Pierron, Gérard, Pallotta, Dominick, Bénard, Marianne
The 1-kb DNA fragment upstream of the ardC actin gene of Physarum polycephalum promotes the transcription of a reporter gene either in a transient-plasmid assay or as an integrated copy in an ectopic...
Replicational organization of three weakly expressed loci in Physarum polycephalum
Maric, Chrystelle, Swanston, Emma, Bailey, Juliet, Pierron, Gérard
We previously mapped early-activated replication origins in the promoter regions of five abundantly transcribed genes in the slime mold Physarum polycephalum. This physical linkage between origins...
Inhibition of Macroautophagy Triggers Apoptosis†
Boya, Patricia, González-Polo, Rosa-Ana, Casares, Noelia, Perfettini, Jean-Luc, Dessen, Philippe, Larochette, Nathanael, ...
Mammalian cells were observed to die under conditions in which nutrients were depleted and, simultaneously, macroautophagy was inhibited either genetically (by a small interfering RNA targeting Atg5,...
Developmentally regulated usage of Physarum DNA replication origins
Maric, Chrystelle, Bénard, Marianne, Pierron, Gérard
To determine the extent to which eukaryotic replication origins are developmentally regulated in transcriptionally competent cells, we compared origin use in untreated growing amoebae and plasmodia...
Pierron, Gérard, Pallotta, Dominick, Bénard, Marianne
The 1-kb DNA fragment upstream of the ardC actin gene of Physarum polycephalum promotes the transcription of a reporter gene either in a transient-plasmid assay or as an integrated copy in an ectopic...
Replicational organization of three weakly expressed loci in Physarum polycephalum
Maric, Chrystelle, Swanston, Emma, Bailey, Juliet, Pierron, Gérard
We previously mapped early-activated replication origins in the promoter regions of five abundantly transcribed genes in the slime mold Physarum polycephalum. This physical linkage between origins...
Inhibition of Macroautophagy Triggers Apoptosis†
Boya, Patricia, González-Polo, Rosa-Ana, Casares, Noelia, Perfettini, Jean-Luc, Dessen, Philippe, Larochette, Nathanael, ...
Mammalian cells were observed to die under conditions in which nutrients were depleted and, simultaneously, macroautophagy was inhibited either genetically (by a small interfering RNA targeting Atg5,...
Developmentally regulated usage of Physarum DNA replication origins
Maric, Chrystelle, Bénard, Marianne, Pierron, Gérard
To determine the extent to which eukaryotic replication origins are developmentally regulated in transcriptionally competent cells, we compared origin use in untreated growing amoebae and plasmodia...
Dewannieux, Marie, Harper, Francis, Richaud, Aurélien, Letzelter, Claire, Ribet, David, Pierron, Gérard, ...
Human Endogenous Retroviruses are expected to be the remnants of ancestral infections of primates by active retroviruses that have thereafter been transmitted in a Mendelian fashion. Here, we derived...
Murine MusD Retrotransposon: Structure and Molecular Evolution of an “Intracellularized” Retrovirus▿
Ribet, David, Harper, Francis, Dewannieux, Marie, Pierron, Gérard, Heidmann, Thierry
We had previously identified active autonomous copies of the MusD long terminal repeat-retrotransposon family, which have retained transpositional activity. These elements are closely related to...
Bénard, Marianne, Maric, Chrystelle, Pierron, Gérard
Invariance of temporal order of genome replication in eukaryotic cells and its correlation with gene activity has been well-documented. However, recent data suggest a relax control of replication...
Caspase-dependent immunogenicity of doxorubicin-induced tumor cell death
Casares, Noelia, Pequignot, Marie O., Tesniere, Antoine, Ghiringhelli, François, Roux, Stéphan, Chaput, Nathalie, ...
Systemic anticancer chemotherapy is immunosuppressive and mostly induces nonimmunogenic tumor cell death. Here, we show that even in the absence of any adjuvant, tumor cells dying in response to...
Functional and physical interaction between Bcl-XL and a BH3-like domain in Beclin-1
Maiuri, M Chiara, Le Toumelin, Gaëtane, Criollo, Alfredo, Rain, Jean-Christophe, Gautier, Fabien, Juin, Philippe, ...
The anti-apoptotic proteins Bcl-2 and Bcl-XL bind and inhibit Beclin-1, an essential mediator of autophagy. Here, we demonstrate that this interaction involves a BH3 domain within Beclin-1 (residues...
Ribet, David, Louvet-Vallée, Sophie, Harper, Francis, De Parseval, Nathalie, Dewannieux, Marie, Heidmann, Odile, ...
Viruslike particles which displayed a peculiar wheellike appearance that distinguished them from A-, B- or C-type particles had previously been described in the early mouse embryo. The maximum...
Ribet, David, Harper, Francis, Esnault, Cécile, Pierron, Gérard, Heidmann, Thierry
Several families of endogenous retroviruses (ERVs) have been identified in the mouse genome, in several instances by in silico searches, but for many of them it remains to be determined whether there...
Ribet, David, Harper, Francis, Dupressoir, Anne, Dewannieux, Marie, Pierron, Gérard, Heidmann, Thierry
Mammalian genomes contain a high load of mobile elements among which long terminal repeat (LTR)- retrotransposons may represent up to 10% of the genomic DNA. The murine intracisternal A-type particle...