Welsch, Christoph, Domingues, Francisco S, Susser, Simone, Antes, Iris, Hartmann, Christoph, Mayr, Gabriele, ...
Abstract Background The inhibitor telaprevir (VX-950) of the hepatitis C virus (HCV) protease NS3-4A has been tested in a recent phase 1b clinical trial in patients infected with HCV genotype 1. This...
Variants in a Novel Epidermal Collagen Gene (COL29A1) Are Associated with Atopic Dermatitis (2007)
Cilla Söderhäll, Ingo Marenholz, Tamara Kerscher, Franz Rüschendorf, Jorge Esparza-Gordillo, Margitta Worm, ...
Atopic dermatitis (AD) is a common chronic inflammatory skin disorder and a major manifestation of allergic disease. AD typically presents in early childhood often preceding the onset of an allergic...
Comparative Analysis of Protein Structure Alignments (2007)
Mayr, Gabriele, Domingues, Francisco S, Lackner, Peter
Abstract Background Several methods are currently available for the comparison of protein structures. These methods have been analysed regarding the performance in the identification of...
A Novel Intron Element Operates Posttranscriptionally To Regulate Human N-myc Expression
Sivak, Louise E., Pont-Kingdon, Geneviève, Le, Kim, Mayr, Gabriele, Tai, Kuei-Fang, Stevens, Ben T., ...
Precisely regulated expression of oncogenes and tumor suppressor genes is essential for normal development, and deregulated expression can lead to cancer. The human N-myc gene normally is expressed...
A Novel Intron Element Operates Posttranscriptionally To Regulate Human N-myc Expression
Sivak, Louise E., Pont-Kingdon, Geneviève, Le, Kim, Mayr, Gabriele, Tai, Kuei-Fang, Stevens, Ben T., ...
Precisely regulated expression of oncogenes and tumor suppressor genes is essential for normal development, and deregulated expression can lead to cancer. The human N-myc gene normally is expressed...
Systematic Association Mapping Identifies NELL1 as a Novel IBD Disease Gene
Franke, Andre, Hampe, Jochen, Rosenstiel, Philip, Becker, Christian, Wagner, Florian, Häsler, Robert, ...
Crohn disease (CD), a sub-entity of inflammatory bowel disease (IBD), is a complex polygenic disorder. Although recent studies have successfully identified CD-associated genetic variants, these...
Variants in a Novel Epidermal Collagen Gene (COL29A1) Are Associated with Atopic Dermatitis
Söderhäll, Cilla, Marenholz, Ingo, Kerscher, Tamara, Rüschendorf, Franz, Esparza-Gordillo, Jorge, Worm, Margitta, ...
Atopic dermatitis (AD) is a common chronic inflammatory skin disorder and a major manifestation of allergic disease. AD typically presents in early childhood often preceding the onset of an allergic...
Welsch, Christoph, Domingues, Francisco S, Susser, Simone, Antes, Iris, Hartmann, Christoph, Mayr, Gabriele, ...
Structural analysis of the inhibitor Telaprevir (VX-950) of the hepatitis C virus (HCV) protease NS3-4A shows that mutations at V36 and/or T54 result in impaired interaction with VX-950, explaining...