Gaillard, Helene, Fitzgerald, Daniel J., Smith, Corey Lewis, Peterson, Craig L., Richmond, Timothy J., Thoma, Fritz
Nucleosomes inhibit DNA repair in vitro, suggesting that chromatin remodeling activities might be required for efficient repair in vivo. To investigate how structural and dynamic properties of...
Lopez, Sébastien, Livingstone-Zatchej, Magda, Jourdain, Sabine, Thoma, Fritz, Sentenac, André, Marsolier, Marie-Claude
Transcription of yeast class III genes involves the formation of a transcription initiation complex that comprises RNA polymerase III (Pol III) and the general transcription factors TFIIIB and...
Suter, Bernhard, Wellinger, Ralf-Erik, Thoma, Fritz
DNA damage formation and repair are tightly linked to protein–DNA interactions in chromatin. We have used minichromosomes in yeast as chromatin substrates in vivo to investigate how nucleotide...
Poly(dA·dT) sequences exist as rigid DNA structures in nucleosome-free yeast promoters in vivo
Suter, Bernhard, Schnappauf, Georg, Thoma, Fritz
Poly(dA·dT) sequences (T-tracts) are abundant genomic DNA elements with unusual properties in vitro and an established role in transcriptional regulation of yeast genes. In vitro T-tracts are...
Valerius, Oliver, Brendel, Cornelia, Wagner, Claudia, Krappmann, Sven, Thoma, Fritz, Braus, Gerhard H.
ARO4 and HIS7 are two tandemly orientated genes of Saccharomyces cerevisiae that are transcribed into the same direction. The ARO4 terminator and the HIS7 promoter regions are sensitive to...
Aboussekhra, Abdelilah, Thoma, Fritz
A high-resolution primer extension technique was used to study the relationships between repair, transcription, and mutagenesis in RNA polymerase III transcribed genes in Saccharomyces cerevisiae....
Kinetochores Prevent Repair of UV Damage in Saccharomyces cerevisiae Centromeres
Capiaghi, Christoph, Ho, The Vinh, Thoma, Fritz
Centromeres form specialized chromatin structures termed kinetochores which are required for accurate segregation of chromosomes. DNA lesions might disrupt protein-DNA interactions, thereby...
UV photofootprinting and repair of pyrimidine dimers by photolyase was used to investigate chromatin structure, protein-DNA interactions, and DNA repair in the spacer and promoter of Saccharomyces...
Lopez, Sébastien, Livingstone-Zatchej, Magda, Jourdain, Sabine, Thoma, Fritz, Sentenac, André, Marsolier, Marie-Claude
Transcription of yeast class III genes involves the formation of a transcription initiation complex that comprises RNA polymerase III (Pol III) and the general transcription factors TFIIIB and...
Suter, Bernhard, Wellinger, Ralf-Erik, Thoma, Fritz
DNA damage formation and repair are tightly linked to protein–DNA interactions in chromatin. We have used minichromosomes in yeast as chromatin substrates in vivo to investigate how nucleotide...
Poly(dA·dT) sequences exist as rigid DNA structures in nucleosome-free yeast promoters in vivo
Suter, Bernhard, Schnappauf, Georg, Thoma, Fritz
Poly(dA·dT) sequences (T-tracts) are abundant genomic DNA elements with unusual properties in vitro and an established role in transcriptional regulation of yeast genes. In vitro T-tracts are...
Valerius, Oliver, Brendel, Cornelia, Wagner, Claudia, Krappmann, Sven, Thoma, Fritz, Braus, Gerhard H.
ARO4 and HIS7 are two tandemly orientated genes of Saccharomyces cerevisiae that are transcribed into the same direction. The ARO4 terminator and the HIS7 promoter regions are sensitive to...
Aboussekhra, Abdelilah, Thoma, Fritz
A high-resolution primer extension technique was used to study the relationships between repair, transcription, and mutagenesis in RNA polymerase III transcribed genes in Saccharomyces cerevisiae....
Kinetochores Prevent Repair of UV Damage in Saccharomyces cerevisiae Centromeres
Capiaghi, Christoph, Ho, The Vinh, Thoma, Fritz
Centromeres form specialized chromatin structures termed kinetochores which are required for accurate segregation of chromosomes. DNA lesions might disrupt protein-DNA interactions, thereby...
UV photofootprinting and repair of pyrimidine dimers by photolyase was used to investigate chromatin structure, protein-DNA interactions, and DNA repair in the spacer and promoter of Saccharomyces...
Rapid accessibility of nucleosomal DNA in yeast on a second time scale
Bucceri, Andrea, Kapitza, Kristin, Thoma, Fritz
Packaging DNA in nucleosomes and higher-order chromatin structures restricts its accessibility and constitutes a barrier for all DNA transactions including gene regulation and DNA repair. How and how...
Contribution of the Serine 129 of Histone H2A to Chromatin Structure▿
Fink, Michel, Imholz, Daniela, Thoma, Fritz
Phosphorylation of a yeast histone H2A at C-terminal serine 129 has a central role in double-strand break repair. Mimicking H2A phosphorylation by replacement of serine 129 with glutamic acid...