Fritz H. Bach

Heme oxygenase-1 mediates the anti-inflammatory effects of acute alcohol on IL-10 induction involving p38 MAPK activation in monocytes (2006)

Drechsler, Yvonne, Dolganiuc, Angela, Norkina, Oxana, Romics, Laszlo, Li, Weibo, Kodys, Karen, ...

Inflammation and immunoregulatory cytokines play a central role in alcohol-induced liver damage. We previously reported that acute alcohol treatment augments IL-10 and inhibits TNF-alpha production...

Studies of the mixed lymphocyte reaction by the virus plaque assay (1975)

Kano, Shogo, Bloom, Barry R., Shreffler, Donald C., Schendel, Dolores, Bach, Fritz H.

The virus plaque assay has been developed as a tool for enumerating activated lymphocytes. In previous studies using mitogens it was found that the assay detects activated T- but not activated...

CELL KINETIC STUDIES IN MIXED LEUKOCYTE CULTURES: AN in vitro MODEL OF HOMOGRAFT REACTIVITY*

Bach, Fritz H., Bock, Harvey, Graupner, Kenneth, Day, Elizabeth, Klostermann, Heidi

The recognition phase of homograft immunity can be studied in vitro in the mixed leukocyte culture reaction. In this reaction, at the end of seven days, up to 30 per cent of the lymphocytes in...

CELL KINETIC STUDIES IN MIXED LEUKOCYTE CULTURES: AN in vitro MODEL OF HOMOGRAFT REACTIVITY*

Bach, Fritz H., Bock, Harvey, Graupner, Kenneth, Day, Elizabeth, Klostermann, Heidi

The recognition phase of homograft immunity can be studied in vitro in the mixed leukocyte culture reaction. In this reaction, at the end of seven days, up to 30 per cent of the lymphocytes in...

Hypoxia-inducible factor 1α stabilization by carbon monoxide results in cytoprotective preconditioning

Chin, Beek Y., Jiang, Ge, Wegiel, Barbara, Wang, Hong J., MacDonald, Theresa, Zhang, Xu Chen, ...

The most salient feature of carbon monoxide (CO)-mediated cytoprotection is the suppression of inflammation and cell death. One of the important cellular targets of CO is the macrophage (mφ). Many...

Carbon Monoxide Protects against Liver Failure through Nitric Oxide–induced Heme Oxygenase 1

Zuckerbraun, Brian S., Billiar, Timothy R., Otterbein, Sherrie L., Kim, Peter K.M., Liu, Fang, Choi, Augustine M.K., ...

Carbon monoxide (CO) and nitric oxide (NO) each have mechanistically unique roles in various inflammatory disorders. Although it is known that CO can induce production of NO and that NO can induce...

PHENOTYPIC EXPRESSIONS OF THE MAJOR HISTOCOMPATIBILITY LOCUS IN MAN (HL-A): LEUKOCYTE ANTIGENS AND MIXED LEUKOCYTE CULTURE REACTIVITY

Amos, D. Bernard, Bach, Fritz H.

The evidence is reviewed that a single genetic system, the major histocompatibility locus in man, HL-A, determines most of the antigens measured by presently available leukocyte isoantisera, and also...

QUANTITATIVE ASSAY OF ANTIGENIC DISPARITY AT HL-A—THE MAJOR HISTOCOMPATIBILITY LOCUS IN MAN

Albertini, Richard J., Bach, Fritz H.

We have extended the method of one-way stimulation in mixed leukocyte culture tests as previously described to quantitate different degrees of stimulation. To demonstrate that the amount of...

RESPONSIVENESS OF GERMFREE MICE IN MIXED LEUKOCYTE CULTURE : REEXAMINING THE NATURE OF THE RESPONDING UNIT

Widmer, Michael B., Sondel, Paul M., Bach, Fritz H.

Conventional (cv) and germfree (gf) mice are able to give a good proliferative response to allogeneic cells in the mixed leukocyte culture (MLC) test, while the response to xenogeneic stimulating...

CELL-MEDIATED LYMPHOLYSIS : IMPORTANCE OF SEROLOGICALLY DEFINEDH-2 REGIONS

Alter, Barbara J., Schendel, Dolores J., Bach, Marilyn L., Bach, Fritz H., Klein, Jan, Stimpfling, Jack H.

The cell-mediated lympholytic capability of mouse spleen cells stimulated in mixed lymphocyte culture is related to the major histocompatibility complex genotype on target lymphocytes. The strain...

SEROLOGICALLY DEFINED AND LYMPHOCYTE-DEFINED COMPONENTS OF THE MAJOR HISTOCOMPATIBILITY COMPLEX IN THE MOUSE

Bach, Fritz H., Widmer, Michael B., Bach, Marilyn L., Klein, Jan

The mixed leukocyte culture (MLC) test is an in vitro model of the recognition phase of the homograft response. For the most part, activation in MLC is dependent on differences of the major...

ROLE OF H-2 LYMPHOCYTE-DEFINED AND SEROLOGICALLY-DEFINED COMPONENTS IN THE GENERATION OF CYTOTOXIC LYMPHOCYTES

Alter, Barbara J., Bach, Fritz H.

The cell-mediated lympholytic capability of mouse spleen cells stimulated in mixed lymphocyte culture is determined by lymphocyte-defined (LD) and serologically-defined (SD) antigenic differences...

GENETIC CONTROL OF CELL-MEDIATED LYMPHOLYSIS IN MOUSE

Schendel, Dolores J., Bach, Fritz H.

H-2 congenic mouse strains were tested in vitro to investigate the genetic control of cell-mediated lympholysis (CML). Combinations were selected such that differences in various segments of H-2...

Carbon Monoxide Generated by Heme Oxygenase 1 Suppresses Endothelial Cell Apoptosis

Brouard, Sophie, Otterbein, Leo E., Anrather, Josef, Tobiasch, Edda, Bach, Fritz H., Choi, Augustine M.K., ...

Heme oxygenase 1 (HO-1) inhibits apoptosis by regulating cellular prooxidant iron. We now show that there is an additional mechanism by which HO-1 inhibits apoptosis, namely by generating the gaseous...

A20 Inhibits Cytokine-Induced Apoptosis and Nuclear Factor κB–Dependent Gene Activation in Islets

Grey, Shane T., Arvelo, Maria B., Hasenkamp, Wendy, Bach, Fritz H., Ferran, Christiane

Insulin-dependent diabetes mellitus (IDDM) is an autoimmune disease resulting from apoptotic destruction of β cells in the islets of Langerhans. Low expression of antioxidants and a predilection to...

Loss of ATP Diphosphohydrolase Activity with Endothelial Cell Activation

Robson, Simon C., Kaczmarek, Elzbieta, Siegel, Jonathan B., Candinas, Daniel, Koziak, Katarzyna, Millan, Maria, ...

Quiescent endothelial cells (EC) regulate blood flow and prevent intravascular thrombosis. This latter effect is mediated in a number of ways, including expression by EC of thrombomodulin and heparan...