The "Act to Amend the Several Acts Respecting Copyrights" (1831) created copyright protection in musical compositions. George P. Reed sued Samuel Carusi in the U.S. Circuit Court for the District of...
Activation of the hedgehog pathway in advanced prostate cancer (2004)
Sheng, Tao, Li, Chengxin, Zhang, Xiaoli, Chi, Sumin, He, Nonggao, Chen, Kai, ...
Abstract Background The hedgehog pathway plays a critical role in the development of prostate. However, the role of the hedgehog pathway in prostate cancer is not clear. Prostate cancer is the second...
Identification of Functions of Neurofibromin Distinct from the RASGAP Domain (1998)
We proposed to study new functions of neurofibromin in the model organism, the budding yeast, Saccharornyces cerevisiae. The design of our study is mainly to generate dominant negative mutants of...
Identification of Functions of Neurofibromin Distinct From the RasGAP Domain (1998)
McCormick, Frank, Ding, Vivianne, Toczyski, David, Ananthnarayan, Suchitra
We proposed to study new functions of neurofibromin in the model organism, the budding yeast, Saccharomyces cerevisiae. The design of our study is mainly to generate dominant negative mutants of...
A role of PDGFRα in basal cell carcinoma proliferation
Xie, Jingwu, Aszterbaum, Michelle, Zhang, Xiaoli, Bonifas, Jeannette M., Zachary, Christopher, Epstein, Ervin, ...
Activation of the hedgehog pathway, through the loss of patched (PTC) or the activation of smoothened (SMO), occurs frequently in basal cell carcinoma (BCC), the most common human cancer. However,...
SOCS-3 is frequently silenced by hypermethylation and suppresses cell growth in human lung cancer
He, Biao, You, Liang, Uematsu, Kazutsugu, Zang, Keling, Xu, Zhidong, Lee, Amie Y., ...
Lung cancer is the leading cause of cancer death in the world, but the molecular mechanisms for its development have not been well characterized. The suppressors of cytokine signaling (SOCS) are...
Timmerman, Luika A., Grego-Bessa, Joaquín, Raya, Angel, Bertrán, Esther, Pérez-Pomares, José María, Díez, Juan, ...
Epithelial-to-mesenchymal transition (EMT) is fundamental to both embryogenesis and tumor metastasis. The Notch intercellular signaling pathway regulates cell fate determination throughout metazoan...
Rodriguez-Viciana, Pablo, Sabatier, Celine, McCormick, Frank
Ras family GTPases (RFGs) regulate signaling pathways that control multiple biological processes. How signaling specificity among the closely related family members is achieved is poorly understood....
Role for PP2A in ARF signaling to p53
Moule, Madeleine G., Collins, Crista H., McCormick, Frank, Fried, Mike
Activation of the ARF–p53 tumor suppressor pathway is one of the cell's major defense mechanisms against cancer induced by oncogenes. The ARF–p53 pathway is dysfunctional in a high proportion of...
Activation of the hedgehog pathway in advanced prostate cancer
Sheng, Tao, Li, Chengxin, Zhang, Xiaoli, Chi, Sumin, He, Nonggao, Chen, Kai, ...
Adenoviral proteins mimic nutrient/growth signals to activate the mTOR pathway for viral replication
O'Shea, Clodagh, Klupsch, Kristina, Choi, Serah, Bagus, Bridget, Soria, Conrado, Shen, Jerry, ...
Like tumor cells, DNA viruses have had to evolve mechanisms that uncouple cellular replication from the many intra- and extracellular factors that normally control it. Here we show that adenovirus...
Kinetics of polyamine synthesis and turnover in mouse fibroblasts
Kinetics of polyamine synthesis and degradation were studied in mouse fibroblasts growing in suspension culture. The approach was to prelabel cells with radioactive polyamines and to observe the rate...
A Monoclonal Antibody against Wnt-1 Induces Apoptosis in Human Cancer Cells1
He, Biao, You, Liang, Uematsu, Kazutsugu, Xu, Zhidong, Lee, Amie Y, Matsangou, Maria, ...
Aberrant activation of the Wingless-type (Wnt)/β-catenin signaling pathway is associated with a variety of human cancers. Little is known regarding the role that Wnt ligands play in human...
A role of PDGFRα in basal cell carcinoma proliferation
Xie, Jingwu, Aszterbaum, Michelle, Zhang, Xiaoli, Bonifas, Jeannette M., Zachary, Christopher, Epstein, Ervin, ...
