S rRNA gene sequence are used widely in microbial ecology to reveal the diversity of microbial populations in environmental samples. Here we show that a new PCR...