Han, Gangwen, Lu, Shi-Long, Li, Allen G., He, Wei, Corless, Christopher L., Kulesz-Martin, Molly, ...
In the present study, we demonstrated that human skin cancers frequently overexpress TGF-β1 but exhibit decreased expression of the TGF-β type II receptor (TGF-βRII). To understand how this...
Han, Gangwen, Lu, Shi-Long, Li, Allen G., He, Wei, Corless, Christopher L., Kulesz-Martin, Molly, ...
In the present study, we demonstrated that human skin cancers frequently overexpress TGF-β1 but exhibit decreased expression of the TGF-β type II receptor (TGF-βRII). To understand how this...
Targeted Disruption of TGF-β/Smad3 Signaling Modulates Skin Fibrosis in a Mouse Model of Scleroderma
Lakos, Gabriella, Takagawa, Shinsuke, Chen, Shu-Jen, Ferreira, Ahalia M., Han, Gangwen, Masuda, Koichi, ...
Transforming growth factor-β (TGF-β) is a potent stimulus of connective tissue accumulation, and is implicated in the pathogenesis of scleroderma and other fibrotic disorders. Smad3 functions as a...
Hoot, Kristina E., Lighthall, Jessyka, Han, Gangwen, Lu, Shi-Long, Li, Allen, Ju, Wenjun, ...
TGF-β and its signaling mediators, Smad2, -3, and -4, are involved with tumor suppression and promotion functions. Smad4–/– mouse epidermis develops spontaneous skin squamous cell carcinomas...
Descargues, Pascal, Sil, Alok K., Sano, Yuji, Korchynskyi, Olexandr, Han, Gangwen, Owens, Philip, ...
Cell-cycle exit and differentiation of suprabasal epidermal keratinocytes require nuclear IκB kinase α (IKKα), but not its protein kinase activity. IKKα also is a suppressor of squamous cell...