Activation of the hedgehog pathway, through the loss of patched (PTC) or the activation of smoothened (SMO), occurs frequently in basal cell carcinoma (BCC), the most common human cancer. However,...
SOCS-3 is frequently silenced by hypermethylation and suppresses cell growth in human lung cancer
He, Biao, You, Liang, Uematsu, Kazutsugu, Zang, Keling, Xu, Zhidong, Lee, Amie Y., ...
Lung cancer is the leading cause of cancer death in the world, but the molecular mechanisms for its development have not been well characterized. The suppressors of cytokine signaling (SOCS) are...
Timmerman, Luika A., Grego-Bessa, Joaquín, Raya, Angel, Bertrán, Esther, Pérez-Pomares, José María, Díez, Juan, ...
Epithelial-to-mesenchymal transition (EMT) is fundamental to both embryogenesis and tumor metastasis. The Notch intercellular signaling pathway regulates cell fate determination throughout metazoan...
Rodriguez-Viciana, Pablo, Sabatier, Celine, McCormick, Frank
Ras family GTPases (RFGs) regulate signaling pathways that control multiple biological processes. How signaling specificity among the closely related family members is achieved is poorly understood....
Role for PP2A in ARF signaling to p53
Moule, Madeleine G., Collins, Crista H., McCormick, Frank, Fried, Mike
Activation of the ARF–p53 tumor suppressor pathway is one of the cell's major defense mechanisms against cancer induced by oncogenes. The ARF–p53 pathway is dysfunctional in a high proportion of...
Activation of the hedgehog pathway in advanced prostate cancer
Sheng, Tao, Li, Chengxin, Zhang, Xiaoli, Chi, Sumin, He, Nonggao, Chen, Kai, ...
Adenoviral proteins mimic nutrient/growth signals to activate the mTOR pathway for viral replication
O'Shea, Clodagh, Klupsch, Kristina, Choi, Serah, Bagus, Bridget, Soria, Conrado, Shen, Jerry, ...
Like tumor cells, DNA viruses have had to evolve mechanisms that uncouple cellular replication from the many intra- and extracellular factors that normally control it. Here we show that adenovirus...
Kinetics of polyamine synthesis and turnover in mouse fibroblasts
Kinetics of polyamine synthesis and degradation were studied in mouse fibroblasts growing in suspension culture. The approach was to prelabel cells with radioactive polyamines and to observe the rate...
A Monoclonal Antibody against Wnt-1 Induces Apoptosis in Human Cancer Cells1
He, Biao, You, Liang, Uematsu, Kazutsugu, Xu, Zhidong, Lee, Amie Y, Matsangou, Maria, ...
Aberrant activation of the Wingless-type (Wnt)/β-catenin signaling pathway is associated with a variety of human cancers. Little is known regarding the role that Wnt ligands play in human...
A Critical Role for FBXW8 and MAPK in Cyclin D1 Degradation and Cancer Cell Proliferation
Okabe, Hiroshi, Lee, Sang-Hyun, Phuchareon, Janyaporn, Albertson, Donna G., McCormick, Frank, Tetsu, Osamu
Cyclin D1 regulates G1 progression. Its transcriptional regulation is well understood. However, the mechanism underlying cyclin D1 ubiquitination and its subsequent degradation is not yet clear. We...
Lee, Sang Hyun, McCormick, Frank
p97 (also referred to as DAP5, NAT1 or eIF4G2) has been proposed to act as a repressor of protein synthesis. However, we found that p97 is abundantly expressed in proliferating cells and p97 is...
Mutation Analysis of BRAF, MEK1 and MEK2 in 15 Ovarian Cancer Cell Lines: Implications for Therapy
Estep, Anne L., Palmer, Chana, McCormick, Frank, Rauen, Katherine A.
Critical Role for Arginine Methylation in Adenovirus-Infected Cells▿
Iacovides, Demetris C., O'Shea, Clodagh C., Oses-Prieto, Juan, Burlingame, Alma, McCormick, Frank
During the late stages of adenovirus infection, the 100K protein (100K) inhibits the translation of cellular messages in the cytoplasm and regulates hexon trimerization and assembly in the nucleus....
DNA methylation analysis by digital bisulfite genomic sequencing and digital MethyLight
Weisenberger, Daniel J., Trinh, Binh N., Campan, Mihaela, Sharma, Shikhar, Long, Tiffany I., Ananthnarayan, Suchitra, ...
Alterations in cytosine-5 DNA methylation are frequently observed in most types of human cancer. Although assays utilizing PCR amplification of bisulfite-converted DNA are widely employed to analyze...