Fuqu Yu, Josephine N. Harada, Helen J. Brown, Hongyu Deng, Moon Jung Song, Ting-Ting Wu, ...
The herpesvirus life cycle has two distinct phases: latency and lytic replication. The balance between these two phases is critical for viral pathogenesis. It is believed that cellular signals...
Therapeutic intervention based on protein prenylation and associated modifications (2006)
Gelb, Michael H., Brunsveld, Lucas, Hrycyna, Christine A., Michaelis, Susan, Tamanoi, Fuyuhiko, Van Voorhis, Wesley C., ...
A Genetic Approach to Define the Importance of Rheb in Tuberous Sclerosis (1998)
We have accomplished the generation of mice with an altered Rheb1 gene expression. In addition, we have also successfully generated an antibody which is highly specific for mouse Rheb2. Investigation...
Suzuki, Nobutaka, Del Villar, Keith, Tamanoi, Fuyuhiko
Farnesyltransferase inhibitors (FTIs) exhibit the remarkable ability to inhibit transformed phenotypes of a variety of human cancer cell lines and to block the growth of cancer cells in a number of...
Suzuki, Nobutaka, Urano, Jun, Tamanoi, Fuyuhiko
Farnesyltransferase inhibitors (FTIs) represent a new class of anticancer drugs that show promise in blocking the growth of tumors. Here, we report that FTIs are capable of inducing apoptosis of...
Robinson, Nicole G. G., Guo, Lea, Imai, Jun, Toh-e, Akio, Matsui, Yasushi, Tamanoi, Fuyuhiko
The Rho3 protein plays a critical role in the budding yeast Saccharomyces cerevisiae by directing proper cell growth. Rho3 appears to influence cell growth by regulating polarized secretion and the...
Kato-Stankiewicz, Juran, Hakimi, Irina, Zhi, Gang, Zhang, Jie, Serebriiskii, Ilya, Guo, Lea, ...
The interaction of activated Ras with Raf initiates signaling cascades that contribute to a significant percentage of human tumors, suggesting that agents that specifically disrupt this interaction...
Fighting cancer by disrupting C-terminal methylation of signaling proteins
Clarke, Steven, Tamanoi, Fuyuhiko
Protein methylation at the C-terminus of mammalian isoprenylated proteins has been implicated in membrane attachment, protein-protein interactions, and protein stability. A new paper describes...
Uracil incorporation into nascent DNA of thymine-requiring mutant of Bacillus subtilis 168
Tamanoi, Fuyuhiko, Okazak, Tuneko
A thymine-requiring mutant of Bacillus subtilis strain 168 accumulates short DNA chains after brief pulses with [3H]thymidine. Reversion of the thy mutation to thy+ abolishes the accumulation of...
A tagging-via-substrate technology for detection and proteomics of farnesylated proteins
Kho, Yoonjung, Kim, Sung Chan, Jiang, Chen, Barma, Deb, Kwon, Sung Won, Cheng, Jinke, ...
A recently developed proteomics strategy, designated tagging-via-substrate (TAS) approach, is described for the detection and proteomic analysis of farnesylated proteins. TAS technology involves...
Suzuki, Nobutaka, Del Villar, Keith, Tamanoi, Fuyuhiko
Farnesyltransferase inhibitors (FTIs) exhibit the remarkable ability to inhibit transformed phenotypes of a variety of human cancer cell lines and to block the growth of cancer cells in a number of...
Suzuki, Nobutaka, Urano, Jun, Tamanoi, Fuyuhiko
Farnesyltransferase inhibitors (FTIs) represent a new class of anticancer drugs that show promise in blocking the growth of tumors. Here, we report that FTIs are capable of inducing apoptosis of...
Robinson, Nicole G. G., Guo, Lea, Imai, Jun, Toh-e, Akio, Matsui, Yasushi, Tamanoi, Fuyuhiko
The Rho3 protein plays a critical role in the budding yeast Saccharomyces cerevisiae by directing proper cell growth. Rho3 appears to influence cell growth by regulating polarized secretion and the...
Kato-Stankiewicz, Juran, Hakimi, Irina, Zhi, Gang, Zhang, Jie, Serebriiskii, Ilya, Guo, Lea, ...
The interaction of activated Ras with Raf initiates signaling cascades that contribute to a significant percentage of human tumors, suggesting that agents that specifically disrupt this interaction...
Fighting cancer by disrupting C-terminal methylation of signaling proteins
Clarke, Steven, Tamanoi, Fuyuhiko
Protein methylation at the C-terminus of mammalian isoprenylated proteins has been implicated in membrane attachment, protein-protein interactions, and protein stability. A new paper describes...
Uracil incorporation into nascent DNA of thymine-requiring mutant of Bacillus subtilis 168
Tamanoi, Fuyuhiko, Okazak, Tuneko
A thymine-requiring mutant of Bacillus subtilis strain 168 accumulates short DNA chains after brief pulses with [3H]thymidine. Reversion of the thy mutation to thy+ abolishes the accumulation of...
A tagging-via-substrate technology for detection and proteomics of farnesylated proteins
Kho, Yoonjung, Kim, Sung Chan, Jiang, Chen, Barma, Deb, Kwon, Sung Won, Cheng, Jinke, ...
A recently developed proteomics strategy, designated tagging-via-substrate (TAS) approach, is described for the detection and proteomic analysis of farnesylated proteins. TAS technology involves...
Systematic Identification of Cellular Signals Reactivating Kaposi Sarcoma–Associated Herpesvirus
Yu, Fuqu, Harada, Josephine N, Brown, Helen J, Deng, Hongyu, Song, Moon Jung, Wu, Ting-Ting, ...
The herpesvirus life cycle has two distinct phases: latency and lytic replication. The balance between these two phases is critical for viral pathogenesis. It is believed that cellular signals...
Matsuo, Tomohiko, Otsubo, Yoko, Urano, Jun, Tamanoi, Fuyuhiko, Yamamoto, Masayuki
Fission yeast has two TOR (target of rapamycin) kinases, namely Tor1 and Tor2. Tor1 is required for survival under stressed conditions, proper G1 arrest, and sexual development. In contrast, Tor2 is...
Urano, Jun, Sato, Tatsuhiro, Matsuo, Tomohiko, Otsubo, Yoko, Yamamoto, Masayuki, Tamanoi, Fuyuhiko
Rheb is a unique member of the Ras superfamily GTP-binding proteins. We as well as others previously have shown that Rheb is a critical component of the TSC/TOR signaling pathway. In fission yeast,...